Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Francesco Lescai"'
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14512 (2022)
Horizontal gene transfer (HGT) is well described in prokaryotes: it plays a crucial role in evolution, and has functional consequences in insects and plants. However, less is known about HGT in humans. Studies have reported bacterial integrations in
Externí odkaz:
https://doaj.org/article/f906982b442549f6843719e8b2594771
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
BackgroundAging is a complex phenotype influenced by a combination of genetic and environmental factors. Although many studies addressed its cellular and physiological age-related changes, the molecular causes of aging remain undetermined. Considerin
Externí odkaz:
https://doaj.org/article/50bd80074202495d8aaf0ea2bc3c4724
Autor:
Francesco Lescai, Elena Marasco, Chiara Bacchelli, Philip Stanier, Vilma Mantovani, Philip Beales
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 2, Iss 1, Pp 58-63 (2014)
Abstract The choice of an appropriate variant calling pipeline for exome sequencing data is becoming increasingly more important in translational medicine projects and clinical contexts. Within GOSgene, which facilitates genetic analysis as part of a
Externí odkaz:
https://doaj.org/article/f1a307f7378043d2b33d687aefbc50c7
Autor:
Jesper Buchhave Poulsen, Francesco Lescai, Jakob Grove, Marie Bækvad-Hansen, Michael Christiansen, Christian Munch Hagen, Julian Maller, Christine Stevens, Shenting Li, Qibin Li, Jihua Sun, Jun Wang, Merete Nordentoft, Thomas Mears Werge, Preben Bo Mortensen, Anders Dupont Børglum, Mark Daly, David Michael Hougaard, Jonas Bybjerg-Grauholm, Mads Vilhelm Hollegaard
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153253 (2016)
Stored neonatal dried blood spot (DBS) samples from neonatal screening programmes are a valuable diagnostic and research resource. Combined with information from national health registries they can be used in population-based studies of genetic disea
Externí odkaz:
https://doaj.org/article/b7d81261b38b483baebf2902853bbb78
Autor:
Francesco Lescai, Silvia Bonfiglio, Chiara Bacchelli, Estelle Chanudet, Aoife Waters, Sanjay M Sisodiya, Dalia Kasperavičiūtė, Julie Williams, Denise Harold, John Hardy, Robert Kleta, Sebahattin Cirak, Richard Williams, John C Achermann, John Anderson, David Kelsell, Tom Vulliamy, Henry Houlden, Nicholas Wood, Una Sheerin, Gian Paolo Tonini, Donna Mackay, Khalid Hussain, Jane Sowden, Veronica Kinsler, Justyna Osinska, Tony Brooks, Mike Hubank, Philip Beales, Elia Stupka
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51292 (2012)
Recent advances in genomics technologies have spurred unprecedented efforts in genome and exome re-sequencing aiming to unravel the genetic component of rare and complex disorders. While in rare disorders this allowed the identification of novel caus
Externí odkaz:
https://doaj.org/article/a5b135f4e56341478420eb0c8b20e8d2
Autor:
Francesca Marchegiani, Liana Spazzafumo, Maurizio Cardelli, Mauro Provinciali, Francesco Lescai, Claudio Franceschi, Roberto Antonicelli
Publikováno v:
Journal of Lipids, Vol 2012 (2012)
It is well known that serum paraoxonase (PON1) plays an important role in the protection of LDL from oxidation. PON1 55 polymorphism is currently investigated for its possible involvement in cardiovascular diseases. The objective of our study is to v
Externí odkaz:
https://doaj.org/article/ecf5d9695f1d42aba178859b779181f1
Autor:
Francesco Lescai, Claudio Franceschi
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11876 (2010)
A consistent debate is ongoing on genome-wide association studies (GWAs). A key point is the capability to identify low-penetrance variations across the human genome. Among the phenomena reducing the power of these analyses, phenocopy level (PE) hamp
Externí odkaz:
https://doaj.org/article/da569ff11f0e43f0b40492c25fcb2883
Deep learning has already revolutionised the way we process a wide range of data, in many areas of our daily life. The ability to learn abstractions and relationships from heterogeneous data, has provided impressively accurate prediction and classifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc704f1c7474c4e305c856592010c7e0
Horizontal gene transfer (HGT) is well described in prokaryotes, it plays a crucial role in evolution, and has functional consequences in insects and plants: less is known about HGT in Humans. Studies have reported bacterial integrations in cancer pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff8448bff1cc34b11f228009d0454719
https://doi.org/10.1101/2022.10.24.513588
https://doi.org/10.1101/2022.10.24.513588
Autor:
Eleonora Cappelletti, Francesca M Piras, Lorenzo Sola, Marco Santagostino, Wasma A Abdelgadir, Elena Raimondi, Francesco Lescai, Solomon G Nergadze, Elena Giulotto
Publikováno v:
Molecular biology and evolution. 39(8)
Centromeres are epigenetically specified by the histone H3 variant CENP-A and typically associated with highly repetitive satellite DNA. We previously discovered natural satellite-free neocentromeres in Equus caballus and Equus asinus. Here, through