Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Francesco Bondavalli"'
Autor:
Christian Roussel, Francesco Bondavalli, Olga Bruno, Silvia Schenone, Andrea Spallarossa, Nicolas Vanthuyne, Alessia Romussi, Chiara Brullo
Publikováno v:
Journal of Medicinal Chemistry. 52:6546-6557
The lack of selective inhibitors toward the long, short, or supershort phosphodiesterases (PDE4s) prevented researchers from carefully defining the connection between different enzyme isoforms, their brain localization, and their role in neurodegener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c11ae74766c4db3452fb4c2f0de08a3
https://doi.org/10.1021/jm900977c
https://doi.org/10.1021/jm900977c
Autor:
Emmanuele Crespan, Chiara Brullo, Giovanni Maga, M Magnani, Maria Letizia Trincavelli, Silvia Schenone, Francesco Bondavalli, Antonella Naldini, Claudia Martini, Fabrizio Manetti, Fabio Carraro, Maurizio Botta, Francesca Mosci, Beatrice Chelli, Olga Bruno
Publikováno v:
Journal of Medicinal Chemistry. 51:1252-1259
Results from molecular docking calculations and Grid mapping laid the foundations for a structure-based optimization approach to improve the biological properties of pyrazolo-pyrimidine derivatives in terms of inhibition of Abl enzymatic activity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1bc89fa34a63701efe572e3cb446e8
https://doi.org/10.1021/jm701240c
https://doi.org/10.1021/jm701240c
Publikováno v:
Current Medicinal Chemistry. 14:2495-2516
Angiogenesis is a tightly regulated process that leads to the formation of new blood vessels sprouting from pre-existing microvasculature and occurs in limited physiological conditions or under pathological situations such as retinopathies, arthritis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291fa04350dea3fdcb504883f64ff148
https://doi.org/10.2174/092986707782023622
https://doi.org/10.2174/092986707782023622
Autor:
Francesco Bondavalli, Olga Bruno, Simona Bertoni, Fabrizio Montecucco, Nicoletta Arduino, Maria B. Bertolotto, C. Brullo, L. Ottonello, Angelo Ranise, Vigilio Ballabeni, Franco Dallegri, Massimiliano Tognolini, Elisabetta Barocelli, Silvia Schenone
Publikováno v:
Journal of Medicinal Chemistry. 50:3618-3626
Neutrophils chemotaxis is a complex multistep process that, if upregulated, causes acute inflammation and a number of autoimmune diseases. We report here the synthesis of a new N-(4-substituted)pyrazolyl-N'-alkyl/benzyl/phenylureas that are potent in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33465876c2c1ec65a3b546abbe0ba60e
https://doi.org/10.1021/jm0704402
https://doi.org/10.1021/jm0704402
Autor:
Angelo Ranise, Francesco Bondavalli, Chiara Casolino, Silvia Schenone, Luisa Mosti, Michele Forina, Paola Fossa
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:1348-1363
In this paper, we are presenting a quantitative-structure–activity relationship (QSAR) study performed on 21 selective A 1 adenosine receptor agonists plus the endogenous substrate, adenosine, so as to identify those predictors which play a key rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82ba1d9e8126802c63547c1c08d796e
https://doi.org/10.1016/j.bmc.2005.09.058
https://doi.org/10.1016/j.bmc.2005.09.058
Autor:
Silvia Schenone, Paola Fossa, Maurizio Botta, Marina Ziche, Giulia Menozzi, Luisa Mosti, Fabrizio Manetti, Francesco Bondavalli, Olga Bruno, Annalisa Santoro, Angelo Ranise, Sandra Donnini
Publikováno v:
European Journal of Medicinal Chemistry. 39:939-946
Synthesis and biological evaluation of a new class of 1-aryl-4-amino-1H-pyrazolo[3,4-d]pyrimidine derivatives are reported. A preliminary cellular assay system using the tumor cell line A431 responding to epidermal growth factor (EGF) for its growth,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5dcb42fe32f1ce6c86cf8fc55aa13b
https://doi.org/10.1016/j.ejmech.2004.07.010
https://doi.org/10.1016/j.ejmech.2004.07.010
Autor:
Olga Bruno, Luciano Ottonello, Francesco Bondavalli, Silvia Schenone, Chiara Brullo, Nicoletta Arduino, Franco Dallegri, Angelo Ranise, Patrizia Dapino
Publikováno v:
Il Farmaco. 59:223-235
In several non-infectious human diseases, such as ulcerous colitis, rheumatoid arthritis, chronic obstructive pulmonary disease (COPD), the extravasal recruitment of neutrophils plays a crucial role in the development of tissue damage, which, when pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76756a7e8f7d8172718f756f940e752e
https://doi.org/10.1016/j.farmac.2003.08.005
https://doi.org/10.1016/j.farmac.2003.08.005
Autor:
Tiziana Marceddu, Paolo La Colla, Alessandra Pani, O. Bruno, Silvia Schenone, Francesco Bondavalli, Andrea Spallarossa, Angelo Ranise, Massimo Mura, Laura Vargiu
Publikováno v:
Journal of Medicinal Chemistry. 46:768-781
A novel series of potent, selective HIV-1 N-acylthiocarbamate (ATC) nonnucleoside reverse transcriptase inhibitors (NNRTIs) is described. The title compounds were synthesized through a highly convergent, one-pot procedure. In cell-based assays, the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ea4de4db6b9670b1fcefc5bb11f1cc
https://doi.org/10.1021/jm0209984
https://doi.org/10.1021/jm0209984
Autor:
Angelo Ranise, Luisa Mosti, Fabrizio Giordanetto, Francesco Bondavalli, Giulia Menozzi, Silvia Schenone, Paola Fossa
Publikováno v:
Journal of Computer-Aided Molecular Design. 17:39-51
Adenosine is a naturally occurring purine nucleoside that has a wide variety of well-documented regulatory functions and physiological roles. Selective activation of the adenosine A1 receptor has drawn attention in drug discovery for the therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c1bdfb635fa806e5de1e1914ace8074
https://doi.org/10.1023/a:1024530029922
https://doi.org/10.1023/a:1024530029922
Autor:
Angelo Ranise, Barbara Rivaldi, Olga Bruno, Francesco Bondavalli, Giuseppe Falcone, Silvia Schenone, Walter Filippelli
Publikováno v:
Il Farmaco. 56:647-657
Six series of N -acyl- N -phenyl ureas 1 – 6 of piperidine ( 1 ), and 2-ethyl- ( 2 ), 3-methyl- ( 3 ), 4-methyl- ( 4 ), 4-phenyl- ( 5 ), cis -2,6-dimethyl- ( 6 ) piperidine were synthesised and evaluated for their anti-inflammatory, anaesthetic, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269bdeeaaca5cea1862e9d7cb081f0d7
https://doi.org/10.1016/s0014-827x(01)01120-x
https://doi.org/10.1016/s0014-827x(01)01120-x