Výsledky vyhledávání - "Francesco Guarasci"

Akademický článek

Unveiling the Burden of Interactions Among Clinical Risk Factors for 1-Year Mortality in Hospitalized Older Patients

Autor: Fabrizia Lattanzio, Valentina Corigliano, Luca Soraci, Alessia Fumagalli, Graziano Onder, Stefano Volpato, Antonio Cherubini, Carmelinda Ruggiero, Annalisa Cozza, Francesco Guarasci, Andrea Corsonello

Publikováno v: Frontiers in Medicine, Vol 8 (2021)

Background: Hospitalized older patients are particularly exposed to adverse health outcomes.Objective: In this study, we aimed at investigating the prognostic interactions between disability in basic activities of daily living (BADL), cognitive impai

Externí odkaz: https://doaj.org/article/b434bc810c194de1a5e1d64779aff24c

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Design and methodology of the chronic kidney disease as a dysmetabolic determinant of disability among older people (CKD-3D) study: a multicenter cohort observational study

Autor: Fabrizia Lattanzio, Paolo Fabbietti, Francesco U.S. Mattace-Raso, Sonia D'Alia, Francesco Guarasci, Luna Zerbinati, Lisanne Tap, Valentina Corigliano, Annalisa Cozza, Mirko Di Rosa, Andrea Corsonello, Luca Soraci, Marcello Maggio

Publikováno v: Aging clinical and experimental research, 33(9), 2445-2451. Springer-Verlag
Aging Clinical and Experimental Research

Background: Chronic kidney disease (CKD) is a common condition in older people and represents a global health issue since it increases the risk of associated comorbidities and all-cause mortality. Furthermore, older people with reduced renal function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06625cb629854b3378f07ae6933ad626
https://doi.org/10.1007/s40520-020-01755-1

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Individual DNA Methylation Profile is Correlated with Age and can be Targeted to Modulate Healthy Aging and Longevity

Autor: Alberto Montesanto, Patrizia D'Aquila, Dina Bellizzi, Francesco Guarasci, Andrea Corsonello, Giuseppe Passarino

Publikováno v: Current Pharmaceutical Design. 25:4139-4149

Patterns of DNA methylation, the best characterized epigenetic modification, are modulated by aging. In humans, different studies at both site-specific and genome-wide levels have reported that modifications of DNA methylation are associated with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bfc4d855ab9fab2df64ed6a6a6509b7
https://doi.org/10.2174/1381612825666191112095655

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Multi-Tissue DNA Methylation Remodeling at Mitochondrial Quality Control Genes According to Diet in Rat Aging Models

Autor: Patrizia D'Aquila, Dina Bellizzi, Francesco Guarasci, Maurizio Mandalà, Francesco De Rango, Giuseppe Passarino, Andrea Corsonello

Publikováno v: Nutrients
Volume 12
Issue 2
Nutrients, Vol 12, Iss 2, p 460 (2020)

An adequate mitochondrial quality control system ensures the maintenance of a healthy mitochondrial pool so as to slow down the progressive accumulation of damage affecting mitochondrial function during aging and diseases. The amount and quality of n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be608d640a3bb62e68888f4045a6f9b

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Hand Grip Strength May Affect the Association Between Anticholinergic Burden and Mortality Among Older Patients Discharged from Hospital

Autor: Maurizio Leonardo Guerrieri, Fabrizia Lattanzio, Andrea Corsonello, Graziano Onder, Antonio Cherubini, Daniele Colombo, Francesco Guarasci, Paolo Fabbietti, Stefano Volpato, Carmelinda Ruggiero, Lucia Crescibene, Luca Soraci, Ramona Caloiero, Sonia D'Alia, Luca Bartucci

The relationship between anticholinergic burden and mortality is unclear, and the impact of anticholinergic burden on prognosis may vary in the presence of other conditions common in old age. We aimed to investigate the role of hand grip strength as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac48ac9e14dcc925c47f43c060c1dcc
http://hdl.handle.net/11391/1489913

