Modeling Brain Tumors: A Perspective Overview of in vivo and Organoid Models

Autor: Francesco Antonica, Giuseppe Aiello, Alessia Soldano, Luana Abballe, Evelina Miele, Luca Tiberi

Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2022)

Brain tumors are a large and heterogeneous group of neoplasms that affect the central nervous system and include some of the deadliest cancers. Almost all the conventional and new treatments fail to hinder tumoral growth of the most malignant brain t

Externí odkaz: https://doaj.org/article/d212cfface8d4363a9fafa5fb7aeb36c

Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus and Drosophila melanogaster

Autor: Giuseppe Aiello, Cosimo Sabino, Davide Pernici, Matteo Audano, Francesco Antonica, Matteo Gianesello, Claudio Ballabio, Alessandro Quattrone, Nico Mitro, Alessandro Romanel, Alessia Soldano, Luca Tiberi

Publikováno v: EMBO reports

Lifespan is determined by complex and tangled mechanisms that are largely unknown. The early postnatal stage has been proposed to play a role in lifespan, but its contribution is still controversial. Here, we show that a short rapamycin treatment dur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc52407dd50458714a4dcfeff7cfe995
https://hdl.handle.net/2434/945590

MODL-22. Establishment of a novel system to specifically trace and ablate quiescent/slow cycling cells in high-grade glioma

Autor: Francesco Antonica, Lucia Santomaso, Davide Pernici, Linda Petrucci, Giuseppe Aiello, Alessandro Cutarelli, Luciano Conti, Alessandro Romanel, Evelina Miele, Toma Tebaldi, Luca Tiberi

Publikováno v: Neuro-Oncology. 24:i173-i173

Pediatric and adult high-grade gliomas are the most common malignant brain tumors, with poor prognosis due to recurrence and tumor infiltration after surgical removal and chemotherapy. Quiescent/slow cycling stem cells have been proposed to be one of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0305b1846cc91afb9bd9017ced94f43
https://doi.org/10.1093/neuonc/noac079.645

Notch1 switches progenitor competence in inducing medulloblastoma

Autor: Matteo Gianesello, Tingting Zhang, Giuseppe Aiello, Francesca Gianno, Luca Tiberi, Francesco Antonica, Bassem A. Hassan, Felice Giangaspero, Konstantin Okonechnikov, Claudio Ballabio, Chiara Lago, Stefan M. Pfister, Marica Anderle

Publikováno v: Science Advances
Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (26), pp.eabd2781. ⟨10.1126/sciadv.abd2781⟩
Science Advances, 2021, 7 (26), pp.eabd2781. ⟨10.1126/sciadv.abd2781⟩

Notch1 pathway activation is required for group 3 medulloblastoma initiation.
The identity of the cell of origin is a key determinant of cancer subtype, progression, and prognosis. Group 3 medulloblastoma (MB) is a malignant childhood brain canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67f50fb612bcf0113692e78522c247f
https://hal.sorbonne-universite.fr/hal-03272112/document

OS13.3.A Establishment of a novel system to specifically trace and ablate quiescent/slow cycling cells in high-grade glioma

Autor: Francesco Antonica, Luca Tiberi, Evelina Miele, D Pernici, L Santomaso, Giuseppe Aiello

Publikováno v: Neuro-Oncology. 23:ii16-ii16

BACKGROUND High-grade gliomas are the most common malignant brain tumors, with poor prognosis due to recurrence and tumor infiltration after surgical removal and chemotherapy. Quiescent/slow cycling stem cells have been proposed to be one of the main

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1995da86179c98a113dd09705df3afc3
https://doi.org/10.1093/neuonc/noab180.051