Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Francesco Schianchi"'
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Akademický článek
Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR–v-ATPase axis
Autor: Shujin Wang, Francesco Schianchi, Dietbert Neumann, Li-Yen Wong, Aomin Sun, Frans A. van Nieuwenhoven, Maurice P. Zeegers, Agnieszka Strzelecka, Umare Col, Jan F.C. Glatz, Miranda Nabben, Joost J.F.P. Luiken
Publikováno v: Molecular Metabolism, Vol 53, Iss , Pp 101293- (2021)
Objective: The diabetic heart is characterized by extensive lipid accumulation which often leads to cardiac contractile dysfunction. The underlying mechanism involves a pivotal role for vacuolar-type H+-ATPase (v-ATPase, functioning as endosomal/lyso
Externí odkaz: https://doaj.org/article/b07f1d46600c4e0f93aa0b55a7f9c66d
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2
Ketone Body Exposure of Cardiomyocytes Impairs Insulin Sensitivity and Contractile Function through Vacuolar-Type H+-ATPase Disassembly—Rescue by Specific Amino Acid Supplementation
Autor: Shujin Wang, Dietbert Neumann, B. Daan Westenbrink, Francesco Schianchi, Li-Yen Wong, Aomin Sun, Agnieszka Strzelecka, Jan F. C. Glatz, Joost J. F. P. Luiken, Miranda Nabben
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 12909
International Journal of Molecular Sciences, 23(21):12909. MDPI AG
International journal of molecular sciences, 23(21):12909. Multidisciplinary Digital Publishing Institute (MDPI)
The heart is metabolically flexible. Under physiological conditions, it mainly uses lipids and glucose as energy substrates. In uncontrolled diabetes, the heart switches towards predominant lipid utilization, which over time is detrimental to cardiac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271271f426d3b4ebb25cd7ea28570770
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4
Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR-v-ATPase axis
Autor: Francesco Schianchi, Frans A. van Nieuwenhoven, Dietbert Neumann, Jan F. C. Glatz, Li-Yen Wong, Aomin Sun, Shujin Wang, Agnieszka Strzelecka, Umare Col, Maurice P. Zeegers, Miranda Nabben, Joost J. F. P. Luiken
Publikováno v: Molecular Metabolism, 53:101293. Elsevier
Molecular Metabolism, Vol 53, Iss, Pp 101293-(2021)
Molecular Metabolism
Objective The diabetic heart is characterized by extensive lipid accumulation which often leads to cardiac contractile dysfunction. The underlying mechanism involves a pivotal role for vacuolar-type H+-ATPase (v-ATPase, functioning as endosomal/lysos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1704faca1e7512f438960dfe1ededd
https://cris.maastrichtuniversity.nl/en/publications/7e6b5f37-3c7d-4570-be69-f045bcc08baf
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5
Metabolic Interventions to Prevent Hypertrophy-Induced Alterations in Contractile Properties In Vitro
Autor: Jan F. C. Glatz, Ilvy M. E. Geraets, Dimitrios Kapsokalyvas, Gudrun Antoons, Agnieszka Strzelecka, Myrthe M. A. Willemars, Will A. Coumans, Miranda Nabben, Francesco Schianchi, Patrick Schönleitner, Joost J. F. P. Luiken
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3620, p 3620 (2021)
International journal of molecular sciences, 22(7):3620. Multidisciplinary Digital Publishing Institute (MDPI)
(1) Background: The exact mechanism(s) underlying pathological changes in a heart in transition to hypertrophy and failure are not yet fully understood. However, alterations in cardiac energy metabolism seem to be an important contributor. We charact
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691f0aa7464a95e5ee3025501490f183
http://europepmc.org/articles/PMC8037191
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6
Putative Role of Protein Palmitoylation in Cardiac Lipid-Induced Insulin Resistance
Autor: Artur Navarro Gascon, Francesco Schianchi, Jan F. C. Glatz, Miranda Nabben, Dietbert Neumann, Joost J. F. P. Luiken
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 9438, p 9438 (2020)
In the heart, inhibition of the insulin cascade following lipid overload is strongly associated with contractile dysfunction. The translocation of fatty acid transporter CD36 (SR-B2) from intracellular stores to the cell surface is a hallmark event i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044d7f93518df5675ecccf9183bb68dc
https://doi.org/10.3390/ijms21249438
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