Zobrazeno 1 - 10
of 303
pro vyhledávání: '"Francesco Falciani"'
Autor:
Barry Murphy, Sally Grimshaw, Michael Hoptroff, Sarah Paterson, David Arnold, Andrew Cawley, Suzanne E. Adams, Francesco Falciani, Tony Dadd, Richard Eccles, Alex Mitchell, William F. Lathrop, Diana Marrero, Galina Yarova, Ana Villa, John S. Bajor, Lin Feng, Dawn Mihalov, Andrew E. Mayes
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Xerosis, commonly referred to as dry skin, is a common dermatological condition affecting almost a third of the population. Successful treatment of the condition traditionally involves the application of cosmetic products facilitating the mo
Externí odkaz:
https://doaj.org/article/d02ee2f7139b47fd9be8cc5f8d23ff8d
Autor:
Louise Y. Takeshita, Peter K. Davidsen, John M. Herbert, Philipp Antczak, Matthijs K. C. Hesselink, Patrick Schrauwen, S. John Weisnagel, Jeremy M. Robbins, Robert E. Gerszten, Sujoy Ghosh, Mark A. Sarzynski, Claude Bouchard, Francesco Falciani
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Despite good adherence to supervised endurance exercise training (EET), some individuals experience no or little improvement in peripheral insulin sensitivity. The genetic and molecular mechanisms underlying this phenomenon are currently not
Externí odkaz:
https://doaj.org/article/9a3774b2c4754f49983653dd5d84465b
Autor:
Lindsay S. Cooley, Justine Rudewicz, Wilfried Souleyreau, Andrea Emanuelli, Arturo Alvarez-Arenas, Kim Clarke, Francesco Falciani, Maeva Dufies, Diether Lambrechts, Elodie Modave, Domitille Chalopin-Fillot, Raphael Pineau, Damien Ambrosetti, Jean-Christophe Bernhard, Alain Ravaud, Sylvie Négrier, Jean-Marc Ferrero, Gilles Pagès, Sebastien Benzekry, Macha Nikolski, Andreas Bikfalvi
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-21 (2021)
Abstract Background Renal Cell Carcinoma (RCC) is difficult to treat with 5-year survival rate of 10% in metastatic patients. Main reasons of therapy failure are lack of validated biomarkers and scarce knowledge of the biological processes occurring
Externí odkaz:
https://doaj.org/article/cee420b826cb4bfbb98850145497e573
Autor:
Jaanika Kronberg, Jonathan J. Byrne, Jeroen Jansen, Philipp Antczak, Adam Hines, John Bignell, Ioanna Katsiadaki, Mark R. Viant, Francesco Falciani
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The monitoring of anthropogenic chemicals in the aquatic environment including their potential effects on aquatic organisms, is important for protecting life under water, a key sustainable development goal. In parallel with monitoring the co
Externí odkaz:
https://doaj.org/article/482d7638e4254c6588d577da7644f49b
Autor:
Gina L. Eagle, John M. J. Herbert, Jianguo Zhuang, Melanie Oates, Umair T. Khan, Neil R. Kitteringham, Kim Clarke, B. Kevin Park, Andrew R. Pettitt, Rosalind E. Jenkins, Francesco Falciani
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Chronic lymphocytic leukaemia (CLL) exhibits variable clinical course and response to therapy, but the molecular basis of this variability remains incompletely understood. Data independent acquisition (DIA)-MS technologies, such as SWATH (Se
Externí odkaz:
https://doaj.org/article/b0b4a251ceac451c8bcb635f0d6ce38e
Autor:
Maila Becconi, Simona De Zio, Francesco Falciani, Marzia Santamaria, Marco Malferrari, Stefania Rapino
Publikováno v:
Cancers, Vol 15, Iss 4, p 1327 (2023)
Current cancer research is limited by the availability of reliable in vivo and in vitro models that are able to reproduce the fundamental hallmarks of cancer. Animal experimentation is of paramount importance in the progress of research, but it is be
Externí odkaz:
https://doaj.org/article/045728459b3e4e36b6d1aacf852f7ddc
Autor:
Casimiro A. Curbelo Montanez, Paul Fergus, Carl Chalmers, Nurul Hashimah Ahamed Hassain Malim, Basma Abdulaimma, Denis Reilly, Francesco Falciani
Publikováno v:
IEEE Access, Vol 8, Pp 112379-112392 (2020)
One of the most important challenges in the analysis of high-throughput genetic data is the development of efficient computational methods to identify statistically significant Single Nucleotide Polymorphisms (SNPs). Genome-wide association studies (
Externí odkaz:
https://doaj.org/article/9ba4ee7d8f524ef4b3754f396f0d393b
Autor:
Thomas Daubon, Céline Léon, Kim Clarke, Laetitia Andrique, Laura Salabert, Elodie Darbo, Raphael Pineau, Sylvaine Guérit, Marlène Maitre, Stéphane Dedieu, Albin Jeanne, Sabine Bailly, Jean-Jacques Feige, Hrvoje Miletic, Marco Rossi, Lorenzo Bello, Francesco Falciani, Rolf Bjerkvig, Andréas Bikfalvi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Thrombospondin-1 (THSB1) is a component of the ECM with a role in regulating cancer development and tumour vasculature. Here, the authors show that TGF-beta-induced THBS1 expression contributes to the invasive behaviour of GBM cells and promotes resi
Externí odkaz:
https://doaj.org/article/0213114feac44243930602814fc59d30
Autor:
Kim Clarke, Sara Ricciardi, Tim Pearson, Izwan Bharudin, Peter K. Davidsen, Michela Bonomo, Daniela Brina, Alessandra Scagliola, Deborah M. Simpson, Robert J. Beynon, Farhat Khanim, John Ankers, Mark A. Sarzynski, Sujoy Ghosh, Addolorata Pisconti, Jan Rozman, Martin Hrabe de Angelis, Chris Bunce, Claire Stewart, Stuart Egginton, Mark Caddick, Malcolm Jackson, Claude Bouchard, Stefano Biffo, Francesco Falciani
Publikováno v:
Cell Reports, Vol 21, Iss 6, Pp 1507-1520 (2017)
Summary: Regular endurance training improves muscle oxidative capacity and reduces the risk of age-related disorders. Understanding the molecular networks underlying this phenomenon is crucial. Here, by exploiting the power of computational modeling,
Externí odkaz:
https://doaj.org/article/56b43239ccf74aeabfd363d761f08299
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 1, p e1006685 (2019)
Osteoarthritis (OA) is a degenerative condition caused by dysregulation of multiple molecular signalling pathways. Such dysregulation results in damage to cartilage, a smooth and protective tissue that enables low friction articulation of synovial jo
Externí odkaz:
https://doaj.org/article/1e922eac8794470196aaaa3edf65799a