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Cognitive impairment, chronic kidney disease, and 1-year mortality in older patients discharged from acute care hospital

Autor: Federica Lenci, Andrea Corsonello, Sonia D'Alia, Stefano Volpato, Carmelinda Ruggiero, Fabrizia Lattanzio, Graziano Onder, Mirko Di Rosa, Luca Soraci, Elisa Pierpaoli, Maddalena Ricci, Francesco Guarasci, Antonio Cherubini

Publikováno v: Journal of Clinical Medicine
Journal of Clinical Medicine, Vol 9, Iss 2202, p 2202 (2020)
Volume 9
Issue 7

The prognostic interaction between chronic kidney disease (CKD) and cognitive impairment is still to be elucidated. We investigated the potential interaction of overall cognitive impairment or defective constructional praxis and CKD in predicting 1-y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90421407747b3211ba71c632684ae39
http://hdl.handle.net/11392/2473182

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Aging and nutrition induce tissue-specific changes on global DNA methylation status in rats

Autor: Dina Bellizzi, Maurizio Mandalà, Patrizia D'Aquila, Andrea Corsonello, Giuseppe Passarino, Francesco Guarasci, Fabrizia Lattanzio, Sabrina Garasto

Publikováno v: Mechanisms of Ageing and Development. 174:47-54

A number of epigenetic studies have demonstrated that DNA methylation patterns exhibit a tissue specificity, but not much has been done to highlight the extent of this phenomenon. Moreover, it is unknown how external factors modulate the plasticity o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f14be44f4b4014250a0ef8f82c0764
https://doi.org/10.1016/j.mad.2018.02.001

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Epigenetic signature: implications for mitochondrial quality control in human aging

Autor: Francesco Guarasci, Patrizia D'Aquila, Francesco De Rango, Giuseppe Passarino, Alberto Montesanto, Dina Bellizzi

Publikováno v: Aging (Albany NY)

Maintenance of functional mitochondria is essential to prevent damage leading to aging and diseases. What is more, the research of biomarkers of aging is focusing on better predicting functional capability along the lifetime beyond chronological age.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f426b7e46d5127c782bbdcd1a0c1470
https://pubmed.ncbi.nlm.nih.gov/30787202

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Prognosis and Interplay of Cognitive Impairment and Sarcopenia in Older Adults Discharged from Acute Care Hospitals

Autor: Paolo Fabbietti, Francesco Guarasci, Stefano Volpato, Carmelinda Ruggiero, Antonio Cherubini, Fabrizia Lattanzio, Davide L. Vetrano, Giovanni Renato Riccardi, Lucia Mancinelli, Daniele Castellani, Andrea Corsonello, Elisa Zengarini, Graziano Onder, Robertina Giacconi

Publikováno v: Journal of Clinical Medicine
Volume 8
Issue 10
Journal of Clinical Medicine, Vol 8, Iss 10, p 1693 (2019)

Sarcopenia and cognitive impairment are associated with an increased risk of negative outcomes, but their prognostic interplay has not been investigated so far. We aimed to investigate the prognostic interaction of sarcopenia and cognitive impairment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6c5106440935724d38eaa11b5d49d4
http://hdl.handle.net/11391/1460220

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Epigenetics and Ageing

Autor: Francesco Guarasci, Giuseppe Passarino, Giuseppina Rose, Dina Bellizzi, Francesca Iannone

Publikováno v: Centenarians ISBN: 9783030207618

The term epigenetics refers to the heritable alterations not due to changes in DNA sequences, which modulate the individual phenotype by modulating the expression and the activity of genes (Armstrong, Epigenetics, Garland Science, New York, 2013; Pin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73184d1bfb269bbdb1a6b979f9db31eb
https://doi.org/10.1007/978-3-030-20762-5_7

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