Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Francesco Paonessa"'
Publikováno v:
PPAR Research, Vol 2009 (2009)
The insulin receptor (IR) plays a crucial role in mediating the metabolic and proliferative functions triggered by the peptide hormone insulin. There is considerable evidence that abnormalities in both IR expression and function may account for malig
Externí odkaz:
https://doaj.org/article/fd8008d245c24eb786f93163c8631b54
Autor:
Ioakeim Ampartzidis, Christoforos Efstathiou, Francesco Paonessa, Elliott M Thompson, Tyler Wilson, Conor J McCann, Nicholas DE Greene, Andrew Copp, Frederick J Livesey, Nicola Elvassore, Giovanni Giuseppe Giobbe, Paolo De Coppi, Eirini Maniou, Gabriel L Galea
Publikováno v:
Developmental biology.
Neuroepithelial cells balance tissue growth requirement with the morphogenetic imperative of closing the neural tube. They apically constrict to generate mechanical forces which elevate the neural folds, but are thought to apically dilate during mito
Autor:
Frederick J. Livesey, Delphine Larrieu, Francesco Paonessa, John Hardy, Stephen P. Jackson, Selina Wray, Lewis D. B. Evans, Ravi Solanki
SUMMARYThe neuronal microtubule-associated protein tau (MAPT) is central to the pathogenesis of many dementias, including Alzheimer’s disease. Autosomal dominant mutations inMAPTcause inherited frontotemporal dementia (FTD), but the underlying path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61df6293e256af6f5d5aaf66fc8e636e
https://doi.org/10.1101/328187
https://doi.org/10.1101/328187
Autor:
Francesco, Paonessa, Lewis D, Evans, Ravi, Solanki, Delphine, Larrieu, Selina, Wray, John, Hardy, Stephen P, Jackson, Frederick J, Livesey
Publikováno v:
Cell Reports
Summary The neuronal microtubule-associated protein tau, MAPT, is central to the pathogenesis of many dementias. Autosomal-dominant mutations in MAPT cause inherited frontotemporal dementia (FTD), but the underlying pathogenic mechanisms are unclear.
Autor:
Davide Pozzi, Pietro Baldelli, Jacopo Meldolesi, Enrico Ferrea, Francesco Paonessa, Pellegrino Lippiello, Davide Boido, Flavia Valtorta, Andrea Contestabile, Rosalba D'Alessandro, Gabriele Lignani, Anna Fassio, Fabio Benfenati
Publikováno v:
The EMBO Journal. 32:2994-3007
Intrinsic homeostasis enables neuronal circuits to maintain activity levels within an appropriate range by modulating neuronal voltage-gated conductances, but the signalling pathways involved in this process are largely unknown. We characterized the
Autor:
Federico Pecoraro Bisogni, Helena Scarongella, Stefania Criscuolo, Emanuele Carminati, Fabio Benfenati, Fabrizia Cesca, Luca Maragliano, Francesco Paonessa, Davide Amoroso, Silvio Sacchetti, Giacomo Pruzzo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(1)
Optogenetics provides new ways to activate gene transcription; however, no attempts have been made as yet to modulate mammalian transcription factors. We report the light-mediated regulation of the repressor element 1 (RE1)-silencing transcription fa
Publikováno v:
PPAR Research. 2009:1-8
The insulin receptor (IR) plays a crucial role in mediating the metabolic and proliferative functions triggered by the peptide hormone insulin. There is considerable evidence that abnormalities in both IR expression and function may account for malig
Autor:
Eusebio Chiefari, Daniela Foti, L Palaia, G Brunetti, Elio Gulletta, Arturo Brunetti, Francesco Paonessa, V Costa, Alfredo Fusco
Publikováno v:
Endocrine Related Cancer. 15:325-335
The peroxisome proliferator-activated receptor-gamma (PPARgamma) is a member of the nuclear hormone receptor superfamily. Ligand activation of PPARgamma is associated with differentiation and inhibition of proliferation in the normal and malignant ce
Autor:
Elio Gulletta, Alfredo Fusco, Vanessa Costa, Frank Wu, Giuseppe Brunetti, Francesco Leone, Amy S. Lee, Daniela Foti, Antonio Brunetti, Francesco Paonessa, Eusebio Chiefari, Francesco Luciano
Publikováno v:
Cancer Research. 66:5085-5093
Various studies have shown that the insulin receptor (IR) is increased in most human breast cancers, and both ligand-dependent malignant transformation and increased cell growth occur in cultured breast cells overexpressing the IR. However, although
Autor:
Alfredo Fusco, Arturo Brunetti, Daniela Foti, Guidalberto Manfioletti, Fabrizio Barbetti, Monica Fedele, Rodolfo Iuliano, Leonardo Brunetti, Carlo M. Croce, Antonio Brunetti, Francesco Paonessa, Eusebio Chiefari
Publikováno v:
Nature medicine
11 (2005): 765–773. doi:10.1038/nm1254
info:cnr-pdr/source/autori:Foti D; Chiefari E; Fedele M; Iuliano R; Brunetti L; Paonessa F; Manfioletti G; Barbetti F; Brunetti A; Croce CM; Fusco A; Brunetti A./titolo:Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice./doi:10.1038%2Fnm1254/rivista:Nature medicine (Print)/anno:2005/pagina_da:765/pagina_a:773/intervallo_pagine:765–773/volume:11
11 (2005): 765–773. doi:10.1038/nm1254
info:cnr-pdr/source/autori:Foti D; Chiefari E; Fedele M; Iuliano R; Brunetti L; Paonessa F; Manfioletti G; Barbetti F; Brunetti A; Croce CM; Fusco A; Brunetti A./titolo:Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice./doi:10.1038%2Fnm1254/rivista:Nature medicine (Print)/anno:2005/pagina_da:765/pagina_a:773/intervallo_pagine:765–773/volume:11
Type 2 diabetes mellitus is a widespread disease, affecting millions of people globally. Although genetics and environmental factors seem to have a role, the cause of this metabolic disorder is largely unknown. Here we report a genetic flaw that mark