Výsledky vyhledávání - "Francesco Andreata"

Akademický článek

Impact of doxorubicin-loaded ferritin nanocages (FerOX) vs. free doxorubicin on T lymphocytes: a translational clinical study on breast cancer patients undergoing neoadjuvant chemotherapy

Autor: Marta Sevieri, Francesco Andreata, Francesco Mainini, Lorena Signati, Francesca Piccotti, Marta Truffi, Arianna Bonizzi, Leopoldo Sitia, Claudia Pigliacelli, Carlo Morasso, Barbara Tagliaferri, Fabio Corsi, Serena Mazzucchelli

Publikováno v: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-16 (2024)

Abstract Despite the advent of numerous targeted therapies in clinical practice, anthracyclines, including doxorubicin (DOX), continue to play a pivotal role in breast cancer (BC) treatment. DOX directly disrupts DNA replication, demonstrating remark

Externí odkaz: https://doaj.org/article/3c3648d1ce4b4122a7947ebaaeebe0d2

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Akademický článek

CD31 signaling promotes the detachment at the uropod of extravasating neutrophils allowing their migration to sites of inflammation

Autor: Francesco Andreata, Marc Clément, Robert A Benson, Juliette Hadchouel, Emanuele Procopio, Guillaume Even, Julie Vorbe, Samira Benadda, Véronique Ollivier, Benoit Ho-Tin-Noe, Marie Le Borgne, Pasquale Maffia, Antonino Nicoletti, Giuseppina Caligiuri

Publikováno v: eLife, Vol 12 (2023)

Effective neutrophil migration to sites of inflammation is crucial for host immunity. A coordinated cascade of steps allows intravascular leukocytes to counteract the shear stress, transmigrate through the endothelial layer, and move toward the extra

Externí odkaz: https://doaj.org/article/02d59bd211f84887a86d807ad0c9586c

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Akademický článek

Isolation of mouse Kupffer cells for phenotypic and functional studies

Autor: Francesco Andreata, Camille Blériot, Pietro Di Lucia, Giorgia De Simone, Valeria Fumagalli, Xenia Ficht, Cristian Gabriel Beccaria, Mirela Kuka, Florent Ginhoux, Matteo Iannacone

Publikováno v: STAR Protocols, Vol 2, Iss 4, Pp 100831- (2021)

Summary: Here, we provide detailed protocols for the isolation of mouse Kupffer cells – the liver-resident macrophages – for phenotypic (e.g., via flow cytometry, mass cytometry, or RNA-sequencing) analyses or for functional experiments involving

Externí odkaz: https://doaj.org/article/789fccb91ed1475794b87f517ec97729

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Akademický článek

Peptide binding to cleaved CD31 dampens ischemia/reperfusion-induced intestinal injury

Autor: Quoc Thang Hoang, Alexandre Nuzzo, Liliane Louedec, Sandrine Delbosc, Francesco Andreata, Jamila Khallou-Laschet, Maksud Assadi, Philippe Montravers, Dan Longrois, Olivier Corcos, Giuseppina Caligiuri, Antonino Nicoletti, Jean-Baptiste Michel, Alexy Tran-Dinh

Publikováno v: Intensive Care Medicine Experimental, Vol 6, Iss 1, Pp 1-12 (2018)

Abstract Background CD31 is a key transmembrane neutrophil immunoregulatory receptor. Mesenteric ischemia/reperfusion-induced neutrophil activation leads to a massive cleavage and shedding of the most extracellular domains of CD31 into plasma, enhanc

Externí odkaz: https://doaj.org/article/9b470e7f55a44dce921d2439763b1403

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Akademický článek

Inflammatory micro-environmental cues of human atherothrombotic arteries confer to vascular smooth muscle cells the capacity to trigger lymphoid neogenesis.

Autor: Kevin Guedj, Jamila Khallou-Laschet, Marc Clement, Marion Morvan, Sandrine Delbosc, Anh-Thu Gaston, Francesco Andreata, Yves Castier, Catherine Deschildre, Jean-Baptiste Michel, Giuseppina Caligiuri, Antonino Nicoletti

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e116295 (2014)

BACKGROUND: Experimental atherosclerosis is characterized by the formation of tertiary lymphoid structures (TLOs) within the adventitial layer, which involves the chemokine-expressing aortic smooth muscle cells (SMCs). TLOs have also been described a

Externí odkaz: https://doaj.org/article/561a6269781248b18a7b35f09948bd23

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Abstract P4-07-18: FerOX, an anthracyclines nanoformulation to lead toward immuno-mediated cancer remission, preserving T-cell immune competence

Autor: Serena Mazzucchelli, Francesco Mainini, Francesco Andreata, Marta Truffi, Arianna Bonizzi, Francesca Piccotti, Marta Sevieri, Fabio Corsi

Publikováno v: Cancer Research. 83:P4-07

Background Chemotherapy with anthracyclines, such as doxorubicin (DOX), still remains a mainstay in cancer treatment. DOX kills tumor cells by direct interference with DNA replication, thus it is very effective against highly proliferating cells. Sin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7598576291ab939f9623af798e791aa9
https://doi.org/10.1158/1538-7445.sabcs22-p4-07-18

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Group 1 ILCs regulate T cell–mediated liver immunopathology by controlling local IL-2 availability

Publikováno v: Science Immunology
Science Immunology, 2022, 7 (68), ⟨10.1126/sciimmunol.abi6112⟩

Group 1 innate lymphoid cells (ILCs), which comprise both natural killer (NK) cells and ILC1s, are important innate effectors that can also positively and negatively influence adaptive immune responses. The latter function is generally ascribed to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5261369bdcd09e7fd92e474c3b145bf
https://doi.org/10.1126/sciimmunol.abi6112

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