Zobrazeno 1 - 10
of 340
pro vyhledávání: '"Francesco Peri"'
Autor:
Martina Arici, Shih-Che Hsu, Mara Ferrandi, Paolo Barassi, Carlotta Ronchi, Eleonora Torre, Andrea Luraghi, Gwo-Jyh Chang, Patrizia Ferrari, Giuseppe Bianchi, Francesco Peri, Antonio Zaza, Marcella Rocchetti
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background The sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA2a) depression substantially contributes to diastolic dysfunction in heart failure (HF), suggesting that SERCA2a stimulation may be a mechanism-based HF therapy. Istaroxime is a dr
Externí odkaz:
https://doaj.org/article/782d6a7de41e442dbf9d2b9799220397
Autor:
Alessia D’Aloia, Valentina Pastori, Stefania Blasa, Gloria Campioni, Francesco Peri, Elena Sacco, Michela Ceriani, Marzia Lecchi, Barbara Costa
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract Modeling human neuronal properties in physiological and pathological conditions is essential to identify novel potential drugs and to explore pathological mechanisms of neurological diseases. For this purpose, we generated a three-dimensiona
Externí odkaz:
https://doaj.org/article/b33ea0b97fea4ce4a03ef227549ea2de
Autor:
Deebika Balu, Ana C. Valencia-Olvera, Austin Nguyen, Mehul Patnam, Jason York, Francesco Peri, Frank Neumann, Mary Jo LaDu, Leon M. Tai
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2023)
Abstract Background APOE genotype is the greatest genetic risk factor for sporadic Alzheimer’s disease (AD). APOE4 increases AD risk up to 12-fold compared to APOE3, an effect that is greater in females. Evidence suggests that one-way APOE could mo
Externí odkaz:
https://doaj.org/article/de76612f85be4698b212d45dc76b6695
Autor:
Alessio Romerio, Ana Rita Franco, Melanie Shadrick, Mohammed Monsoor Shaik, Valentina Artusa, Alice Italia, Federico Lami, Alexei V. Demchenko, Francesco Peri
Publikováno v:
ACS Omega, Vol 8, Iss 39, Pp 36412-36417 (2023)
Externí odkaz:
https://doaj.org/article/9ce4d6ac3c704d55ac40b629ad056cae
Autor:
Alessio Romerio, Francesco Peri
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
We developed synthetic glycophospholipids based on a glucosamine core (FP compounds) with potent and selective activity in stimulating Toll-Like Receptor 4 (TLR4) as agonists. These compounds have activity and toxicity profiles similar to the clinica
Externí odkaz:
https://doaj.org/article/a55b07ec08cd4570ab8f92c944236b6b
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 999 (2023)
Emerging pharmacological strategies that target major virulence factors of antibiotic-resistant Mycobacterium tuberculosis (Mtb) are presented and discussed. This review is divided into three parts corresponding to structures and functions important
Externí odkaz:
https://doaj.org/article/2af06f43941a4d5993c8fa578faecd83
Autor:
Valentina Artusa, Carlotta Ciaramelli, Alessia D’Aloia, Fabio Alessandro Facchini, Nicole Gotri, Antonino Bruno, Barbara Costa, Alessandro Palmioli, Cristina Airoldi, Francesco Peri
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The anti-inflammatory activity of coffee extracts is widely recognized and supported by experimental evidence, in both in vitro and in vivo settings, mainly murine models. Here, we investigated the immunomodulatory properties of coffee extracts from
Externí odkaz:
https://doaj.org/article/a9bfa59ed02e441980d4d204551ec1c6
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4997 (2023)
Cancer stem cells (CSCs) have drawn much attention as important tumour-initiating cells that may also be crucial for recurrence after chemotherapy. Although the activity of CSCs in various forms of cancer is complex and yet to be fully elucidated, op
Externí odkaz:
https://doaj.org/article/a923cad30a074480b6bac0a559aad2ae
Autor:
Diletta Ami, Ana Rita Franco, Valentina Artusa, Paolo Mereghetti, Francesco Peri, Antonino Natalello
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13447 (2022)
Macrophages are among the first immune cells involved in the initiation of the inflammatory response to protect the host from pathogens. THP-1 derived macrophages (TDM) are used as a model to study the pro-inflammatory effects of lipopolysaccharide (
Externí odkaz:
https://doaj.org/article/0ba58c5d39f1417395797d342e438f4b
Autor:
Charys Palmer, Fabio A Facchini, Richard PO Jones, Frank Neumann, Francesco Peri, Grisha Pirianov
Publikováno v:
Innate Immunity, Vol 27 (2021)
TLRs, including TLR4, play a crucial role in inflammatory-based diseases, and TLR4 has been identified as a therapeutic target for pharmacological intervention. In previous studies, we investigated the potential of FP7, a novel synthetic glycolipid a
Externí odkaz:
https://doaj.org/article/0f950b35b5494805819fe542b8e32496