Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Francesco, De Sanctis"'
Autor:
Chiara Musiu, Francesca Lupo, Antonio Agostini, Gabriella Lionetto, Michele Bevere, Salvatore Paiella, Carmine Carbone, Vincenzo Corbo, Stefano Ugel, Francesco De Sanctis
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Despite the efforts, pancreatic ductal adenocarcinoma (PDAC) is still highly lethal. Therapeutic challenges reside in late diagnosis and establishment of peculiar tumor microenvironment (TME) supporting tumor outgrowth. This stromal landscape is high
Externí odkaz:
https://doaj.org/article/45ea383fc8e649cc854103c3a4f8f1fd
Autor:
Antonio Agostini, Ilaria Guerriero, Geny Piro, Giuseppe Quero, Luca Roberto, Annachiara Esposito, Alessia Caggiano, Lorenzo Priori, Giulia Scaglione, Francesco De Sanctis, Antonella Sistigu, Martina Musella, Alberto Larghi, Gianenrico Rizzatti, Donatella Lucchetti, Sergio Alfieri, Alessandro Sgambato, Emilio Bria, Laura Bizzozero, Sabrina Arena, Stefano Ugel, Vincenzo Corbo, Giampaolo Tortora, Carmine Carbone
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease. This is due to its aggressive course, late diagnosis and its intrinsic drugs resistance. The complexity of the tumor, in terms of cell components and heterogeneity, has
Externí odkaz:
https://doaj.org/article/adbd2731a7444e4995e152ebaac77297
Autor:
Vincenzo Salemme, Mauro Vedelago, Alessandro Sarcinella, Federico Moietta, Alessio Piccolantonio, Enrico Moiso, Giorgia Centonze, Marta Manco, Andrea Guala, Alessia Lamolinara, Costanza Angelini, Alessandro Morellato, Dora Natalini, Raffaele Calogero, Danny Incarnato, Salvatore Oliviero, Laura Conti, Manuela Iezzi, Daniela Tosoni, Giovanni Bertalot, Stefano Freddi, Francesco A. Tucci, Francesco De Sanctis, Cristina Frusteri, Stefano Ugel, Vincenzo Bronte, Federica Cavallo, Paolo Provero, Marta Gai, Daniela Taverna, Emilia Turco, Salvatore Pece, Paola Defilippi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract The p140Cap adaptor protein is a tumor suppressor in breast cancer associated with a favorable prognosis. Here we highlight a function of p140Cap in orchestrating local and systemic tumor-extrinsic events that eventually result in inhibition
Externí odkaz:
https://doaj.org/article/6ef08fc8d1c74047923f8519dfa3b883
Autor:
Annalisa Adamo, Cristina Frusteri, Sara Pilotto, Simone Caligola, Lorenzo Belluomini, Ornella Poffe, Luca Giacobazzi, Silvia Dusi, Chiara Musiu, Yushu Hu, Tian Wang, Davide Rizzini, Antonio Vella, Stefania Canè, Giulia Sartori, Jessica Insolda, Marco Sposito, Ursula Cesta Incani, Carmine Carbone, Geny Piro, Francesca Pettinella, Fang Qi, Dali Wang, Silvia Sartoris, Francesco De Sanctis, Patrizia Scapini, Stefano Dusi, Marco Antonio Cassatella, Emilio Bria, Michele Milella, Vincenzo Bronte, Stefano Ugel
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTCancer cells favor the generation of myeloid cells with immunosuppressive and inflammatory features, including myeloid-derived suppressor cells (MDSCs), which support tumor progression. The anti-apoptotic molecule, cellular FLICE (FADD-like i
Externí odkaz:
https://doaj.org/article/5801fb8ef0cd4ae58a3140fe2943e55c
Autor:
