Stability of an aggregation-prone partially folded state of human profilin-1 correlates with aggregation propensity

Autor: Francesco Di Piro, Chiara Aloise, Edoardo Del Poggetto, Francesco Bemporad, Ludovica Gori, Francesco Malatesta, Angelo Toto, Stefano Gianni, Fabrizio Chiti

Publikováno v: The Journal of biological chemistry
293 (2018): 10303–10313. doi:10.1074/jbc.RA118.002087
info:cnr-pdr/source/autori:Del Poggetto E.; Toto A.; Aloise C.; Di Piro F.; Gori L.; Malatesta F.; Gianni S.; Chiti F.; Bemporad F./titolo:Stability of an aggregation-prone partially folded state of human profilin-1 correlates with aggregation propensity/doi:10.1074%2Fjbc.RA118.002087/rivista:The Journal of biological chemistry (Print)/anno:2018/pagina_da:10303/pagina_a:10313/intervallo_pagine:10303–10313/volume:293

A set of missense mutations in the gene encoding profilin-1 has been linked to the onset of familial forms of ALS (fALS), also known as Lou Gehrig's disease. The pathogenic potential of these mutations is linked to the formation of intracellular incl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419e241ca6d1969180521b6f7faa8a67
https://europepmc.org/articles/PMC6028969/