Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Francesca Stillitano"'
Autor:
Valentina Balducci, Francesco Scardigli, Magdalena Harakalova, J. Peter. van Tintelen, Pieter A. Doevendans, Kevin D. Costa, Irene C. Turnbull, Joost P. G. Sluijter, Francesca Stillitano
Publikováno v:
Stem Cell Research, Vol 72, Iss , Pp 103208- (2023)
The rare genetic alteration PLN-c.(40_42delAGA), leading to the deletion of arginine 14 (p.R14del) in phospholamban, is associated with dilated and arrhythmogenic cardiomyopathies occurring in early-adulthood. However, some carriers remain asymptomat
Externí odkaz:
https://doaj.org/article/388758bbc8f347e6ba63047bd7670b59
Autor:
Nishka Mittal, Jaydev Dave, Magdalena Harakalova, J. Peter. van Tintelen, Folkert W. Asselbergs, Pieter A. Doevendans, Kevin D. Costa, Irene C. Turnbull, Francesca Stillitano
Publikováno v:
Stem Cell Research, Vol 60, Iss , Pp 102737- (2022)
The R14del pathogenic variant in the phospholamban (PLN) gene (PLN-R14del), has been identified in families with hereditary cardiomyopathy, including dilated and arrhythmogenic cardiomyopathies. Here we have generated human iPSC lines from five PLN-R
Externí odkaz:
https://doaj.org/article/42ffbf12f2cb4306961af5cb94213fa4
Autor:
Mohit Kumar, Kobra Haghighi, Sheryl Koch, Jack Rubinstein, Francesca Stillitano, Roger J. Hajjar, Evangelia G. Kranias, Sakthivel Sadayappan
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2675 (2023)
Phospholamban (PLN) is a major regulator of cardiac contractility, and human mutations in this gene give rise to inherited cardiomyopathies. The deletion of Arginine 14 is the most-prevalent cardiomyopathy-related mutation, and it has been linked to
Externí odkaz:
https://doaj.org/article/c3e75532ebfe4737b2a1a4a70797679d
Autor:
Jack F. Murphy, Joshua Mayourian, Francesca Stillitano, Sadek Munawar, Kathleen M. Broughton, Esperanza Agullo-Pascual, Mark A. Sussman, Roger J. Hajjar, Kevin D. Costa, Irene C. Turnbull
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-19 (2019)
Abstract Background Delivery of stem cells to the failing heart is a promising therapeutic strategy. However, the improvement in cardiac function in animal studies has not fully translated to humans. To help bridge the gap between species, we investi
Externí odkaz:
https://doaj.org/article/9a9bde06e28e4ec3b138f70b770bbe62
Autor:
Francesca Stillitano, Jens Hansen, Chi-Wing Kong, Ioannis Karakikes, Christian Funck-Brentano, Lin Geng, Stuart Scott, Stephan Reynier, Ma Wu, Yannick Valogne, Carole Desseaux, Joe-Elie Salem, Dorota Jeziorowska, Noël Zahr, Ronald Li, Ravi Iyengar, Roger J Hajjar, Jean-Sébastien Hulot
Publikováno v:
eLife, Vol 6 (2017)
A large number of drugs can induce prolongation of cardiac repolarization and life-threatening cardiac arrhythmias. The prediction of this side effect is however challenging as it usually develops in some genetically predisposed individuals with norm
Externí odkaz:
https://doaj.org/article/3b878456b2a444ebbdf9d3342f144ebc
Publikováno v:
Journal of Clinical and Translational Science, Vol 2, Pp 9-10 (2018)
OBJECTIVES/SPECIFIC AIMS: The goals of this study are to develop a human-based screening assay for testing individual drug reactions and investigate the mechanism underlying susceptibility to develop diLQT. METHODS/STUDY POPULATION: We derived iPSC-C
Externí odkaz:
https://doaj.org/article/26b9c8bac45e4c1f88d7fb7feed12a6e
Publikováno v:
Journal of Clinical and Translational Science, Vol 3, Pp 8-8 (2019)
OBJECTIVES/SPECIFIC AIMS: The goals of this study were (1) to evaluate the effect of proarrhythmic drugs on calcium transient and (2) to use three-dimensional human engineered cardiac tissue (hECT) technology to evaluate cardiac contractile propertie
Externí odkaz:
https://doaj.org/article/2c535628628a4c4fa0520fcdd2a3edc9
Autor:
Maria Giovanna Trivieri, Francesca Stillitano, Delaine Ceholski, Irene Turnbull, Kevin Costa, Thomas Weber, Kenneth Fish, Evangelia Kranias, Roger Hajjar
Publikováno v:
Journal of Clinical and Translational Science, Vol 3, Pp 26-26 (2019)
OBJECTIVES/SPECIFIC AIMS: To study the biology of Phosholamban (PLN) in a human relevant model. METHODS/STUDY POPULATION: State of the art stem-cell technologies using iPSC-CMs derived from carriers of a lethal PLN mutation. RESULTS/ANTICIPATED RESUL
Externí odkaz:
https://doaj.org/article/add6508bc87d453fa71a94fb3a120355
Autor:
Kleopatra Rapti, Francesca Stillitano, Ioannis Karakikes, Mathieu Nonnenmacher, Thomas Weber, Jean-Sebastian Hulot, Roger J Hajjar
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)
Human embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) assert a great future for the cardiovascular diseases, both to study them and to explore therapies. However, a comprehensive assessment of the viral vectors used to modify t
Externí odkaz:
https://doaj.org/article/298f46d9a0274776840904672ef93bd8
Autor:
Leonardo Bocchi, Monia Savi, Gallia Graiani, Stefano Rossi, Aldo Agnetti, Francesca Stillitano, Costanza Lagrasta, Silvana Baruffi, Roberta Berni, Caterina Frati, Mario Vassalle, Umberto Squarcia, Elisabetta Cerbai, Emilio Macchi, Donatella Stilli, Federico Quaini, Ezio Musso
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17750 (2011)
Heart repair by stem cell treatment may involve life-threatening arrhythmias. Cardiac progenitor cells (CPCs) appear best suited for reconstituting lost myocardium without posing arrhythmic risks, being commissioned towards cardiac phenotype. In this
Externí odkaz:
https://doaj.org/article/25718372cf8949d1aae3b1a499700e19