Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Francesco, Lotti"'
Autor:
Irina Utkina-Sosunova, Alessia Chiorazzi, Mariangels de Planell-Saguer, Hai Li, Cristina Meregalli, Eleonora Pozzi, Valentina Alda Carozzi, Annalisa Canta, Laura Monza, Paola Alberti, Giulia Fumagalli, Charles Karan, Yalda Moayedi, Serge Przedborski, Guido Cavaletti, Francesco Lotti
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Peripheral neurotoxicity is a dose-limiting adverse reaction of primary frontline chemotherapeutic agents, including vincristine. Neuropathy can be so disabling that patients drop out of potentially curative therapy, negatively impacting can
Externí odkaz:
https://doaj.org/article/becfb928778f4455b47dda2d76d7e062
Autor:
Nicola Mondaini, Mauro Gacci, Tommaso Cai, Francesco Lotti, Vincenzo Li Marzi, Fabio Crocerossa, Francesco Cantiello, Sara Tanguenza, Alessandra Comito, Irene Fusco, Beatrice Pennati, Rocco Damiano
Publikováno v:
Archivio Italiano di Urologia e Andrologia, Vol 96, Iss 3 (2024)
Background: The increased hypertonicity or activity of pelvic floor muscles can lead to chronic pelvic pain (CPP). It represents an aspecific and persistent pain with no apparent clinical reason, affecting an estimated 6% to 16% of women worldwide. T
Externí odkaz:
https://doaj.org/article/baf677ed348541e0b65fef88084b6d66
Autor:
Georgia Dermentzaki, Mattia Furlan, Iris Tanaka, Tommaso Leonardi, Paola Rinchetti, Patricia M.S. Passos, Alliny Bastos, Yuna M. Ayala, Jacob H. Hanna, Serge Przedborski, Dario Bonanomi, Mattia Pelizzola, Francesco Lotti
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113999- (2024)
Summary: Motor neuron (MN) demise is a hallmark of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Post-transcriptional gene regulation can control RNA’s fate, and defects in RNA processing are critical determinan
Externí odkaz:
https://doaj.org/article/464ceed631b845cfb653dd5c230fb38a
Autor:
Letizia Canu, Clotilde Sparano, Lara Naletto, Giuseppina De Filpo, Giulia Cantini, Elena Rapizzi, Serena Martinelli, Tonino Ercolino, Francesca Cioppi, Alessandro Fantoni, Lorenzo Zanatta, Alessandro Terreni, Massimo Mannelli, Michaela Luconi, Mario Maggi, Francesco Lotti
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2024)
PurposeAdrenocortical carcinoma (ACC) is a rare and aggressive tumor. ACC male patients under adjuvant mitotane therapy (AMT) frequently develop hypogonadism, however sexual function has never been assessed in this setting. The aim of this retrospect
Externí odkaz:
https://doaj.org/article/c80ae0ff8c364ee99c9961898ea05a70
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Since its first identification as the gene responsible for spinal muscular atrophy (SMA), the range of survival motor neuron (SMN) protein functions has increasingly expanded. This multimeric complex plays a crucial role in a variety of RNA processin
Externí odkaz:
https://doaj.org/article/2f93bf65535447b3acf7a96e4fe6235e
Autor:
Giulietta M. Riboldi, Irene Faravelli, Takaaki Kuwajima, Nicolas Delestrée, Georgia Dermentzaki, Mariangels De Planell-Saguer, Paola Rinchetti, Le Thi Hao, Christine C. Beattie, Stefania Corti, Serge Przedborski, George Z. Mentis, Francesco Lotti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Sumoylation is important for the assembly and function of the SMN complex, which plays a central role in RNA processing. Here the authors show that loss of this posttranslational modification impairs the ability of SMN to correct selective deficits i
Externí odkaz:
https://doaj.org/article/9ae40bf770e34a49910b6f8f9467d2e2
Autor:
Vartika Mishra, Diane B. Re, Virginia Le Verche, Mariano J. Alvarez, Alessandro Vasciaveo, Arnaud Jacquier, Paschalis-Tomas Doulias, Todd M. Greco, Monica Nizzardo, Dimitra Papadimitriou, Tetsuya Nagata, Paola Rinchetti, Eduardo J. Perez-Torres, Kristin A. Politi, Burcin Ikiz, Kevin Clare, Manuel E. Than, Stefania Corti, Harry Ischiropoulos, Francesco Lotti, Andrea Califano, Serge Przedborski
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Neuron-astrocyte communication plays a key role in pathophysiology, however systematic approaches to unveil it are limited. Here, the authors propose SEARCHIN, a multi-modal integrated workflow, as a tool to identify cross-compartment ligand-receptor
Externí odkaz:
https://doaj.org/article/7681c96b65b048b3a882c2b7968c3864
Autor:
Francesco Lotti, Mario Maggi
Publikováno v:
Andrology. 11:399-416
Diabetes mellitus (DM) is a global epidemic characterized by high morbidity and mortality. DM can lead to acute and chronic systemic complications. Among them, a negative effect of DM on sperm quality and male/couple fertility has been suggested. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5b8e1281c5f859d87064215a13523e
https://doi.org/10.1111/andr.13342
https://doi.org/10.1111/andr.13342
Autor:
Georgia Dermentzaki, Francesco Lotti
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
RNA modifications termed epitranscriptomics represent an additional layer of gene regulation similar to epigenetic mechanisms operating on DNA. The dynamic nature and the increasing number of RNA modifications offer new opportunities for a rapid fine
Externí odkaz:
https://doaj.org/article/2362480f9d0c4f9bacaabcab493de3b3
Autor:
Christian M. Simon, Meaghan Van Alstyne, Francesco Lotti, Elena Bianchetti, Sarah Tisdale, D. Martin Watterson, George Z. Mentis, Livio Pellizzoni
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 3885-3901.e5 (2019)
Summary: Reduced expression of the survival motor neuron (SMN) protein causes the neurodegenerative disease spinal muscular atrophy (SMA). Here, we show that adeno-associated virus serotype 9 (AAV9)-mediated delivery of Stasimon—a gene encoding an
Externí odkaz:
https://doaj.org/article/3ef4df7377d04d358abb9afb44d3914d