Výsledky vyhledávání - "Francesco Mincione"

Advances in the discovery of novel agents for the treatment of glaucoma

Autor: Claudiu T. Supuran, Francesco Mincione, Alessio Nocentini

Publikováno v: Expert opinion on drug discovery. 16(10)

Glaucoma, a neuropathy characterized by increased intraocular pressure (IOP), is the major cause of blindness worldwide and its treatment aims at reducing IOP.The authors review the design of the main classes of anti-glaucoma agents. Drugs which inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8974da01c7cbfead8e3cead6aa9091f4
https://pubmed.ncbi.nlm.nih.gov/33914670

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Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action

Autor: Claudiu T. Supuran, Francesca Benedini, Francesco Mincione, Alessandro Cecchi, Claudia Temperini, Ilaria Pacileo, Giuseppe Formicola, Andrea Scozzafava, Emanuela Masini, Stefano Biondi

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 21:3216-3221

Several aromatic/heterocyclic sulfonamide scaffolds have been used to synthesize compounds incorporating NO-donating moieties of the nitrate ester type, which have been investigated for the inhibition of five physiologically relevant human carbonic a

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https://doi.org/10.1016/j.bmcl.2011.04.046

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The Development of Topically Acting Carbonic Anhydrase Inhibitors as Antiglaucoma Agents

Autor: Francesco Mincione, Andrea Scozzafava, Claudiu T. Supuran

Publikováno v: Current Topics in Medicinal Chemistry. 7:849-854

Inhibition of carbonic anhydrase (CA, EC 4.2.1.1) isoforms present in the eyes (CA I, II, IV and XII), with sulfonamides such as acetazolamide, methazolamide, ethoxzolamide and dichlorophenamide, is still widely used for the systemic treatment of gla

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https://doi.org/10.2174/156802607780636735

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Carbonic anhydrase inhibitors: Design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma

Autor: Lucia Bacciottini, Angela Casini, Chiara Scrivanti, Daniela Vullo, Francesco Mincione, Michele Starnotti, Claudiu T. Supuran, Andrea Scozzafava, Emanuela Masini

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:3821-3827

A new series of thioureido-substituted sulfonamides were prepared by reacting 4-isothiocyanato- or 4-isothiocyanatoethyl-benzenesulfonamide with amines, hydrazines, or amino acids bearing moieties that can lead to an enhanced hydrosolubility, such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58a8a550b174c0c88a3747d663c4dbc
https://doi.org/10.1016/j.bmcl.2005.06.054

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Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-α-d-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits

Autor: Michele Starnotti, Angela Casini, Claudiu T. Supuran, Francesco Mincione, Jean-Yves Winum, Andrea Scozzafava, Jean-Louis Montero

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:225-229

A series of N-(p-sulfamoylphenyl)-α- d -glycopyranosylamines was prepared by reaction of sulfanilamide with different monosaccharides in the presence of ammonium chloride. The new compounds were investigated for inhibition of the metallo-enzyme carb

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https://doi.org/10.1016/j.bmcl.2003.09.063

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Cyclodextrin Complexes of Sulfonamide Carbonic Anhydrase IOnhibitors As Long‐lasting Topically Acting Antiglaucoma Agents

Autor: Francesco Mincione, Andrea Scozzafava, Angela Casini, Paola Mura, Claudiu T. Supuran, Francesca Maestrelli

Publikováno v: Journal of Pharmaceutical Sciences. 91:2211-2219

Complexes of several 1,3,4-thiadiazole-2-sulfonamide derivatives possessing strong carbonic anhydrase (CA) inhibitory properties with β-cyclodextrin and hydroxypropyl-β-cyclodextrin were obtained and characterized. Although the investigated CA inhi

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https://doi.org/10.1002/jps.10215

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Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties

Autor: Luca Menabuoni, Andrea Scozzafava, Giovanna Mincione, Francesco Mincione, Claudiu T. Supuran

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:575-582

Reaction of diethylenetriamino pentaacetic acid (dtpa) dianhydride with aromatic/heterocyclic sulfonamides possessing a free amino/imino/hydrazino/hydroxy group afforded bis-sulfonamides containing metal-complexing, polyamino-polycarboxylic acid moie

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https://doi.org/10.1016/s0960-894x(00)00722-8

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Carbonic Anhydrase Inhibitors: Perfluoroalkyl/Aryl-Substituted Derivatives of Aromatic/Heterocyclic Sulfonamides as Topical Intraocular Pressure-Lowering Agents with Prolonged Duration of Action

Autor: Claudiu T. Supuran, Fabrizio Briganti, Francesco Mincione, Luca Menabuoni, Giovanna Mincione, Andrea Scozzafava

Publikováno v: Journal of Medicinal Chemistry. 43:4542-4551

Reaction of perfluoroalkyl/arylsulfonyl chlorides or perfluoroalkyl/arylcarbonyl chlorides with aromatic/heterocyclic sulfonamides possessing a free amino/imino/hydrazino/hydroxy group afforded compounds with the general formula C(x)()F(y)()Z-A-SO(2)

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https://doi.org/10.1021/jm000296j

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Carbonic anhydrase inhibitors – Part 78. Synthesis of water-soluble sulfonamides incorporating β-alanyl moieties, possessing long lasting-intraocular pressure lowering properties via the topical route

Autor: Fabrizio Briganti, Andrea Scozzafava, Francesco Mincione, Luca Menabuoni, Claudiu T. Supuran, Giovanna Mincione

Publikováno v: European Journal of Medicinal Chemistry. 35:309-321

Reaction of 26 aromatic/heterocyclic sulfonamides containing amino, imino, hydrazino or hydroxyl groups with N-tert-butyloxycarbonyl-beta-alanine (Boc-beta-ala; Boc = t-butoxycarbonyl) in the presence of carbodiimide derivatives afforded, after remov

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https://doi.org/10.1016/s0223-5234(00)00130-6

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Carbonic anhydrase inhibitors. Part 79

Autor: Andrea Scozzafava, Luca Menabuoni, Giovanna Mincione, Fabrizio Briganti, Claudiu T. Supuran, Francesco Mincione

Publikováno v: European Journal of Pharmaceutical Sciences. 9:185-199

Reaction of 26 aromatic/heterocyclic sulfonamides containing amino, imino, hydrazino or hydroxyl groups with N-tert-butoxycarbonyl-γ-aminobutyric acid (Boc-GABA; Boc=t-butoxycarbonyl) in the presence of carbodiimide derivatives, afforded after remov

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https://doi.org/10.1016/s0928-0987(99)00052-4

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