Insight into motor fatigue mechanisms in natalizumab treated multiple sclerosis patients with wearing off

Autor: Giorgio Leodori, Marco Mancuso, Davide Maccarrone, Matteo Tartaglia, Antonio Ianniello, Francesco Certo, Gina Ferrazzano, Leonardo Malimpensa, Daniele Belvisi, Carlo Pozzilli, Alfredo Berardelli, Antonella Conte

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract Motor fatigue in Multiple Sclerosis (MS) is due to reduced motor cortex (M1) output and altered sensorimotor network (SMN) modulation. Natalizumab, a disease-modifying therapy, reduces neuroinflammation and improves fatigue. However, some pa

Externí odkaz: https://doaj.org/article/6c0eebf121d8490ebeb62a1a97030d31

The impact of COVID-19 pandemic on surgical neuro-oncology: A survey from the Italian society of neurosurgery (SINch)

Autor: Luca Zanin, Tamara Ius, Pier Paolo Panciani, Felice Esposito, Andrea Gori, Marco Maria Fontanella, Maria Pia Tropeano, Antonino Raco, Filippo Flavio Angileri, Giovanni Sabatino, Alessandro Olivi, Vincenzo Esposito, Federico Pessina, Edoardo Agosti, Salvatore Aiello, Denis Aiudi, Danilo Aleo, Roberto Altieri, Rosina Amoroso, Anna Maria Auricchio, Giuseppe Barbagallo, Andrea Barbanera, Giacomo Beggio, Andrea Bianco, Riccardo Boccaletti, Stefano Borsa, Giuseppe Canova, Paolo Cappabianca, Manuela Caroli, Michele Alessandro Cavallo, Francesco Certo, Marcella Chimenti, Franco Chioffi, Valentina Cioffi, Fabio Cofano, Christian Cossandi, Giancarlo D’Andrea, Raffaele De Falco, Alessandro D'Elia, Giuseppe Maria Della Pepa, Alessandro Della Puppa, Attilio Della Torre, Paolo Ferroli, Diego Garbossa, Antonino Germanò, Alessandra Giaquinta, Franco Guida, Maurizio Iacoangeli, Domenico Gerardo Iacopino, Angelo Lavano, Giuseppe Maimone, Vincenza Maiola, Rosario Mauferi, Alessandro Melatini, Mario Moro, Domenico Murrone, Giovanni Muscas, Piero Andrea Oppido, Fabrizio Pignotti, Domenico Policicchio, Piermassimo Proto, Paolo Quaglietta, Giulia Renisi, Luca Ricciardi, Francesco Romeo, Marta Rossetto, Alba Scerrati, Andreas Schwarz, Miran Skrap, Carlo Somma, Teresa Somma, Giannantonio Spena, Stefano Telera, Luigino Tosatto, Francesco Volpin, Lorenzo Volpin, Cesare Zoia

Publikováno v: World Neurosurgery: X, Vol 20, Iss , Pp 100233- (2023)

Background: The COVID-19 pandemic and its impact on hospitals' activity and organization has imposed a vast change in standard neurosurgical oncology practice to accommodate for shifting resources. Aims: This investigation aims to analyse the nationw

Externí odkaz: https://doaj.org/article/790f973e44de499b9b47bf73b02fc163

Feasibility on the Use of Radiomics Features of 11[C]-MET PET/CT in Central Nervous System Tumours: Preliminary Results on Potential Grading Discrimination Using a Machine Learning Model

Autor: Giorgio Russo, Alessandro Stefano, Pierpaolo Alongi, Albert Comelli, Barbara Catalfamo, Cristina Mantarro, Costanza Longo, Roberto Altieri, Francesco Certo, Sebastiano Cosentino, Maria Gabriella Sabini, Selene Richiusa, Giuseppe Maria Vincenzo Barbagallo, Massimo Ippolito

Publikováno v: Current Oncology, Vol 28, Iss 6, Pp 5318-5331 (2021)

Background/Aim: Nowadays, Machine Learning (ML) algorithms have demonstrated remarkable progress in image-recognition tasks and could be useful for the new concept of precision medicine in order to help physicians in the choice of therapeutic strateg

Externí odkaz: https://doaj.org/article/73d020f5e42d4033b7d6668f8547a335

A Custom DNA-Based NGS Panel for the Molecular Characterization of Patients With Diffuse Gliomas: Diagnostic and Therapeutic Applications

Autor: Elena Tirrò, Michele Massimino, Giuseppe Broggi, Chiara Romano, Simone Minasi, Francesca Gianno, Manila Antonelli, Gianmarco Motta, Francesco Certo, Roberto Altieri, Livia Manzella, Rosario Caltabiano, Giuseppe Maria Vincenzo Barbagallo, Francesca Romana Buttarelli, Gaetano Magro, Felice Giangaspero, Paolo Vigneri

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

The management of patients with Central Nervous System (CNS) malignancies relies on the appropriate classification of these tumors. Recently, the World Health Organization (WHO) has published new criteria underlining the importance of an accurate mol

Externí odkaz: https://doaj.org/article/8b4a7086a7bf44bdb5b01f6967f63c5b

Histologic Definition of Enhancing Core and FLAIR Hyperintensity Region of Glioblastoma, IDH-Wild Type: A Clinico-Pathologic Study on a Single-Institution Series

Autor: Giuseppe Broggi, Roberto Altieri, Valeria Barresi, Francesco Certo, Giuseppe Maria Vincenzo Barbagallo, Magda Zanelli, Andrea Palicelli, Gaetano Magro, Rosario Caltabiano

Publikováno v: Brain Sciences, Vol 13, Iss 2, p 248 (2023)

The extent of resection beyond the enhancing core (EC) in glioblastoma IDH-wild type (GBM, IDHwt) is one of the most debated topics in neuro-oncology. Indeed, it has been demonstrated that local disease recurrence often arises in peritumoral areas an

Externí odkaz: https://doaj.org/article/094277b154c64a478cea6d89dbb8d688