Výsledky vyhledávání - "Francesco Calvaruso"

Coadministration of Telomerase Genetic Vaccine and a Novel TLR9 Agonist in Nonhuman Primates

Autor: Saverio Giampaoli, Nicola La Monica, Daniela Peruzzi, Francesco Calvaruso, Gennaro Ciliberto, Giuseppe Mesiti, Elisa Scarselli, Ekambar R. Kandimalla, Sudhir Agrawal, Carmela Mennuni, Sridhar Dharmapuri, Gaetano Barbato, Luigi Aurisicchio

Publikováno v: Molecular Therapy. 17:1804-1813

The human telomerase reverse transcriptase (hTERT) is an attractive target for human cancer vaccination because its expression is reactivated in most human tumors. We have evaluated the ability of DNA electroporation (DNA-EP) and adenovirus serotype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663ad7a4890996228f4105104f764d3e
https://doi.org/10.1038/mt.2009.165

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Autoimmune B-cell lymphopenia after successful adoptive therapy with telomerase-specific T lymphocytes

Autor: Carmela Mennuni, Barbara Cipriani, Elisa Peranzoni, Vincenzo Bronte, Francesco Calvaruso, Paola Zanovello, Tania Pannellini, Piero Musiani, Elisa Scarselli, Raffaele De Palma, Stefano Ugel, Lucia Ricci-Vitiani, Manuela Iezzi

Publikováno v: Blood. 115(7)

Telomerase reverse transcriptase (TERT) is a good candidate for cancer immunotherapy because it is overexpressed in 85% of all human tumors and implicated in maintenance of the transformed phenotype. TERT-based cancer vaccines have been shown to be s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cd189f5a3a29a25f1f99cb5728d79e
https://pubmed.ncbi.nlm.nih.gov/20167708

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Gene therapy of Hunter syndrome: Evaluation of the efficiency of muscle electro genetransfer for the production and release of recombinant iduronate-2-sulfatase (IDS)

Autor: Adelaide Friso, Carmela Mennuni, Rosella Tomanin, Francesco Calvaruso, N. La Monica, Alessandra Zanetti, Franco Zacchello, Maurizio Scarpa, Oriano Marin

Publikováno v: BBA-Molecular Basis of Disease
BBA-Molecular Basis of Disease, Elsevier, 2008, 1782 (10), pp.574. 〈10.1016/j.bbadis.2008.07.001〉

Mucopolysaccharidosis type II (MPSII) is an inherited disorder due to a deficiency of the lysosomal enzyme iduronate-2-sulfatase (IDS). The disease is characterized by a considerable deposition of heparan- and dermatan-sulfate, causing a general impa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e107b21087db27a27977d6ca92f3f3
http://hdl.handle.net/11577/2274843

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Immunogenicity and safety of a DNA prime/adenovirus boost vaccine against rhesus CEA in nonhuman primates

Autor: Nicola La Monica, Luigi Aurisicchio, Paolo Monaci, Gennaro Ciliberto, Francesco Calvaruso, Maurizio Nuzzo, Carmela Mennuni, Fabio Palombo, Patrizia Giannetti, Barbara Cipriani

Publikováno v: International journal of cancer. 120(11)

Scaling up experimental protocols from rodents to humans is often not a straightforward procedure, and this particularly applies to cancer vaccines, where vaccination technology must be especially effective to overcome a variety of immune suppressive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312d6bb84e74d6ff5eddfa825401a889
https://pubmed.ncbi.nlm.nih.gov/17304509

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Genetic vaccines against Ep-CAM break tolerance to self in a limited subset of subjects: initial identification of predictive biomarkers

Autor: Francesco Calvaruso, Fabio Palombo, Leonardo Elia, Valentina Salucci, Alessia Scarito, Mariangela Storto, Carmela Mennuni, Gennaro Ciliberto, Silvia Podda, Nicola La Monica, Luigi Aurisicchio

Publikováno v: European journal of immunology. 36(5)

