Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Francesca de Giorgi"'
Autor:
Florent Laferrière, Ludivine Sabatier, Stéphane Claverol, Francesca De Giorgi, François Ichas
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/f5fe1506ee4b493c9412bf2ef7b5a4f5
Publikováno v:
Ecology and Evolution, Vol 14, Iss 5, Pp n/a-n/a (2024)
Abstract Plant species respond to varying plant species diversity and associated changes in their abiotic and biotic environment with changes in their phenotype. However, it is not clear to what degree this phenotypic differentiation is due to genoty
Externí odkaz:
https://doaj.org/article/f27e5d7d7a434292a39583b8a980ff4d
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Aggregated alpha-synuclein (α-syn) is a principal constituent of Lewy bodies (LBs) and glial cytoplasmic inclusions (GCIs) observed respectively inside neurons in Parkinson’s disease (PD) and oligodendrocytes in multiple system atrophy (M
Externí odkaz:
https://doaj.org/article/13aeb9dae7834cae80e5f9f65fd4b4b2
Autor:
Luigi Scietti, Elisabetta Moroni, Daiana Mattoteia, Marco Fumagalli, Matteo De Marco, Lisa Negro, Antonella Chiapparino, Stefano A. Serapian, Francesca De Giorgi, Silvia Faravelli, Giorgio Colombo, Federico Forneris
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Multifunctional human collagen lysyl hydroxylase (LH/PLOD) enzymes catalyze post-translational hydroxylation and subsequent glycosylation of collagens, enabling their maturation and supramolecular organization in the extracellular matrix (ECM). Recen
Externí odkaz:
https://doaj.org/article/b6a66bc99baa419fbaa8c133faca3ec4
Autor:
Francesco De Nuccio, Marianna Kashyrina, Francesca Serinelli, Florent Laferrière, Dario Domenico Lofrumento, Francesca De Giorgi, François Ichas
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 269 (2023)
α-Synucleinopathies are spreading neurodegenerative disorders characterized by the intracellular accumulation of insoluble aggregates populated by α-Synuclein (α-Syn) fibrils. In Parkinson’s disease (PD) and dementia with Lewy bodies, intraneuro
Externí odkaz:
https://doaj.org/article/d13b84f8a4d84edaa43496e217a33354
Autor:
Sabine Schmidhuber, Sandra Scheiblhofer, Richard Weiss, Mihály Cserepes, József Tóvári, Gabriele Gadermaier, Erwan Bezard, Francesca De Giorgi, François Ichas, Dirk Strunk, Markus Mandler
Publikováno v:
Vaccines, Vol 10, Iss 9, p 1432 (2022)
The progressive accumulation of misfolded α-synuclein (α-syn) in the brain is widely considered to be causal for the debilitating clinical manifestations of synucleinopathies including, most notably, Parkinson’s disease (PD). Immunotherapies, bot
Externí odkaz:
https://doaj.org/article/0e6a5cdac3be49cf99aba6c1fc8434f6
Publikováno v:
Biomolecules, Vol 12, Iss 4, p 494 (2022)
In 1957, Lionel Penrose built the first man-made self-replicating mechanical device and illustrated its function in a series of machine prototypes, prefiguring our current view of the genesis and the proliferation of amyloid fibrils. He invented and
Externí odkaz:
https://doaj.org/article/6134a3b9970e48c0ad92f19947ab990a
Autor:
Francesca De Giorgi, Muhammed Bilal Abdul-Shukkoor, Marianna Kashyrina, Leslie-Ann Largitte, Francesco De Nuccio, Brice Kauffmann, Alons Lends, Florent Laferrière, Sébastien Bonhommeau, Dario Domenico Lofrumento, Luc Bousset, Erwan Bezard, Thierry Buffeteau, Antoine Loquet, François Ichas
Publikováno v:
Biomolecules, Vol 12, Iss 3, p 436 (2022)
The distinct neuropathological features of the different α-Synucleinopathies, as well as the diversity of the α-Synuclein (α-Syn) intracellular inclusion bodies observed in post mortem brain sections, are thought to reflect the strain diversity ch
Externí odkaz:
https://doaj.org/article/34f9e9e221c14a529714a48aa810e239
Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
Autor:
Luigi Scietti, Antonella Chiapparino, Francesca De Giorgi, Marco Fumagalli, Lela Khoriauli, Solomon Nergadze, Shibom Basu, Vincent Olieric, Lucia Cucca, Blerida Banushi, Antonella Profumo, Elena Giulotto, Paul Gissen, Federico Forneris
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Lysyl hydroxylase 3 (LH3) catalyzes collagen lysine hydroxylation and their subsequent O-linked glycosylation. Here the authors provide mechanistic insights into the lysyl hydroxylase and glycosyltransferase activities of LH3 by determining the cryst
Externí odkaz:
https://doaj.org/article/9671310693c340349b00e760061a12e1
Autor:
Fabio Cavaliere, Loic Cerf, Benjamin Dehay, Paula Ramos-Gonzalez, Francesca De Giorgi, Mathieu Bourdenx, Alban Bessede, Jose A. Obeso, Carlos Matute, François Ichas, Erwan Bezard
Publikováno v:
Neurobiology of Disease, Vol 103, Iss , Pp 101-112 (2017)
Synucleinopathies are a group of diseases characterized by the presence of intracellular protein aggregates containing α-synuclein (α-syn). While α-syn aggregates have been shown to induce multimodal cellular dysfunctions, uptake and transport mec
Externí odkaz:
https://doaj.org/article/0dba46ea00a241c991c20e477500ae96