Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Francesco Boccalatte"'
Autor:
Alexander Calderon, Tamara Mestvirishvili, Francesco Boccalatte, Kelly V. Ruggles, Gregory David
Publikováno v:
Epigenetics & Chromatin, Vol 17, Iss 1, Pp 1-18 (2024)
Abstract Background Blood homeostasis requires the daily production of millions of terminally differentiated effector cells that all originate from hematopoietic stem cells (HSCs). HSCs are rare and exhibit unique self-renewal and multipotent propert
Externí odkaz:
https://doaj.org/article/8515337339434df2b9638b0d93aa5cfe
Autor:
Lana Bach-Morrow, Francesco Boccalatte, Antonio DeRosa, David Devos, Carmen Garcia-Sanchez, Matilde Inglese, Amgad Droby
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Numerous studies indicate a significant role of pre-frontal circuits (PFC) connectivity involving attentional and reward neural networks within attention deficit hyperactivity disorder (ADHD) pathophysiology. To date, the neural mechanisms u
Externí odkaz:
https://doaj.org/article/437ad554328d4c0494ca47083b430ad4
Autor:
Ludovic Boytard, Tarik Hadi, Michele Silvestro, Hengdong Qu, Andrew Kumpfbeck, Rayan Sleiman, Kissinger Hyppolite Fils, Dornazsadat Alebrahim, Francesco Boccalatte, Matthias Kugler, Annanina Corsica, Bruce E. Gelb, Glenn Jacobowitz, George Miller, Chiara Bellini, Jessica Oakes, Jean-Sébastien Silvestre, Lior Zangi, Bhama Ramkhelawon
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Lung damage increases abdominal aortic aneurysm (AAA) incidence, but the mechanism was unclear. Here, the authors show that injured lungs leak HMGB1, increasing RIPK3 expression in arterial macrophages that subsequently alters mitochondrial function,
Externí odkaz:
https://doaj.org/article/0e153e3e2c704d8d91ffd8a89322f6f4
Autor:
Francesco Boccalatte, Roberto Mina, Andrea Aroldi, Sarah Leone, Carter M. Suryadevara, Dimitris G. Placantonakis, Benedetto Bruno
Publikováno v:
Cancers, Vol 14, Iss 20, p 5108 (2022)
Chimeric antigen receptor (CAR) T cells in solid tumors have so far yielded limited results, in terms of therapeutic effects, as compared to the dramatic results observed for hematological malignancies. Many factors involve both the tumor cells and t
Externí odkaz:
https://doaj.org/article/31f2cf3af5b6415f93da2776d1c7dd7f
Autor:
Roberto Chiarle, Giorgio Inghirami, Giorgio Palestro, Ole N. Jensen, Shabaz Mohammed, Francesco Boccalatte, Elisabetta Boeri Erba, Chiara Ambrogio, Chiara Conte, Claudia Voena
Supplementary Figure 1 from The Tyrosine Phosphatase Shp2 Interacts with NPM-ALK and Regulates Anaplastic Lymphoma Cell Growth and Migration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400dc36247b8522406846478e9148a25
https://doi.org/10.1158/0008-5472.22371488.v1
https://doi.org/10.1158/0008-5472.22371488.v1
Autor:
Roberto Chiarle, Giorgio Inghirami, Giorgio Palestro, Ole N. Jensen, Shabaz Mohammed, Francesco Boccalatte, Elisabetta Boeri Erba, Chiara Ambrogio, Chiara Conte, Claudia Voena
Anaplastic large cell lymphomas (ALCL) are mainly characterized by the reciprocal translocation t(2;5)(p23;q35) that involves the anaplastic lymphoma kinase (ALK) gene and generates the fusion protein NPM-ALK with intrinsic tyrosine kinase activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a213b4ea3a6f2e8302b7ce67044a4b24
https://doi.org/10.1158/0008-5472.c.6496823
https://doi.org/10.1158/0008-5472.c.6496823
Autor:
Alexander Calderon, Tamara Mestvirishvili, Francesco Boccalatte, Kelly V. Ruggles, Gregory David
Publikováno v:
bioRxiv
/SummaryTo maintain blood homeostasis, millions of terminally differentiated effector cells are produced every day. At the apex of this massive and constant blood production lie hematopoietic stem cells (HSCs), a rare cell type harboring unique self-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16e97d9ffd4107e2f220811a23c5554
https://doi.org/10.1101/2023.01.23.525185
https://doi.org/10.1101/2023.01.23.525185
Autor:
Jimin Tan, Nina Shenker-Tauris, Javier Rodriguez-Hernaez, Eric Wang, Theodore Sakellaropoulos, Francesco Boccalatte, Palaniraja Thandapani, Jane Skok, Iannis Aifantis, David Fenyö, Bo Xia, Aristotelis Tsirigos
Publikováno v:
Nature Biotechnology.
Investigating how chromatin organization determines cell-type-specific gene expression remains challenging. Experimental methods for measuring three-dimensional chromatin organization, such as Hi-C, are costly and have technical limitations, restrict
Autor:
Maria Parlani, Francesco Boccalatte, Anna Yeaton, Feng Wang, Jianhua Zhang, Iannis Aifantis, Eleonora Dondossola
Publikováno v:
J Nucl Med
(223)Ra is a bone-seeking, α-particle–emitting radionuclide approved for the treatment of patients with metastatic prostate cancer and is currently being tested in a variety of clinical trials for primary and metastatic cancers to bone. Clinical e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18328cce0c1ae246652f6f40f0ae9dd7
https://europepmc.org/articles/PMC9536707/
https://europepmc.org/articles/PMC9536707/
Autor:
Luca Vincenzo Cappelli, Danilo Fiore, Jude M. Phillip, Liron Yoffe, Filomena Di Giacomo, William Chiu, Yang Hu, Clarisse Kayembe, Michael Ginsberg, Lorena Consolino, Jose Gabriel Barcia Duran, Nahuel Zamponi, Ari M. Melnick, Francesco Boccalatte, Wayne Tam, Olivier Elemento, Sabina Chiaretti, Anna Guarini, Robin Foà, Leandro Cerchietti, Shahin Rafii, Giorgio Inghirami
Publikováno v:
Blood.
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive and often incurable disease. To uncover therapeutic vulnerabilities, we first developed T-ALL patient–derived tumor xenografts (PDXs) and exposed PDX cells to a library of 433 clinical-st