Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Francesco, Pinnen"'
Autor:
Ivana Cacciatore, Erika Fornasari, Leonardo Baldassarre, Catia Cornacchia, Stefania Fulle, Ester Sara Di Filippo, Tiziana Pietrangelo, Francesco Pinnen
Publikováno v:
Pharmaceuticals, Vol 6, Iss 1, Pp 54-69 (2013)
A novel bis-lipoyl derivative containing 8-hydroxyquinoline scaffold (LA-HQ-LA, 5) was synthesized as a new multifunctional drug candidate with antioxidant, chelant, and neuroprotective properties for the treatment of neurodegenerative diseases. We h
Externí odkaz:
https://doaj.org/article/fa38ca9b2812463a8dd6b0e79578978c
Publikováno v:
Molecules, Vol 17, Iss 5, Pp 6083-6099 (2012)
Marine sponges. (e.g., Hyrtios sp., Dragmacidin sp., Aglophenia pleuma, Aplidium cyaneum, Aplidium meridianum.) produce bioactive secondary metabolites involved in their defence mechanisms. Recently it was demonstrated that several of those compounds
Externí odkaz:
https://doaj.org/article/e6e4633f483e40ad9a189f72730f1ea2
Publikováno v:
Molecules, Vol 15, Iss 3, Pp 1242-1264 (2010)
Reduced glutathione (GSH) is the most abundant non-protein thiol in mammalian cells and the preferred substrate for several enzymes in xenobiotic metabolism and antioxidant defense. It plays an important role in many cellular processes, such as cell
Externí odkaz:
https://doaj.org/article/2ee08ae7859441969855bd600e5ccfb0
Autor:
Antonio Limatola, Frank Porreca, Azzurra Stefanucci, Alfonso Carotenuto, Reza Samavati, Ferenc Zádor, Sándor Benyhe, Ettore Novellino, Adriano Mollica, Roberto Costante, Victor J. Hruby, Peg Davis, Francesco Pinnen, Stefano Pieretti, Anna Borsodi
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1032-1036
Two novel opioid analogues have been designed by substituting the native d-Ala residues in position 2,2' of biphalin with two residues of d-penicillamine or l-penicillamine and by forming a disulfide bond between the thiol groups. The so-obtained com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9ab15d472ff81d7687276c7b09d490
https://doi.org/10.1021/ml500241n
https://doi.org/10.1021/ml500241n
Autor:
Grazia Luisi, Adriano Mollica, Azzurra Stefanucci, Engin Bojnik, Sándor Benyhe, Roberto Costante, Francesco Pinnen, Anna Borsodi, Stefano Pieretti
Publikováno v:
European Journal of Medicinal Chemistry. 68:167-177
Endomorphin-2 [Tyr-Pro-Phe-Phe-NH2] and DAMGO [Tyr-D-Ala-Gly-(N-Me)Phe-Gly-ol] are natural (EM2) and synthetic (DAMGO) opioid peptides both selective for μ opioid receptor with high analgesic activity. In this work we report synthesis, in vitro and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3aa53607ce6dddf9127a61d46474046
https://doi.org/10.1016/j.ejmech.2013.07.044
https://doi.org/10.1016/j.ejmech.2013.07.044
Autor:
Ivana Cacciatore, Ester Sara Di Filippo, Piera Sozio, Antonio Di Stefano, Erika Fornasari, Catia Cornacchia, Stefania Fulle, Alessio Ferrone, Francesco Pinnen, Rita La Rovere, Lisa Marinelli, Annalisa Dean, Valerio Di Marco, Antonia Patruno, Leonardo Baldassarre
Publikováno v:
ChemMedChem. 8:1818-1829
Metal-ion dysregulation and oxidative stress have been linked to the progressive neurological decline associated with neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Herein we report the synthesis and chelating, antioxidant,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f7f87b8c4fdd82a806ea2131d97d85
https://doi.org/10.1002/cmdc.201300295
https://doi.org/10.1002/cmdc.201300295
Publikováno v:
Protein & Peptide Letters. 19:1245-1249
A new synthetic pathway is described to prepare asymmetrically protected 2,7-diaminosuberic acid. This strategy exploits (acyloxy)alkoxy promoiety as protecting group and RCM reaction using second generation Grubbs catalyst and provides the trans iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365d8c0637ec0bf499120ee16b698339
https://doi.org/10.2174/092986612803521666
https://doi.org/10.2174/092986612803521666
Autor:
Ivana Cacciatore, Erika Fornasari, Leonardo Baldassarre, Luigina Cellini, Francesco Pinnen, Catia Cornacchia, M. Baffoni
Publikováno v:
Journal of Peptide Science. 18:567-578
Worldwide efforts are underway to develop new antimicrobial agents against bacterial resistance. To identify new compounds with a good antimicrobial profile, we designed and synthesized two series of small cationic antimicrobial peptidomimetics (1–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d95f9d9017a518614d8552912244136d
https://doi.org/10.1002/psc.2435
https://doi.org/10.1002/psc.2435
Autor:
Antonio Di Stefano, Adriano Mollica, Ivana Cacciatore, Laura Serafina Cerasa, Cinzia Nasuti, Catia Cornacchia, Piera Sozio, Francesco Pinnen, Antonio Iannitelli, Antonella Fontana
Publikováno v:
Amino Acids. 42:261-269
Parkinson's disease (PD) is a neurodegenerative disorder associated primarily with loss of dopamine (DA) neurons in the nigrostriatal system. With the aim of increasing the bioavailability of L: -dopa (LD) after oral administration and of overcoming
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7604c285e440fca24accf2d6ec2a47cd
https://doi.org/10.1007/s00726-010-0804-z
https://doi.org/10.1007/s00726-010-0804-z
Autor:
Ivana Cacciatore, Carmela Conte, Elena Taha, Francesco Pinnen, Catia Cornacchia, Alba Minelli, Elvira Prudenzi
Publikováno v:
Free Radical Biology and Medicine. 49:31-39
Initiation and progression of Parkinson's disease seem to be linked to oxidative stress, closely related to decreased mitochondrial functions and ubiquitin proteasome system dysfunction. To date, L-Dopa is the most effective medication , although lon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26cd3499adee45809983597b12f5b6cb
https://doi.org/10.1016/j.freeradbiomed.2010.03.011
https://doi.org/10.1016/j.freeradbiomed.2010.03.011