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Identification of a novel nucleophosmin‐interaction motif in the tumor suppressor p14arf

Autor: Luca Federici, Maurizio Brunori, Sara Chiarella, Lucia Banci, Adele Di Matteo, Mimma Franceschini, Enrico Luchinat

Publikováno v: The FEBS journal
285 (2018): 832–847. doi:10.1111/febs.14373
info:cnr-pdr/source/autori:Luchinat, Enrico; Chiarella, Sara; Franceschini, Mimma; Di Matteo, Adele; Brunori, Maurizio; Banci, Lucia; Federici, Luca/titolo:Identification of a novel nucleophosmin-interaction motif in the tumor suppressor p14arf/doi:10.1111%2Ffebs.14373/rivista:The FEBS journal (Print)/anno:2018/pagina_da:832/pagina_a:847/intervallo_pagine:832–847/volume:285

The tumor suppressor p14arf interacts, in response to oncogenic signals, with the p53 E3-ubiquitin ligase HDM2, thereby resulting in p53 stabilization and activation. In addition, it also exerts tumor-suppressive functions in p53-independent contexts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1451763616d5ceadea0d84e3cdf9b5
https://doi.org/10.1111/febs.14373