Data from Sonic Hedgehog and Gli1 Expression Predict Outcome in Resected Pancreatic Adenocarcinoma

Autor: Jean-Luc Van Laethem, Jean-François Emile, Jacques Devière, Isabelle Salmon, Thierry André, Alain Sauvanet, Jean-Christophe Vaillant, Yves Patrice Le Treut, Philippe Bachelier, François Paye, Christophe Louvet, Pascal Hammel, Geneviève Monges, Francesco Puleo, Armelle Bardier-Dupas, Jérôme Cros, Magali Svrcek, Jean Robert Delpero, Pieter Demetter, Annabelle Calomme, Jean-Baptiste Bachet, Raphaël Maréchal

Purpose: Aberrant activation of the hedgehog (Hh) pathway is implicated in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis. We investigated the prognostic and predictive value of four Hh signaling proteins and of the tumor stromal density.Exper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fdfb1d212990439482c94c3badc4f7d
https://doi.org/10.1158/1078-0432.c.6524651.v1

Pancreatic Ductal Adenocarcinoma Arising in Young and Old Patients Displays Similar Molecular Features

Autor: Jean-François Emile, Jean-Luc Van Laethem, Jérôme Torrisani, Pieter Demetter, Yuna Blum, Anne Couvelard, Pascal Hammel, Armelle Bardier-Dupas, Francesco Puleo, Miroslaw Radman, Jérôme Cros, Magali Svrcek, Rémy Nicolle, Jerome Raffenne, Valérie Paradis, Fernando Ariel Martin, Marina Konta, Jean-Baptiste Bachet, Vinciane Rebours

Publikováno v: Cancers
Volume 13
Issue 6
Cancers, MDPI, 2021, 13 (6), pp.1234. ⟨10.3390/cancers13061234⟩
Cancers, Vol 13, Iss 1234, p 1234 (2021)
Cancers (Basel), 13 (6
Cancers, 2021, 13 (6), pp.1234. ⟨10.3390/cancers13061234⟩

Pancreatic ducal adenocarcinoma is classically diagnosed in the 7th decade, but approximately 10% of patients are diagnosed under 55 years (y.o.). While the genomic and transcriptomic landscapes of late‐onset tumors (LOT) have been described, littl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95462195a0326b20b6cde864d253619e

Undifferentiated Pancreatic Carcinoma With Osteoclast-Like Giant Cells: What Do We Know So Far?

Autor: Jean-Luc Van Laethem, Laurine Verset, Myriam Delhaye, Pieter Demetter, Francesco Puleo, Sebastien Debroux, Raphaël Maréchal, Fadi Charara, Maria Gomez Galdon

Publikováno v: Frontiers in Oncology
Frontiers in Oncology, Vol 11 (2021)
Frontiers in oncology, 11

Undifferentiated carcinoma of the pancreas is an aggressive but rare tumor for which several other terms have been used to describe its histological appearance. In addition, as osteoclast-like giant cells may accompany undifferentiated carcinoma of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac26682a9f2b26e1076be3f0399ab95
http://europepmc.org/articles/PMC7973287

PDAC Arising in Young and Old Patients Display Similar Molecular Features

Autor: Jean-François Emile, Jean-Luc Van Laethem, Magali Svrcek, Francesco Puleo, Pascal Hammel, Jean-Baptiste Bachet, Miroslav Radman, Yuna Blum, Valérie Paradis, Anne Couvelard, Jérôme Cros, Jérôme Torrisani, Marina Konta, Fernando Ariel Martin, Armel Bardier-Dupas, Vinciane Rebours, P. Demetter, Rémy Nicolle, Jerome Raffenne

Publikováno v: SSRN Electronic Journal.

Pancreatic ducal adenocarcinoma is classically diagnosed in the 7th decade. Yet, approximately 10% of patients are diagnosed under 55 years. While the genomic and transcriptomic landscapes of late onset tumors (LOT) have been described, little is kno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::710a8cbfae2390bf286d200ac02712cd
https://doi.org/10.2139/ssrn.3692419

Circulating tumor DNA in early response assessment and monitoring of advanced colorectal cancer treated with a multikinase inhibitor

Autor: Caroline Vandeputte, Pierre Heimann, Christine Desmedt, Francesco Puleo, Gauthier Demolin, Patrick Flamen, Javier Carrasco, Christos Sotiriou, Lieveke Ameye, Thierry Delaunoit, Lionel D'Hondt, Marc Peeters, Jos Janssens, Marianne Paesmans, Jean-François Laes, Pashalina Kehagias, Amélie Deleporte, Raphaël Maréchal, Maria Gomez Galdon, Alain Hendlisz, Hakim El Housni, Karen Geboes

Publikováno v: Oncotarget, 9 (25
Oncotarget
ONCOTARGET

Predictive biomarkers are eagerly awaited in advanced colorectal cancer (aCRC). Targeted sequencing performed on tumor and baseline plasma samples in 20 patients with aCRC treated with regorafenib identified 89 tumor-specific mutations of which ≥50

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6ab8c0b1d4e149248429fd26437a39
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/270532