Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Francesca Zappacosta"'
Autor:
Kevin McKinski, Dean McNulty, Francesca Zappacosta, Mary Birchler, Matt Szapacs, Christopher Evans
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 12, Iss 2, Pp 317-323 (2022)
Inducible T-cell costimulator (ICOS), a homodimeric protein expressed on the surface of activated T-cells, is being investigated as a potential therapeutic target to treat various cancers. Recent studies have reported aberrant increases in the solubl
Externí odkaz:
https://doaj.org/article/5cc714bd87f34705a309ec919ef3f022
Autor:
Gisela Jimenez-Duran, Joseph Kozole, Rachel Peltier-Heap, Eleanor R. Dickinson, Christopher R. Kwiatkowski, Francesca Zappacosta, Roland S. Annan, Nicholas W. Galwey, Eva-Maria Nichols, Louise K. Modis, Martha Triantafilou, Kathy Triantafilou, Lee M. Booty
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The complement system is an ancient and critical part of innate immunity. Recent studies have highlighted novel roles of complement beyond lysis of invading pathogens with implications in regulating the innate immune response, as well as contributing
Externí odkaz:
https://doaj.org/article/18224861a8b0475c8ebbec8ed8c12015
Autor:
Paul B. Noto, Timothy W. Sikorski, Francesca Zappacosta, Craig D. Wagner, Rocio Montes de Oca, Matthew E. Szapacs, Roland S. Annan, Yan Liu, Charles F. McHugh, Helai P. Mohammad, Steven P. Piccoli, Caretha L. Creasy
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Abstract Arginine methylation has been recognized as a post-translational modification with pleiotropic effects that span from regulation of transcription to metabolic processes that contribute to aberrant cell proliferation and tumorigenesis. This h
Externí odkaz:
https://doaj.org/article/414cd6e4587d4953aac439af4a476cd3
Autor:
Ross P. Thomas, Emma K. Grant, Eleanor R. Dickinson, Francesca Zappacosta, Lee J. Edwards, Michael M. Hann, David House, Nicholas C. O. Tomkinson, Jacob T. Bush
Publikováno v:
RSC Medicinal Chemistry. 14:671-679
We present a carboxylate-targeting reactive fragment screening platform using 2-aryl-5-carboxytetrazole (ACT) as the photoreactive functionality. This work will provide a simple accessible method to rapidly discover tool molecules to interrogate impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd3b68948d6bbe3fe003bc8768957b21
https://doi.org/10.1039/d2md00453d
https://doi.org/10.1039/d2md00453d
Autor:
Arron Aatkar, Aini Vuorinen, Oliver E. Longfield, Katharine Gilbert, Rachel Peltier-Heap, Craig D. Wagner, Francesca Zappacosta, Katrin Rittinger, Chun-wa Chung, David House, Nicholas C. O. Tomkinson, Jacob T. Bush
Publikováno v:
ACS Chemical Biology.
Sulfur(VI) fluorides (SFs) have emerged as valuable electrophiles for the design of 'beyond cysteine' covalent inhibitors, and offer potential for expansion of the liganded proteome. Since SFs target a broad range of nucleophilic amino acids, they de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e549ee29bfb50bf0d4a55e881a9deeae
https://doi.org/10.1021/acschembio.3c00034
https://doi.org/10.1021/acschembio.3c00034
Autor:
Sylvie G. Laquerre, David Sutton, Roland Annan, Francesca Zappacosta, Jingsong Yang, Kelly E. Fisher, Symon Erskine, Cynthia M. Rominger, Swarupa G. Kulkarni, Elisabeth A. Minthorn, Katherine G. Moss, Arthur Groy, Maureen R. Bleam, Aidan G. Gilmartin
Supplementary Figures S1-S6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7058b2fa24465f2173cd06088172f582
https://doi.org/10.1158/1078-0432.22443324.v1
https://doi.org/10.1158/1078-0432.22443324.v1
Autor:
Sylvie G. Laquerre, David Sutton, Roland Annan, Francesca Zappacosta, Jingsong Yang, Kelly E. Fisher, Symon Erskine, Cynthia M. Rominger, Swarupa G. Kulkarni, Elisabeth A. Minthorn, Katherine G. Moss, Arthur Groy, Maureen R. Bleam, Aidan G. Gilmartin
Purpose: Despite their preclinical promise, previous MEK inhibitors have shown little benefit for patients. This likely reflects the narrow therapeutic window for MEK inhibitors due to the essential role of the P42/44 MAPK pathway in many nontumor ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d39348d02bb57cb5edbc2432031aee
https://doi.org/10.1158/1078-0432.c.6519777
https://doi.org/10.1158/1078-0432.c.6519777
Autor:
Francesca Zappacosta, Dean E. McNulty, Mary Birchler, Christopher P. Evans, Matt Szapacs, Kevin McKinski
Publikováno v:
Journal of Pharmaceutical Analysis. 12:317-323
Inducible T-cell costimulator (ICOS) is a homodimeric protein expressed on the surface of activated T-cells that is being investigated as a potential therapeutic target to treat various cancers. Recent studies have reported aberrant increases in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce1232e39879d84f2a4ba865cc3bde9
https://doi.org/10.1016/j.jpha.2021.06.008
https://doi.org/10.1016/j.jpha.2021.06.008
Autor:
Marcus Bantscheff, Christian Eberl, Chun-wa Chung, Nicholas C. O. Tomkinson, Stephanie Lehmann, Ken G. M. Fantom, Jacob T. Bush, Alex Phillipou, Christopher J. Schofield, Francesca Zappacosta, David J. Fallon, Vipulkumar Kantibhai Patel
Publikováno v:
Chemistry – A European Journal. 27:17880-17888
We present a one-step Ugi reaction protocol for the expedient synthesis of photoaffinity probes for live-cell MS-based proteomics. The reaction couples an amine affinity function with commonly used photoreactive groups, and a variety of handle functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a79025963083ff808e540ac30b35fa0
https://doi.org/10.1002/chem.202102036
https://doi.org/10.1002/chem.202102036
Autor:
Emma K. Grant, Francesca Zappacosta, Peter Pogány, Michael M. Hann, Nicholas C. O. Tomkinson, David House, Ross P. Thomas, Jacob T. Bush, David J. Fallon, Rachel E. Heap, Stephen Besley
Publikováno v:
Chemical Science
Methods for rapid identification of chemical tools are essential for the validation of emerging targets and to provide medicinal chemistry starting points for the development of new medicines. Here, we report a screening platform that combines ‘dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c329d190f9f1199ac07fac7c57d5ee73
http://europepmc.org/articles/PMC8457371
http://europepmc.org/articles/PMC8457371