Molecular Mechanisms Underlying the Antitumor Activity of 3-Aminopropanamide Irreversible Inhibitors of the Epidermal Growth Factor Receptor in Non–Small Cell Lung Cancer

Autor: Elena Galvani, Elisa Giovannetti, Francesca Saccani, Andrea Cavazzoni, Leticia G. Leon, Henk Dekker, Roberta Alfieri, Caterina Carmi, Marco Mor, Andrea Ardizzoni, Pier Giorgio Petronini, Godefridus J. Peters

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 1, Pp 61-72 (2013)

Overcoming the emergence of acquired resistance to clinically approved epidermal growth factor receptor (EGFR) inhibitors is a major challenge in the treatment of advanced non–small cell lung cancer (NSCLC). The aim of this study was to investigate

Externí odkaz: https://doaj.org/article/367d37976e004f8fb81e5fe6353c68fd

Gefitinib inhibits invasive phenotype and epithelial-mesenchymal transition in drug-resistant NSCLC cells with MET amplification.

Autor: Silvia La Monica, Cristina Caffarra, Francesca Saccani, Elena Galvani, Maricla Galetti, Claudia Fumarola, Mara Bonelli, Andrea Cavazzoni, Daniele Cretella, Rita Sirangelo, Rita Gatti, Marcello Tiseo, Andrea Ardizzoni, Elisa Giovannetti, Pier Giorgio Petronini, Roberta R Alfieri

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e78656 (2013)

Despite the initial response, all patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) eventually develop acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). The EGFR-T790M secondary mutation is r

Externí odkaz: https://doaj.org/article/0453d80417f14fe09c54dd382da67dc1

Supplementary Tables S1-S5 from Inhibition of PI3K Pathway Reduces Invasiveness and Epithelial-to-Mesenchymal Transition in Squamous Lung Cancer Cell Lines Harboring PIK3CA Gene Alterations

Autor: Andrea Ardizzoni, Pier Giorgio Petronini, Marcello Tiseo, Claudia Fumarola, Pietro Rossetti, Angela Falco, Costanza Annamaria Lagrasta, Caterina Frati, Denise Madeddu, Cristina Caffarra, Daniele Cretella, Maricla Galetti, Silvia La Monica, Federico Quaini, Roberta R. Alfieri, Francesca Saccani, Andrea Cavazzoni, Mara A. Bonelli

Supplementary Tables S1-S5. Table S1: Antiproliferative effects of PI3K inhibitors on SKMES-1 and PIK3CA amplified/mutated clones Tables S2-S4: densitometric analysis of Western blotting of Figure 1D Table S5: Antiproliferative effects of PI3K inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e69b71948c3fa52cb952394674c5eaf
https://doi.org/10.1158/1535-7163.22502805.v1

Design, Synthesis, and Biological Characterization of Inhaled p38α/β MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases

Autor: Elisabetta Armani, Carmelida Capaldi, Valentina Bagnacani, Francesca Saccani, Giancarlo Aquino, Paola Puccini, Fabrizio Facchinetti, Cataldo Martucci, Nadia Moretto, Gino Villetti, Riccardo Patacchini, Maurizio Civelli, Chris Hurley, Andrew Jennings, Lilian Alcaraz, Dawn Bloomfield, Michael Briggs, Stephen Daly, Terry Panchal, Vince Russell, Sharon Wicks, Harry Finch, Mary Fitzgerald, Craig Fox, Maurizio Delcanale

Publikováno v: Journal of Medicinal Chemistry. 65:7170-7192

The identification of novel inhaled p38α/β mitogen-activated protein kinases (MAPK) (MAPK14/11) inhibitors suitable for the treatment of pulmonary inflammatory conditions has been described. A rational drug design approach started from the identifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::479680e047f3d911cb0616fbd692706c
https://doi.org/10.1021/acs.jmedchem.2c00115

Molecular Mechanisms Underlying the Antitumor Activity of 3-Aminopropanamide Irreversible Inhibitors of the Epidermal Growth Factor Receptor in Non–Small Cell Lung Cancer

Autor: Francesca Saccani, Roberta Alfieri, Pier Giorgio Petronini, Godefridus J. Peters, Elena Galvani, Andrea Cavazzoni, Henk L. Dekker, Elisa Giovannetti, Marco Mor, Leticia G. Leon, Caterina Carmi, Andrea Ardizzoni

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 1, Pp 61-72 (2013)
Neoplasia, 15(1), 61-72. Elsevier Inc.
Europe PubMed Central
Galvani, E, Giovannetti, E, Saccani, F, Cavazzoni, A, Leon, L G, Dekker, H, Alfieri, R, Carmi, C, Mor, M, Ardizzoni, A, Petronini, P G & Peters, G J 2013, ' Molecular Mechanisms Underlying the Antitumor Activity of 3-Aminopropanamide Irreversible Inhibitors of the Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer ', Neoplasia, vol. 15, no. 1, pp. 61-72 . https://doi.org/10.1593/neo.121434

Overcoming the emergence of acquired resistance to clinically approved epidermal growth factor receptor (EGFR) inhibitors is a major challenge in the treatment of advanced non-small cell lung cancer (NSCLC). The aimof this study was to investigate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3a42a5c92cfa056120685b640acd22
http://www.sciencedirect.com/science/article/pii/S1476558613801261