Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Francesco Bonì"'
Autor:
Elisa Fagnani, Francesco Bonì, Pierfausto Seneci, Davide Gornati, Luca Muzio, Eloise Mastrangelo, Mario Milani
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1088-1093 (2024)
The stabilization of the retromer protein complex can be effective in the treatment of different neurological disorders. Following the identification of bis-1,3-phenyl guanylhydrazone 2a as an effective new compound for the treatment of amyotrophic l
Externí odkaz:
https://doaj.org/article/1cd32817805240faa098c6e2c29a04ba
Autor:
Kevin P. Guay, Roberta Ibba, J.L. Kiappes, Snežana Vasiljević, Francesco Bonì, Maria De Benedictis, Ilaria Zeni, James D. Le Cornu, Mario Hensen, Anu V. Chandran, Anastassia L. Kantsadi, Alessandro T. Caputo, Juan I. Blanco Capurro, Yusupha Bayo, Johan C. Hill, Kieran Hudson, Andrea Lia, Juliane Brun, Stephen G. Withers, Marcelo Martí, Emiliano Biasini, Angelo Santino, Matteo De Rosa, Mario Milani, Carlos P. Modenutti, Daniel N. Hebert, Nicole Zitzmann, Pietro Roversi
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107919- (2023)
Summary: Misfolded glycoprotein recognition and endoplasmic reticulum (ER) retention are mediated by the ER glycoprotein folding quality control (ERQC) checkpoint enzyme, UDP-glucose glycoprotein glucosyltransferase (UGGT). UGGT modulation is a promi
Externí odkaz:
https://doaj.org/article/65e937022caf475ebc2513beca012f73
Autor:
Michele Fiore, Michele Mosconi, Francesco Bonì, Alice Parodi, Annalisa Salis, Bruno Tasso, Eloise Mastrangelo, Enrico Millo, Federica Cossu
Publikováno v:
Molecules, Vol 28, Iss 1, p 446 (2023)
Inhibitor of Apoptosis Proteins (IAPs) are validated targets for cancer therapy, and the deregulation of their activities within the NF-κB pathway correlates with chemoresistance events, even after treatment with IAPs-antagonists in the clinic (Smac
Externí odkaz:
https://doaj.org/article/29fc0bce5e904e8f953a500626187fa6
Autor:
Rafaela Milan Bonotto, Francesco Bonì, Mario Milani, Antonio Chaves-Sanjuan, Silvia Franze, Francesca Selmin, Tommaso Felicetti, Martino Bolognesi, Soultana Konstantinidou, Monica Poggianella, Chantal L. Márquez, Federica Dattola, Monica Zoppè, Giuseppe Manfroni, Eloise Mastrangelo, Alessandro Marcello
Publikováno v:
Viruses, Vol 14, Iss 6, p 1157 (2022)
Pyridobenzothiazolone derivatives are a promising class of broad-spectrum antivirals. However, the mode of action of these compounds remains poorly understood. The HeE1-17Y derivative has already been shown to be a potent compound against a variety o
Externí odkaz:
https://doaj.org/article/b90d49d34ce949a9a2ae978d6def6752
Autor:
Francesco Bonì, Valerio Marino, Carlo Bidoia, Eloise Mastrangelo, Alberto Barbiroli, Daniele Dell’Orco, Mario Milani
Publikováno v:
Biomolecules, Vol 10, Iss 10, p 1408 (2020)
The guanylyl cyclase-activating protein 1, GCAP1, activates or inhibits retinal guanylyl cyclase (retGC) depending on cellular Ca2+ concentrations. Several point mutations of GCAP1 have been associated with impaired calcium sensitivity that eventuall
Externí odkaz:
https://doaj.org/article/7980caf8e31f4ccc89f69f09bdaa2473
Autor:
Francesco Bonifacio
Publikováno v:
Tecnoscienza, Vol 15, Iss 1, Pp 21-38 (2024)
The debate on digital labour platforms (DLPs) postulates that algorithms engineer pervasive organizational control, but it often observes that workers can evade and resist this control by manipulating algorithms’ decisions. This article aims to unp
Externí odkaz:
https://doaj.org/article/903ed87b7d3045a18be08c840dd633a8
