Determinants for α4β2 vs. α3β4 Subtype Selectivity of Pyrrolidine-Based nAChRs Ligands: A Computational Perspective with Focus on Recent cryo-EM Receptor Structures

Autor: Francesco Bavo, Marco Pallavicini, Rebecca Appiani, Cristiano Bolchi

Publikováno v: Molecules, Vol 26, Iss 12, p 3603 (2021)

The selectivity of α4β2 nAChR agonists over the α3β4 nicotinic receptor subtype, predominant in ganglia, primarily conditions their therapeutic range and it is still a complex and challenging issue for medicinal chemists and pharmacologists. Here

Externí odkaz: https://doaj.org/article/92948bab41844f2c9c2aa4b0446d9fe9

From 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624) to Selective Small-Molecule Antagonists of Human α9α10 Nicotinic Receptor by Modifications at the Ammonium Ethyl Residue

Autor: Francesco Bavo, Marco Pallavicini, Susanna Pucci, Rebecca Appiani, Alessandro Giraudo, Brek Eaton, Linda Lucero, Cecilia Gotti, Milena Moretti, Paul Whiteaker, Cristiano Bolchi

Publikováno v: Bavo, F, Pallavicini, M, Pucci, S, Appiani, R, Giraudo, A, Eaton, B, Lucero, L, Gotti, C, Moretti, M, Whiteaker, P & Bolchi, C 2022, ' From 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624) to Selective Small-Molecule Antagonists of Human α9α10 Nicotinic Receptor by Modifications at the Ammonium Ethyl Residue ', Journal of Medicinal Chemistry, vol. 65, no. 14, pp. 10079-10097 . https://doi.org/10.1021/acs.jmedchem.2c00746

Nicotinic acetylcholine receptors containing α9 subunits (α9*-nAChRs) are potential druggable targets arousing great interest for pain treatment alternative to opioids. Nonpeptidic small molecules selectively acting as α9*-nAChRs antagonists still

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd6ad38d76bc9fea125d38149cbb80c
https://curis.ku.dk/portal/da/publications/from-2triethylammonium-ethyl-ether-of-4stilbenol-mg624-to-selective-smallmolecule-antagonists-of-human-910-nicotinic-receptor-by-modifications-at-the-ammonium-ethyl-residue(0a208a35-2a1c-4134-86c9-ece88c9bf045).html

Efficient One-Pot Reductive Aminations of Carbonyl Compounds with Aquivion-Fe as a Recyclable Catalyst and Sodium Borohydride

Autor: Riccardo Tassini, Marco Pallavicini, Oreste Piccolo, Veronica Airoldi, Sebastiano Arnoldi, Gabriella Roda, Stefano Paganelli, Cristiano Bolchi, Francesco Bavo, Rebecca Appiani

Publikováno v: European Journal of Organic Chemistry. 2020:162-168

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b542c1b1600e089813e37862c1f16f01
https://doi.org/10.1002/ejoc.201901614

Determinants for α4β2 vs. α3β4 subtype selectivity of pyrrolidine-based nachrs ligands:A computational perspective with focus on recent cryo-em receptor structures

Autor: Francesco Bavo, Marco Pallavicini, Cristiano Bolchi, Rebecca Appiani

Publikováno v: Bavo, F, Pallavicini, M, Appiani, R & Bolchi, C 2021, ' Determinants for α4β2 vs. α3β4 subtype selectivity of pyrrolidine-based nachrs ligands : A computational perspective with focus on recent cryo-em receptor structures ', Molecules, vol. 26, no. 12, 3603 . https://doi.org/10.3390/molecules26123603
Molecules
Molecules, Vol 26, Iss 3603, p 3603 (2021)
Volume 26
Issue 12

The selectivity of α4β2 nAChR agonists over the α3β4 nicotinic receptor subtype, predominant in ganglia, primarily conditions their therapeutic range and it is still a complex and challenging issue for medicinal chemists and pharmacologists. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512c7f5ba85f13f25e44ad6f04bd9fa1
https://curis.ku.dk/ws/files/285447571/molecules_26_03603_v2.pdf

Behavioural and pharmacological profiles of zebrafish administrated pyrrolidinyl benzodioxanes and prolinol aryl ethers with high affinity for heteromeric nicotinic acetylcholine receptors

Autor: Francesco Bavo, Marco Pallavicini, Luisa Ponzoni, Milena Moretti, Paola Viani, Rebecca Appiani, Mariaelvina Sala, Daniela Braida, Cristiano Bolchi, Cecilia Gotti

Publikováno v: Psychopharmacology. 237(8)

Prolinol aryl ethers and their rigidified analogues pyrrolidinyl benzodioxanes have a high affinity for mammalian α4β2 nicotinic acetylcholine receptors (nAChRs). Electrophysiological studies have shown that the former are full agonists and the lat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728a7f1ab77b6ec956ac92bd491fc499
https://pubmed.ncbi.nlm.nih.gov/32382782