Výsledky vyhledávání - "Francesco Paoletti"

Akademický článek

Altered Proteolysis in Fibroblasts of Alzheimer Patients with Predictive Implications for Subjects at Risk of Disease

Autor: Alessandra Mocali, Nunzia Della Malva, Claudia Abete, Vito Antonio Mitidieri Costanza, Antonio Bavazzano, Vieri Boddi, Luis Sanchez, Sandra Dessì, Alessandra Pani, Francesco Paoletti

Publikováno v: International Journal of Alzheimer's Disease, Vol 2014 (2014)

There is great interest in developing reliable biomarkers to support antemortem diagnosis of late-onset Alzheimer’s disease (AD). Early prediction and diagnosis of AD might be improved by the detection of a proteolytic dysfunction in extracts from

Externí odkaz: https://doaj.org/article/77be9e70f06048538c52a839523bfa8b

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Akademický článek

Effectiveness of the histone deacetylase inhibitor (S)-2 against LNCaP and PC3 human prostate cancer cells.

Autor: Anna Laurenzana, Manjola Balliu, Cristina Cellai, Maria Novella Romanelli, Francesco Paoletti

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58267 (2013)

Histone deacetylase inhibitors (HDACi) represent a promising class of epigenetic agents with anticancer properties. Here, we report that (S)-2, a novel hydroxamate-based HDACi, shown previously to be effective against acute myeloid leukemia cells, wa

Externí odkaz: https://doaj.org/article/f5c787c6cdfc4745a1ed506b090b2528

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Akademický článek

Cholesterol esterification during differentiation of mouse erythroleukemia (Friend) cells

Autor: Maria Franca Mulas, Antonella Mandas, Claudia Abete, Sandra Dessì, Alessandra Mocali, Francesco Paoletti

Publikováno v: Hematology Reports, Vol 3, Iss 2, Pp e19-e19 (2011)

Cholesterol is an essential constituent of all mammalian cell membranes, and its availability is therefore a prerequisite for cellular growth and other functions. Several lines of evidence are now indicating an association between alterations of chol

Externí odkaz: https://doaj.org/article/bb833918e6df47748d5f8365510af19b

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HDAC1 controls CIP2A transcription in human colorectal cancer cells

Autor: Eugenio Torre, Matteo Lulli, Alessandro M. Vannucchi, Francesco Paoletti, Cristina Cellai, Anna Laurenzana, Manjola Balliu

Publikováno v: Oncotarget

This work describes the effectiveness of HDAC-inhibitor (S)-2 towards colorectal cancer (CRC) HCT116 cells in vitro by inducing cell cycle arrest and apoptosis, and in vivo by contrasting tumour growth in mice xenografts. Among the multifaceted drug-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1941362233140f12a3036dd0181e3d36
http://hdl.handle.net/2158/1041458

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Altered Cholesterol Ester Cycle in Skin Fibroblasts from Patients with Alzheimer's Disease

Autor: Christina D. Orru, Anna Laurenzana, Maria Dolores Cannas, Claudia Mulas, Antonio Mitidieri Costanza, Sandra Dessì, Alessandra Pani, Cristina Cellai, Paolo La Colla, Pier Luigi Cocco, A. Bavazzano, Paolo Putzu, Giacomo Diaz, Francesco Paoletti, Fabrizio Angius, Antonella Mandas, Alessandra Mocali, Claudia Abete

Publikováno v: Journal of Alzheimer's Disease. 18:829-841

Intracellular cholesterol metabolism was reported to modulate amyloid-beta (Abeta) generation in Alzheimer's disease (AD). Results presented herein demonstrated that, like brain cells, cultured skin fibroblasts from AD patients contained more cholest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d797d4e649992bd2965183712f7e0c04
https://doi.org/10.3233/jad-2009-1193

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Inhibition of DNA Methyltransferase Activates Tumor Necrosis Factor α–Induced Monocytic Differentiation in Acute Myeloid Leukemia Cells

Autor: Luca A. Petruccelli, Anna Laurenzana, Francesco Paoletti, Maria E. Figueroa, Albert S. Baldwin, Ari Melnick, Filippa Pettersson, Wilson H. Miller

Publikováno v: Cancer Research. 69:55-64

Transcriptional silencing via promoter methylation of genes important for cell growth and differentiation plays a key role in myeloid leukemogenesis. We find that clinically achievable levels of 5-aza-2′-deoxycytidine (5-AZA-dC), a potent inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd77e125f1ffc8b97206e8a12d164ff
https://doi.org/10.1158/0008-5472.can-08-0245

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Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents

Autor: Anna Laurenzana, Maria Novella Romanelli, Francesco Paoletti, Cristina Cellai, Luca Guandalini, Serena Scapecchi

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:5071-5074

This study concerns the synthesis of new histone deacetylase inhibitors (HDACi) characterized by a 1,4-benzodiazepine ring used as the cap, joined through an amide function or a triple bond as connection units, to a linear alkyl chain bearing the hyd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fd06030c213f955aa978a6d7d84606
https://doi.org/10.1016/j.bmcl.2008.07.119

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Risk factors for upper limb deep vein thrombosis associated with the use of central vein catheter in cancer patients

Autor: Sergio Bertoglio, Walter Ageno, Maurizio Paciaroni, Mario Bazzan, Stefano Mosca, Giancarlo Agnelli, Francesco Paoletti, Antonio Lazzaro, Melina Verso, Pieter Willem Kamphuisen

Publikováno v: Internal and emergency medicine, 3(2), 117-122. Springer-Verlag Italia
Internal and Emergency Medicine, 3, 2, pp. 117-22
Internal and Emergency Medicine, 3, 117-22

Item does not contain fulltext Deep vein thrombosis of upper limb is a common complication of CVC in patients with cancer. In these patients the risk factors for CVC-related thrombosis are not completely defined. The purpose of this study was to iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b48a9c099f860641a3c6ef7afde42f
https://hdl.handle.net/2066/71122

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