Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Francesco Nordio"'
Autor:
Camilo J. Acosta, Francesco Nordio, Eloi Kpamegan, Kelley J. Moss, Pradeep Kumar, Kazuhiro Hirata
Publikováno v:
Microorganisms, Vol 12, Iss 7, p 1492 (2024)
We previously reported the first-in-human assessment of three doses (2, 5, and 10 µg) of purified inactivated Zika virus vaccine (PIZV or TAK-426) in the Phase 1 ZIK-101 study (NCT03343626). Here, we report dose selection based on extended safety an
Externí odkaz:
https://doaj.org/article/c20d6c65247a42cfa07f6a02e7a4e75d
Autor:
Camilo J. Acosta, Francesco Nordio, David A. Boltz, Whitney R. Baldwin, Greg Hather, Eloi Kpamegan
Publikováno v:
Microorganisms, Vol 12, Iss 6, p 1177 (2024)
A traditional phase 3 clinical efficacy study for a Zika vaccine may be unfeasible because of the current low transmission of Zika virus (ZIKV). An alternative clinical development approach to evaluate Zika vaccine efficacy (VE) is therefore required
Externí odkaz:
https://doaj.org/article/9bdd98c738f1404ab622ff8754bcf668
Autor:
Inge LeFevre, Lulu Bravo, Nicolas Folschweiller, Eduardo Lopez Medina, Edson Duarte Moreira, Francesco Nordio, Mayuri Sharma, Leslie M. Tharenos, Vianney Tricou, Veerachai Watanaveeradej, Peter J. Winkle, Shibadas Biswal
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-9 (2023)
Abstract Immunobridging is an important methodology that can be used to extrapolate vaccine efficacy estimates to populations not evaluated in clinical studies, and that has been successfully used in developing many vaccines. Dengue, caused by a mosq
Externí odkaz:
https://doaj.org/article/37a0af7ecf4841298de437faee7ed315
Autor:
Sanjay S. Patel, Peter Winkle, Alice Faccin, Francesco Nordio, Inge LeFevre, Claudia Galindo Tsoukas
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 19, Iss 2 (2023)
Dengue is caused by a mosquito-transmitted flavivirus. The disease is now endemic to many tropical and subtropical regions, manifesting as approximately 96 million symptomatic cases of dengue each year. Clinical trials have shown TAK-003 (Qdenga®),
Externí odkaz:
https://doaj.org/article/50b950bd413f434ea8be3b20f2fe6d42
Autor:
Dario Consonni, Michele Carugno, Sara De Matteis, Francesco Nordio, Giorgia Randi, Martina Bazzano, Neil E Caporaso, Margaret A Tucker, Pier Alberto Bertazzi, Angela C Pesatori, Jay H Lubin, Maria Teresa Landi
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203539 (2018)
OBJECTIVE:Cohort studies in Europe, but not in North-America, showed an association between exposure to outdoor particulate matter with aerodynamic diameter ≤10 μm (PM10) and lung cancer risk. Only a case-control study on lung cancer and PM10 in S
Externí odkaz:
https://doaj.org/article/3244cde9ac534472989d083d291ee95e
Sudden Cardiac Death in Patients With Atrial Fibrillation: Insights From the ENGAGE AF‐TIMI 48 Trial
Autor:
Alon Eisen, Christian T. Ruff, Eugene Braunwald, Francesco Nordio, Ramón Corbalán, Anthony Dalby, Maria Dorobantu, Michele Mercuri, Hans Lanz, Howard Rutman, Stephen D. Wiviott, Elliott M. Antman, Robert P. Giugliano
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 7 (2016)
BackgroundRecent findings suggest that atrial fibrillation is associated with sudden cardiac death (SCD). We examined the incidence, characteristics, and factors associated with SCD in patients with atrial fibrillation. Methods and ResultsSCD was def
Externí odkaz:
https://doaj.org/article/d768011c03c045a78a472f4bb7ba2c31
Autor:
Eri Toda Kato, Robert P. Giugliano, Christian T. Ruff, Yukihiro Koretsune, Takeshi Yamashita, Robert Gabor Kiss, Francesco Nordio, Sabina A. Murphy, Tetsuya Kimura, James Jin, Hans Lanz, Michele Mercuri, Eugene Braunwald, Elliott M. Antman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 5 (2016)
BackgroundElderly patients with atrial fibrillation are at higher risk of both ischemic and bleeding events compared to younger patients. In a prespecified analysis from the ENGAGE AF‐TIMI 48 trial, we evaluate clinical outcomes with edoxaban versu
Externí odkaz:
https://doaj.org/article/0e6d79c903f14037ac0b1e32f6744c1c
Autor:
Haiyan Xu, Christian T. Ruff, Robert P. Giugliano, Sabina A. Murphy, Francesco Nordio, Indravadan Patel, Minggao Shi, Michele Mercuri, Elliott M. Antman, Eugene Braunwald
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 2 (2016)
BackgroundWe studied the concomitant use of single antiplatelet therapy (SAPT) on the efficacy and safety of the anti‐Xa agent edoxaban in patients with atrial fibrillation (AF). Methods and ResultsENGAGE AF‐TIMI 48 was a randomized trial that co
Externí odkaz:
https://doaj.org/article/91ed106b46234d5f981300d4c1a02676
Autor:
Itai Kloog, Francesco Nordio, Antonella Zanobetti, Brent A Coull, Petros Koutrakis, Joel D Schwartz
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88578 (2014)
Many studies report significant associations between PM(2.5) (particulate matter
Externí odkaz:
https://doaj.org/article/db00ce6486a14a53b0d9544a01dbdb82
Autor:
Hyang-Min Byun, Francesco Nordio, Brent A Coull, Letizia Tarantini, Lifang Hou, Matteo Bonzini, Pietro Apostoli, Pier Alberto Bertazzi, Andrea Baccarelli
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39220 (2012)
DNA methylation is an epigenetic mechanism that has been increasingly investigated in observational human studies, particularly on blood leukocyte DNA. Characterizing the degree and determinants of DNA methylation stability can provide critical infor
Externí odkaz:
https://doaj.org/article/386473d1e80b4c23ac09fd4522592f2a