The epithelial cell adhesion molecule, Ep-CAM, has been historically considered a target of passive immunotherapy using monoclonal antibodies, and more recently, of a first Pox-vector-based cancer vaccine Phase I trial in colorectal cancer patients.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca1a0240e5258489cfead53e2e3de21
https://pubmed.ncbi.nlm.nih.gov/16639707

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CD8+ T-cell tolerance can be broken by an adenoviral vaccine while CD4+ T-cell tolerance is broken by additional co-administration of a Toll-like receptor ligand

Autor: N. La Monica, Valentina Salucci, Francesco Calvaruso, Gennaro Ciliberto, Elisa Scarselli, Carmela Mennuni, R. Cerino, P. Neuner

Publikováno v: Scandinavian journal of immunology. 63(1)

T-cell tolerance to tumor antigens is a considerable challenge to cancer immunotherapy. The existence of a murine model transgenic for human carcinoembryonic antigen (CEA) allows CEA vaccination efficacy to be studied in a physiologically tolerant co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c2494e0ef0ec9a71356ab667843bfa
https://pubmed.ncbi.nlm.nih.gov/16398699

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Efficient induction of T-cell responses to carcinoembryonic antigen by a heterologous prime-boost regimen using DNA and adenovirus vectors carrying a codon usage optimized cDNA

Autor: Luigi Aurisicchio, Andrea Facciabene, Carmela Mennuni, Nicola La Monica, Francesco Calvaruso, Gennaro Ciliberto, Mariangela Storto, Elisa Scarselli

Publikováno v: International journal of cancer. 117(3)

The immunogenic properties of plasmid DNA and recombinant adenovirus (Ad) encoding the carcinoembryonic antigen (CEA) were examined in mice by measuring both the amplitude and type of immune response, and the immunogenicity of codon usage optimized c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899991f982a54a3ecab6791af9164875
https://pubmed.ncbi.nlm.nih.gov/15906358

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Gene electro-transfer of an improved erythropoietin plasmid in mice and non-human primates

Autor: Immacolata Zampaglione, Elena Fattori, Manuela Cappelletti, Gennaro Ciliberto, Patrizia Costa, Nicola La Monica, Gemma Perretta, Gabriella Rizzuto, Francesco Calvaruso, Carmela Mennuni, Mirko Arcuri

Publikováno v: The journal of gene medicine 7/2 (2005): 228–236. doi:10.1002/jgm.652
info:cnr-pdr/source/autori:Fattori E.1, Cappelletti M.2, Zampaglione I.3, Mennuni C.4, Calvaruso F.5, Arcuri M.6, Rizzuto G.7, Costa P.8, Perretta G.9, Ciliberto G.10, La Monica N.11/titolo:Gene electro-transfer of an improved erythropoietin plasmid in mice and non-human primates./doi:10.1002%2Fjgm.652/rivista:The journal of gene medicine/anno:2005/pagina_da:228/pagina_a:236/intervallo_pagine:228–236/volume:7%2F2

BACKGROUND: Anemia due to impaired erythropoietin (EPO) production is associated with kidney failure. Recombinant proteins are commonly administered to alleviate the symptoms of this dysfunction, whereas gene therapy approaches envisaging the deliver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a16fdcb114094b3e29ce8ed8501167d
https://pubmed.ncbi.nlm.nih.gov/15515133

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Hyaluronidase increases electrogene transfer efficiency in skeletal muscle

Autor: Ernesta Dammassa, Francesco Calvaruso, Gabriella Rizzuto, Gennaro Ciliberto, Elena Fattori, Nicola La Monica, Immacolata Zampaglione, C. Daniela Rinaudo, Carmela Mennuni

Publikováno v: Human gene therapy. 13(3)

Electrogene transfer (EGT) of plasmid DNA into skeletal muscle is a promising strategy for the treatment of muscle disorders and for the systemic secretion of therapeutic proteins. We report here that preinjecting hyaluronidase (HYAse) significantly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0bae2701b4276991f8201d2a4fc5ce
https://pubmed.ncbi.nlm.nih.gov/11860703

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