Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Francesco Lai"'
Autor:
Manuela Pasella, Fabio Pisano, Barbara Cannas, Alessandra Fanni, Eleonora Cocco, Jessica Frau, Francesco Lai, Stefano Mocci, Roberto Littera, Sabrina Rita Giglio
Publikováno v:
Frontiers in Neuroinformatics, Vol 17 (2023)
IntroductionMultiple sclerosis (MS) is a persistent neurological condition impacting the central nervous system (CNS). The precise cause of multiple sclerosis is still uncertain; however, it is thought to arise from a blend of genetic and environment
Externí odkaz:
https://doaj.org/article/02d987cb554048829836e8fc053528c9
Autor:
Luca Casula, Rosa Pireddu, Maria Cristina Cardia, Elena Pini, Donatella Valenti, Michele Schlich, Chiara Sinico, Salvatore Marceddu, Nina Dragićević, Anna Maria Fadda, Francesco Lai
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2308 (2023)
Applying a formulation on the skin represents a patient-acceptable and therapeutically effective way to administer drugs locally and systemically. However, the stratum corneum stands as an impermeable barrier that only allows a very limited number of
Externí odkaz:
https://doaj.org/article/2b2326eefe3d41fa8c845a2b030e602d
Autor:
Marco Ruggeri, Rita Sánchez-Espejo, Luca Casula, Giuseppina Sandri, Luana Perioli, Maria Cristina Cardia, Francesco Lai, César Viseras
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1253 (2023)
Bentonite or palygorskite-based hydrogels have recently been suggested as a strategy to increase bioavailability and control the retention and release of therapeutic candidates. In this work, clay-based hydrogels loaded with diclofenac acid nanocryst
Externí odkaz:
https://doaj.org/article/426207bd9c944e9296a2e4ec5b6c07f1
Autor:
Marco Ruggeri, Rita Sánchez-Espejo, Luca Casula, Raquel de Melo Barbosa, Giuseppina Sandri, Maria Cristina Cardia, Francesco Lai, César Viseras
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2836 (2022)
The poor water solubility of a significant number of active pharmaceutical ingredients (API) remains one of the main challenges in the drug development process, causing low bioavailability and therapeutic failure of drug candidates. Curcumin is a wel
Externí odkaz:
https://doaj.org/article/5ac44483186f470ba04e1dc8fd46dbff
Autor:
Giorgia Ailuno, Alice Balboni, Gabriele Caviglioli, Francesco Lai, Federica Barbieri, Irene Dellacasagrande, Tullio Florio, Sara Baldassari
Publikováno v:
Cells, Vol 11, Iss 24, p 4029 (2022)
Boron neutron capture therapy is a low-invasive cancer therapy based on the neutron fission process that occurs upon thermal neutron irradiation of 10B-containing compounds; this process causes the release of alpha particles that selectively damage c
Externí odkaz:
https://doaj.org/article/6b48c053c69245bb8d28390d2e56bc05
Autor:
Michele Schlich, Luca Casula, Aurora Musa, Rosa Pireddu, Giulia Pitzanti, Maria Cristina Cardia, Donatella Valenti, Salvatore Marceddu, Anna Maria Fadda, Maria Antonietta De Luca, Chiara Sinico, Francesco Lai
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1085 (2022)
Needle-free liquid jet injectors are medical devices used to administer pharmaceutical solutions through the skin. Jet injectors generate a high-speed stream of liquid medication that can puncture the skin and deliver the drug to the underlying tissu
Externí odkaz:
https://doaj.org/article/4318cd979142402593fb507e131a1410
Autor:
Luca Casula, Francesco Lai, Elena Pini, Donatella Valenti, Chiara Sinico, Maria Cristina Cardia, Salvatore Marceddu, Giorgia Ailuno, Anna Maria Fadda
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1300 (2021)
Curcumin has shown a potential extraordinary activity as an add-on ingredient in asthma treatment, due to its immunomodulatory and anti-inflammatory mechanism of action. However, its low water solubility and bioavailability lead to a poor therapeutic
Externí odkaz:
https://doaj.org/article/5bd777547c0c49cf87fff4f6fcfb38e2
Autor:
Lucia Montenegro, Ludovica Maria Santagati, Maria Grazia Sarpietro, Francesco Castelli, Annamaria Panico, Edy Angela Siciliano, Francesco Lai, Donatella Valenti, Chiara Sinico
Publikováno v:
Pharmaceutics, Vol 13, Iss 7, p 1027 (2021)
Lipid nanoparticles (LNPs) have been proposed as carriers for drug skin delivery and targeting. As LNPs effectiveness could be increased by the addition of chemical penetration enhancers (PE), in this work, the feasibility of incorporating PE into LN
Externí odkaz:
https://doaj.org/article/48c9ae988df44e79814e8f99a05bf620
Autor:
Francesco Lai, Flavia Cucca, Roberto Frau, Francesco Corrias, Michele Schlich, Pierluigi Caboni, Anna Maria Fadda, Valentina Bassareo
Publikováno v:
Frontiers in Psychiatry, Vol 9 (2018)
Orexin neurons originate in the lateral and dorsomedial hypothalamus and perifornical area and produce two different neuropeptides: orexin A (OxA) and orexin B (OxB), which activate OxR1 and OxR2 receptors. In the lateral hypothalamus (LH) orexin neu
Externí odkaz:
https://doaj.org/article/7474673fcc8b453ba67ad090d0bf14f9
Publikováno v:
Cells, Vol 9, Iss 12, p 2569 (2020)
Exosomes are endosome-derived nanovesicles produced by healthy as well as diseased cells. Their proteic, lipidic and nucleic acid composition is related to the cell of origin, and by vehiculating bioactive molecules they are involved in cell-to-cell
Externí odkaz:
https://doaj.org/article/327e5e19643a4a0c897db53960a9e76a