Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Francesco, Hofmann"'
Autor:
Kathleen Sprouffske, Grainne Kerr, Cheng Li, Anirudh Prahallad, Ramona Rebmann, Verena Waehle, Ulrike Naumann, Hans Bitter, Michael R Jensen, Francesco Hofmann, Saskia M Brachmann, Stéphane Ferretti, Audrey Kauffmann
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 323-331 (2020)
Genetic heterogeneity within a tumor arises by clonal evolution, and patients with highly heterogeneous tumors are more likely to be resistant to therapy and have reduced survival. Clonal evolution also occurs when a subset of cells leave the primary
Externí odkaz:
https://doaj.org/article/f59eeb0474a14975baefb2770967be51
Autor:
Emilie A Chapeau, Emeline Mandon, Jason Gill, Vincent Romanet, Nicolas Ebel, Violetta Powajbo, Rita Andraos-Rey, Zhiyan Qian, Miltos Kininis, Sabine Zumstein-Mecker, Moriko Ito, Nancy E Hynes, Ralph Tiedt, Francesco Hofmann, Leonid Eshkind, Ernesto Bockamp, Bernd Kinzel, Matthias Mueller, Masato Murakami, Fabienne Baffert, Thomas Radimerski
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0221635 (2019)
Aberrant activation of the JAK/STAT pathway is thought to be the critical event in the pathogenesis of the chronic myeloproliferative neoplasms, polycythemia vera, essential thrombocythemia and primary myelofibrosis. The most frequent genetic alterat
Externí odkaz:
https://doaj.org/article/a9675b428fbc4f1489023b4044ed239c
Autor:
William R. Sellers, Francesco Hofmann, Giorgio Caravatti, Robert Schlegel, Joseph Lehar, Robert Cozens, Marion Wiesmann, Patrick Chene, Carlos Garcia-Echeverria, Markus Boehm, Christopher Wilson, Sauveur-Michel Maira, Saskia M. Brachmann, Joerg Trappe, Youzhen Wang, Stephane Ferretti, Hui Gao, Pascal Furet, Alain De Pover, Dirk Erdmann, Daniel Guthy, Audrey Kauffmann, Manway Liu, Anupama Reddy, Christian Schnell, Christian Chatenay-Rivauday, Alan Huang, Christine Fritsch
PDF - 60K, Linear correlation observed between tumor growth inhibition (% T/C) or tumor regression and the fraction of time over the in vivo S473P-Akt IC80 in different cancer cell line-derived tumor xenografts implanted in nude mice (represented as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46c451963b6c78f1e12fd0af2cb9344
https://doi.org/10.1158/1535-7163.22500847.v1
https://doi.org/10.1158/1535-7163.22500847.v1
Autor:
Charles F. Voliva, William R. Sellers, Carlos García-Echeverría, Francesco Hofmann, Robert Schlegel, Christopher J. Wilson, Doriano Fabbro, Georg Martiny-Baron, Daniel Menezes, Alain De Pover, Kevin Shoemaker, Patrick Chène, Marion Dorsch, Christine Fritsch, Saskia Brachmann, Marion Wiesmann, Tobi Nagel, Daniel Guthy, Christian Schnell, Dario Sterker, Mark Knapp, Matthew Burger, Alan Huang, Sabina Pecchi, Sauveur-Michel Maira
PDF file - 504K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5217e68bb6f66bf8de1b2c62617ded0d
https://doi.org/10.1158/1535-7163.22498663.v1
https://doi.org/10.1158/1535-7163.22498663.v1
Autor:
Ralph Tiedt, Alan Buckler, Christopher J. Wilson, Diana Graus-Porta, Vic E. Myer, Jeffrey A. Porter, William R. Sellers, Francesco Hofmann, Peter M. Finan, Thomas Metz, Vito Guagnano, Chris X. Lu, Feng He, Yao Yao, Christian Chatenay-Rivauday, Andreas Buness, Christelle Stamm, Sabrina Wagner, Kelly Ann Sheppard, Lijuan Liu, Douglas Jeffery, Sneha Sanghavi, Vanessa J. Craig, Fred Harbinski
PDF file - 75K, This file contains detailed descriptions of materials and methods that had to be omitted from the main manuscript due to space limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c98b6b1a6e0d1506dc7ac17ab9bf49
https://doi.org/10.1158/2159-8290.22528515.v1
https://doi.org/10.1158/2159-8290.22528515.v1
Autor:
