Safety and Immunogenicity of a Carbohydrate Fatty Acid Monosulphate Ester Adjuvant Combined with a Low-Dose Quadrivalent Split-Virion Inactivated Influenza Vaccine: A Randomised, Observer-Blind, Active-Controlled, First-in-Human, Phase 1 Study

Autor: Valentino D’Onofrio, Sharon Porrez, Bart Jacobs, Azhar Alhatemi, Fien De Boever, Gwenn Waerlop, Els Michels, Francesca Vanni, Alessandro Manenti, Geert Leroux-Roels, Peter Paul Platenburg, Luuk Hilgers, Isabel Leroux-Roels

Publikováno v: Vaccines, Vol 12, Iss 9, p 1036 (2024)

Seasonal influenza vaccine effectiveness is low. Carbohydrate fatty acid monosulphate ester (CMS), a new oil-in-water adjuvant, has proven potency in animal models with suggested capacity for dose-sparing. The objective was to evaluate safety and imm

Externí odkaz: https://doaj.org/article/5ca3304e712c41af9db534402afe1e73

Systemic Inflammation Rapidly Induces Reversible Atrial Electrical Remodeling: The Role of Interleukin‐6–Mediated Changes in Connexin Expression

Autor: Pietro Enea Lazzerini, Franco Laghi‐Pasini, Maurizio Acampa, Ujala Srivastava, Iacopo Bertolozzi, Beatrice Giabbani, Francesco Finizola, Francesca Vanni, Aleksander Dokollari, Mariarita Natale, Gabriele Cevenini, Enrico Selvi, Nicola Migliacci, Massimo Maccherini, Mohamed Boutjdir, Pier Leopoldo Capecchi

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 16 (2019)

Background Systemic inflammation is a strong predictor of atrial fibrillation. A key role for electrical remodeling is increasingly recognized, and experimental data suggest that inflammatory cytokines can directly affect connexins resulting in gap�

Externí odkaz: https://doaj.org/article/d27842b344224b84b3f2418fc525535e

Searching Novel Therapeutic Targets for Scleroderma: P2X7-Receptor Is Up-regulated and Promotes a Fibrogenic Phenotype in Systemic Sclerosis Fibroblasts

Autor: Daniela Gentile, Pietro E. Lazzerini, Alessandra Gamberucci, Mariarita Natale, Enrico Selvi, Francesca Vanni, Alessandra Alì, Paolo Taddeucci, Silvia Del-Ry, Manuela Cabiati, Veronica Della-Latta, David J. Abraham, Maria A. Morales, Rosella Fulceri, Franco Laghi-Pasini, Pier L. Capecchi

Publikováno v: Frontiers in Pharmacology, Vol 8 (2017)

Objectives: Systemic sclerosis (SSc) is a connective tissue disorder presenting fibrosis of the skin and internal organs, for which no effective treatments are currently available. Increasing evidence indicates that the P2X7 receptor (P2X7R), a nucle

Externí odkaz: https://doaj.org/article/5b16d5004cd94d4389366910e179d482

Unravelling Atrioventricular Block Risk in Inflammatory Diseases: Systemic Inflammation Acutely Delays Atrioventricular Conduction via a Cytokine-Mediated Inhibition of Connexin43 Expression

Autor: Alessandro Frosali, Decoroso Verrengia, Alessandra Gamberucci, Mohamed Boutjdir, Francesca Vanni, Franco Laghi-Pasini, Aleksander Dokollari, Pier Leopoldo Capecchi, Alessandra Cartocci, Maurizio Acampa, Nabil El-Sherif, Claudio Nanni, Antonio D'Errico, Pietro Enea Lazzerini, Ujala Srivastava, Iacopo Bertolozzi, Anna Cantore, Michael Cupelli, Fabio Salvadori, Viola Salvini, Riccardo Accioli, Massimo Maccherini

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 21 (2021)

Background Recent data suggest that systemic inflammation can negatively affect atrioventricular conduction, regardless of acute cardiac injury. Indeed, gap‐junctions containing connexin43 coupling cardiomyocytes and inflammation‐related cells (m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a14dc0ad90d1930ab3b7ed13e58cc2a
https://pubmed.ncbi.nlm.nih.gov/34713715

Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation

Autor: Francesca Vanni, Niamh H McCabe, Stefania Lamponi, Cristina Ulivieri, Federica Sarno, Fulvio Saccoccia, Sandra Gemma, Giulia Chemi, David W. Christianson, Ola Ibrahim, Margherita Brindisi, Simone Brogi, Giovina Ruberti, Stefano Federico, Manfred Jung, Giuseppe Campiani, Nicola Relitti, Vincent P. Kelly, Daniela M. Zisterer, Stefania Butini, Richard C. Turkington, Antonella Di Costanzo, Patricia Hannon Barroeta, Rebecca Amet, Lucia Altucci, Magda Ghanim, Jeff O'Sullivan, Alessandro Grillo, Jeremy D. Osko, A Prasanth Saraswati, Daniel Herp

Publikováno v: Saraswati, A P, Relitti, N, Brindisi, M, Osko, J D, Chemi, G, Federico, S, Grillo, A, Brogi, S, McCabe, N H, Turkington, R C, Ibrahim, O, O'Sullivan, J, Lamponi, S, Ghanim, M, Kelly, V P, Zisterer, D, Amet, R, Hannon Barroeta, P, Vanni, F, Ulivieri, C, Herp, D, Sarno, F, Di Costanzo, A, Saccoccia, F, Ruberti, G, Jung, M, Altucci, L, Gemma, S, Butini, S, Christianson, D W & Campiani, G 2020, ' Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation ', ACS MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 11, pp. 2268-2276 . https://doi.org/10.1021/acsmedchemlett.0c00395
ACS Med Chem Lett
ACS medicinal chemistry letters (2020). doi:10.1021/acsmedchemlett.0c00395
info:cnr-pdr/source/autori:A Prasanth Saraswati 1, Nicola Relitti 1, Margherita Brindisi 1, Jeremy D Osko 2, Giulia Chemi 1, Stefano Federico 1, Alessandro Grillo 1, Simone Brogi 3, Niamh H McCabe 4, Richard C Turkington 4, Ola Ibrahim 5, Jeffrey O'Sullivan 5, Stefania Lamponi 1, Magda Ghanim 6, Vincent P Kelly 6, Daniela Zisterer 6, Rebecca Amet 6, Patricia Hannon Barroeta 6, Francesca Vanni 7, Cristina Ulivieri 7, Daniel Herp 8, Federica Sarno 9, Antonella Di Costanzo 9, Fulvio Saccoccia 10, Giovina Ruberti 10, Manfred Jung 8, Lucia Altucci 9, Sandra Gemma 1, Stefania Butini 1, David W Christianson 2, Giuseppe Campiani/titolo:Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation/doi:10.1021%2Facsmedchemlett.0c00395/rivista:ACS medicinal chemistry letters/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
ACS Medicinal Chemistry Letters

[Image: see text] Histone deacetylase inhibitors (HDACi) have emerged as promising therapeutics for the treatment of neurodegeneration, cancer, and rare disorders. Herein, we report the development of a series of spiroindoline-based HDAC6 isoform-sel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdda0b9bb58feac3ff72ae889a7ab41
https://pure.qub.ac.uk/en/publications/spiroindolinecapped-selective-hdac6-inhibitors-design-synthesis-structural-analysis-and-biological-evaluation(5bed77f3-2eb8-4bef-8802-360242d740c1).html