Laura Raccosta, Maura Marinozzi, Susan Costantini, Daniela Maggioni, Lorena Maria Ferreira, Gianfranca Corna, Paola Zordan, Angela Sorice, Diego Farinello, Silvia Bianchessi, Michela Riba, Dejan Lazarevic, Paolo Provero, Matthias Mack, Attilio Bondanza, Ivan Nalvarte, J-A Gustafsson, Valeria Ranzani, Francesco De Sanctis, Stefano Ugel, Silvère Baron, Jean-Marc A. Lobaccaro, Lorenzo Pontini, Manuela Pacciarini, Catia Traversari, Massimiliano Pagani, Vincenzo Bronte, Giovanni Sitia, Per Antonson, Andrea Brendolan, Alfredo Budillon, Vincenzo Russo
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-21 (2023)
Abstract Lipid and cholesterol metabolism play a crucial role in tumor cell behavior and in shaping the tumor microenvironment. In particular, enzymatic and non-enzymatic cholesterol metabolism, and derived metabolites control dendritic cell (DC) fun
Externí odkaz:
https://doaj.org/article/19a1cad6fabb42a1b5100c635b5364ef
Autor:
Tian Wang, Yushu Hu, Silvia Dusi, Fang Qi, Silvia Sartoris, Stefano Ugel, Francesco De Sanctis
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Pattern recognition receptors are primitive sensors that arouse a preconfigured immune response to broad stimuli, including nonself pathogen-associated and autologous damage-associated molecular pattern molecules. These receptors are mainly expressed
Externí odkaz:
https://doaj.org/article/65ea1bc56f084ee6afa2704dd5cfd2b1
Autor:
Sara Costa, Dalila Bevilacqua, Elena Caveggion, Sara Gasperini, Elena Zenaro, Francesca Pettinella, Marta Donini, Stefano Dusi, Gabriela Constantin, Silvia Lonardi, William Vermi, Francesco De Sanctis, Stefano Ugel, Tiziana Cestari, Clare L. Abram, Clifford A. Lowell, Pamela Rodegher, Franco Tagliaro, Giampiero Girolomoni, Marco A. Cassatella, Patrizia Scapini
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundPsoriasis is a chronic skin disease associated with deregulated interplays between immune cells and keratinocytes. Neutrophil accumulation in the skin is a histological feature that characterizes psoriasis. However, the role of neutrophils
Externí odkaz:
https://doaj.org/article/b8b37b1a6ace4838bb7bd76f755ac86f
Autor:
Rachele Ciccocioppo, Davide Gibellini, Giuseppe Astori, Martina Bernardi, Angela Bozza, Katia Chieregato, Francesca Elice, Stefano Ugel, Simone Caligola, Francesco De Sanctis, Stefania Canè, Alessandra Fiore, Rosalinda Trovato, Antonio Vella, Varvara Petrova, Giuseppe Amodeo, Monica Santimaria, Annarita Mazzariol, Luca Frulloni, Marco Ruggeri, Enrico Polati, Vincenzo Bronte
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2021)
Abstract Coronavirus disease 2019 (COVID-19) may result in a life-threatening condition due to a hyperactive immune reaction to severe acute respiratory syndrome-coronavirus-2 infection, for which no effective treatment is available. Based on the pot
Externí odkaz:
https://doaj.org/article/839d6e18c96343b4a471f55182d1991a
Autor:
Pierre Bost, Francesco De Sanctis, Stefania Canè, Stefano Ugel, Katia Donadello, Monica Castellucci, David Eyal, Alessandra Fiore, Cristina Anselmi, Roza Maria Barouni, Rosalinda Trovato, Simone Caligola, Alessia Lamolinara, Manuela Iezzi, Federica Facciotti, Annarita Mazzariol, Davide Gibellini, Pasquale De Nardo, Evelina Tacconelli, Leonardo Gottin, Enrico Polati, Benno Schwikowski, Ido Amit, Vincenzo Bronte
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Integrated studies of matched tissue sites and cell types in COVID-19 patients are important to define the immune mechanisms of pathology. Here, the authors describe an immune signature in fatal COVID-19 patients harmonizing single-cell RNA sequencin
Externí odkaz:
https://doaj.org/article/479c40aff76e43fcad6b8bae647af648