Autor:
Mario Milani, Edoardo Schneider, Francesco Bonì, Irene Arduino, Manuela Donalisio, Rafaela Milan Bonotto, David Lembo, Alessandro Marcello, Eloise Mastrangelo
Publikováno v:
Antiviral research
189 (2021). doi:10.1016/j.antiviral.2021.105055
info:cnr-pdr/source/autori:Milani M.; Donalisio M.; Bonotto R.M.; Schneider E.; Arduino I.; Boni F.; Lembo D.; Marcello A.; Mastrangelo E./titolo:Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 inhibitors/doi:10.1016%2Fj.antiviral.2021.105055/rivista:Antiviral research (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:189
Antiviral Research
189 (2021). doi:10.1016/j.antiviral.2021.105055
info:cnr-pdr/source/autori:Milani M.; Donalisio M.; Bonotto R.M.; Schneider E.; Arduino I.; Boni F.; Lembo D.; Marcello A.; Mastrangelo E./titolo:Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 inhibitors/doi:10.1016%2Fj.antiviral.2021.105055/rivista:Antiviral research (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:189
Antiviral Research
The current emergency of the novel coronavirus SARS-CoV2 urged the need for broad-spectrum antiviral drugs as the first line of treatment. Coronaviruses are a large family of viruses that already challenged humanity in at least two other previous out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b21def4833834663baa0ed52a5acc5c
https://hdl.handle.net/2318/1815508
https://hdl.handle.net/2318/1815508
Autor:
Rafaela Milan Bonotto, Alessandro Marcello, David Lembo, Mario Milani, Eloise Mastrangelo, Manuela Donalisio, Edoardo Schneider, Irene Arduino, Francesco Bonì
The current emergency of the novel coronavirus SARS-CoV-2 urged the need for broad-spectrum antiviral drugs as the first line of treatment. Coronaviruses are a large family of viruses that already challenged humanity in at least two other previous ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf89ddb4302803c1438ba61c313e05af
https://doi.org/10.1101/2020.11.12.379958
https://doi.org/10.1101/2020.11.12.379958
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1867(10)
Guanylate cyclase activating protein 1 (GCAP1) is a neuronal calcium sensor (NCS) involved in the early biochemical steps underlying the phototransduction cascade. By switching from a Ca
Publikováno v:
Biochimica et biophysica acta. Molecular cell research 1867 (2020). doi:10.1016/j.bbamcr.2020.118794
info:cnr-pdr/source/autori:Dal Cortivo G.; Marino V.; Boni F.; Milani M.; Dell'Orco D./titolo:Missense mutations affecting Ca2+-coordination in GCAP1 lead to cone-rod dystrophies by altering protein structural and functional properties/doi:10.1016%2Fj.bbamcr.2020.118794/rivista:Biochimica et biophysica acta. Molecular cell research/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:1867
info:cnr-pdr/source/autori:Dal Cortivo G.; Marino V.; Boni F.; Milani M.; Dell'Orco D./titolo:Missense mutations affecting Ca2+-coordination in GCAP1 lead to cone-rod dystrophies by altering protein structural and functional properties/doi:10.1016%2Fj.bbamcr.2020.118794/rivista:Biochimica et biophysica acta. Molecular cell research/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:1867
Guanylate cyclase activating protein 1 (GCAP1) is a neuronal calcium sensor (NCS) involved in the early biochemical steps underlying the phototransduction cascade. By switching from a Ca2+-bound form in the dark to a Mg2+-bound state following light
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee87c86662936766922d6dc398048ea
http://hdl.handle.net/11562/1021780
http://hdl.handle.net/11562/1021780