Chris Jones, Suzanne A. Eccles, Darren Hargrave, Francesco Hofmann, Florence I. Raynaud, Sebastien Jeay, Sharon Gowan, Sergey Popov, Alexa Jury, Vanessa Martins, Alexis de Haven Brandon, Melanie Valenti, Gary M. Box, Lara Perryman, Aleksandra Bielen
Pediatric glioblastoma (pGBM), although rare, is one of the leading causes of cancer-related deaths in children, with tumors essentially refractory to existing treatments. We have identified IGF1R to be a potential therapeutic target in pGBM due to g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::640aae47942f24340443cc8cc3e198f2
https://doi.org/10.1158/1535-7163.c.6535482
https://doi.org/10.1158/1535-7163.c.6535482
Autor:
Chris Jones, Suzanne A. Eccles, Darren Hargrave, Francesco Hofmann, Florence I. Raynaud, Sebastien Jeay, Sharon Gowan, Sergey Popov, Alexa Jury, Vanessa Martins, Alexis de Haven Brandon, Melanie Valenti, Gary M. Box, Lara Perryman, Aleksandra Bielen
Supplementary Figure 3 from Enhanced Efficacy of IGF1R Inhibition in Pediatric Glioblastoma by Combinatorial Targeting of PDGFRα/β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ea1a0d2375245f2f675778fbd807ca
https://doi.org/10.1158/1535-7163.22497045
https://doi.org/10.1158/1535-7163.22497045
Autor:
William R. Sellers, Francesco Hofmann, Giorgio Caravatti, Robert Schlegel, Joseph Lehar, Robert Cozens, Marion Wiesmann, Patrick Chene, Carlos Garcia-Echeverria, Markus Boehm, Christopher Wilson, Sauveur-Michel Maira, Saskia M. Brachmann, Joerg Trappe, Youzhen Wang, Stephane Ferretti, Hui Gao, Pascal Furet, Alain De Pover, Dirk Erdmann, Daniel Guthy, Audrey Kauffmann, Manway Liu, Anupama Reddy, Christian Schnell, Christian Chatenay-Rivauday, Alan Huang, Christine Fritsch
Somatic PIK3CA mutations are frequently found in solid tumors, raising the hypothesis that selective inhibition of PI3Kα may have robust efficacy in PIK3CA-mutant cancers while sparing patients the side-effects associated with broader inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d1880b1b9abb1f6035e8d18e36185fc
https://doi.org/10.1158/1535-7163.c.6536590.v1
https://doi.org/10.1158/1535-7163.c.6536590.v1
Autor:
Sauveur-Michel Maira, Francesco Hofmann, William R. Sellers, Carlos Garcia-Echeverria, Christine Fritsch, Thomas Brümmendorf, Christopher Wilson, Sebastian Bergling, Dario Sterker, Daniel Alexander Guthy, Masato Murakami, Chrystèle Henry, Vincent Romanet, Juliane Vaxelaire, Fabian Stauffer, Marc Hattenberger, Laurent Laborde, Malika Kazic-Legueux, Marcel J.J. Blommers, Audrey Kauffmann, Swann Gaulis, Julia Kleylein-Sohn, Saskia M. Brachmann
PDF file, 300KB, A. Upon infection with viral particles obtained from the pBabe-puro-myr-Akt retroviral vectors, pools were selected upon addition of puromycin and maintained in culture for several weeks. Extracts from pools were generated for the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e85719f22ad670c32e0e20ca95848c4
https://doi.org/10.1158/1535-7163.22497505.v1
https://doi.org/10.1158/1535-7163.22497505.v1
Autor:
Thomas Radimerski, Francesco Hofmann, William R. Sellers, Ross L. Levine, Hans Voshol, Christoph Gaul, Paul W. Manley, Carole Pissot-Soldermann, Fabienne Baffert, Gisele Tavares, Lorenza Wyder, Aviva Goel, Priya Koppikar, Neha Bhagwat, Hugues Ryckelynck, Alain De Pover, Catherine H. Régnier, Fanny Marque, Clemens Scheufler, Eric Vangrevelinghe, Joëlle Rubert, Débora Bonenfant, Zhiyan Qian, Rita Andraos
PDF file - 841K, Supplementary Figures S1-S6; legends for Supplementary Tables S1-S3; Supplementary Methods describing RNA interference, generation of Ba/F3 cell lines, site-directed mutagenesis, transient transfection, inhibition of cellular ATP pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d1c96f82771189e532e391627afa78
https://doi.org/10.1158/2159-8290.22528301.v1
https://doi.org/10.1158/2159-8290.22528301.v1