Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Francesca R Dejure"'
Autor:
Salvatore Benfatto, Özdemirhan Serçin, Francesca R. Dejure, Amir Abdollahi, Frank T. Zenke, Balca R. Mardin
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-22 (2021)
Abstract Background Synthetic lethality describes a genetic interaction between two perturbations, leading to cell death, whereas neither event alone has a significant effect on cell viability. This concept can be exploited to specifically target tum
Externí odkaz:
https://doaj.org/article/ff8c47867c32418e8423c70dbf2b4ab1
Autor:
Martin Eilers, Stefanie Schmidt, Y. Schurr, Armin Wiegering, G. Schwarz, Sarah Denk, C. Armendariz, Francesca R Dejure, F. Schote, Markus E. Diefenbacher
Publikováno v:
International Journal of Colorectal Disease
Background Deregulated expression of MYC is a driver of colorectal carcinogenesis, suggesting that decreasing MYC expression may have significant therapeutic value. CIP2A is an oncogenic factor that regulates MYC expression. CIP2A is overexpressed in
Autor:
Jan H. Reiling, Tatiana I. Ignashkova, Stefan Wölfl, Hamed Alborzinia, Mathieu Gendarme, Francesca R. Dejure, Ralph K. Lindemann, Jannick Theobald
Publikováno v:
Communications Biology, Vol 1, Iss 1, Pp 1-15 (2018)
Communications Biology
Communications Biology
Cytotoxic activities of several Golgi-dispersing compounds including AMF-26/M-COPA, brefeldin A and golgicide A have previously been shown to induce autophagy or apoptosis. Here, we demonstrate that these Golgi disruptors also trigger ferroptosis, a
Publikováno v:
Oncotarget
Tumor cells typically enhance their metabolic capacity to sustain their higher rate of growth and proliferation. One way to elevate the nutrient intake into cancer cells is to increase the expression of genes encoding amino acid transporters, which m
Autor:
Stefanie Schmidt, Francesca R Dejure, F. Schote, Martin Eilers, Markus E. Diefenbacher, Y. Schurr, Armin Wiegering, Sarah Denk, G. Schwarz, C. Armendariz
Publikováno v:
Int J Colorectal Dis
Deregulated expression of MYC is a driver of colorectal carcinogenesis, suggesting that decreasing MYC expression may have significant therapeutic value. CIP2A is an oncogenic factor that regulates MYC expression. CIP2A is overexpressed in colorectal
Autor:
Jacqueline Kalb, Guido Mastrobuoni, Nadine Royla, Andreas Schlosser, Stefan Kempa, Elmar Wolf, Susanne Walz, Francesca R Dejure, Carsten P. Ade, Martin Eilers, Jens T. Vanselow, Steffi Herold
Publikováno v:
The EMBO Journal. 36:1854-1868
Deregulated expression of MYC enhances glutamine utilization and renders cell survival dependent on glutamine, inducing "glutamine addiction". Surprisingly, colon cancer cells that express high levels of MYC due to WNT pathway mutations are not gluta
Autor:
Nadine Vollmuth, Thomas F. Wulff, Werner Schmitz, Claudia Huber, Julian Fink, Wolfgang Eisenreich, Apoorva Baluapuri, Jürgen Seibel, Francesca R Dejure, Sudha Janaki-Raman, Karthika Rajeeve, Thomas Rudel, Elmar Wolf, Almut Schulze, Maximilian Schmalhofer
Obligate intracellular bacteria like Chlamydia trachomatis undergo a complex developmental cycle between infectious non-replicative (EBs) and non-infectious replicative (RBs) forms. EBs shortly after entering a host cell transform to RBs, a crucial p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37e39fe16a684b36cf002e26004bcc8
Autor:
Julian Fink, Rajeeve Sivadasan, Jürgen Seibel, Martin Eilers, Maximilian Schmalhofer, Sudha Janaki-Raman, Apoorva Baluapuri, Nadine Vollmuth, Thomas F. Wulff, Thomas Rudel, Werner Schmitz, Francesca R Dejure, Claudia Huber, Karthika Rajeeve, Elmar Wolf, Almut Schulze, Wolfgang Eisenreich
Publikováno v:
Nature microbiology
England
Rajeeve, K, Vollmuth, N, Janaki-Raman, S, Wulff, T F, Baluapuri, A, Dejure, F R, Huber, C, Fink, J, Schmalhofer, M, Schmitz, W, Sivadasan, R, Wolf, E, Eisenreich, W, Schulze, A, Seibel, J & Rudel, T 2020, ' Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis ', Nature Microbiology, vol. 5, no. 11, pp. 1390-1402 . https://doi.org/10.1038/s41564-020-0762-5
Nature Microbiology
England
Rajeeve, K, Vollmuth, N, Janaki-Raman, S, Wulff, T F, Baluapuri, A, Dejure, F R, Huber, C, Fink, J, Schmalhofer, M, Schmitz, W, Sivadasan, R, Wolf, E, Eisenreich, W, Schulze, A, Seibel, J & Rudel, T 2020, ' Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis ', Nature Microbiology, vol. 5, no. 11, pp. 1390-1402 . https://doi.org/10.1038/s41564-020-0762-5
Nature Microbiology
Obligate intracellular bacteria such as Chlamydia trachomatis undergo a complex developmental cycle between infectious, non-replicative elementary-body and non-infectious, replicative reticulate-body forms. Elementary bodies transform to reticulate b
Autor:
Julian Fink, Francesca R Dejure, Thomas Rudel, Martin Eilers, Sudha Janaki-Raman, Maximilian Schmalhofer, Rajeeve Sivadasan, Karthika Rajeeve, Elmar Wolf, Almut Schulze, Apoorva Baluapuri, Claudia Huber, Jürgen Seibel, Werner Schmitz, Wolfgang Eisenreich, Nadine Vollmuth, Thomas F. Wulff
Publikováno v:
Nature Microbiology. 6:533-533
Autor:
Francesca R Dejure, Martin Eilers
Publikováno v:
The EMBO journal. 36(23)
Transcription factors of the MYC family are deregulated in the majority of all human cancers. Oncogenic levels of MYC reprogram cellular metabolism, a hallmark of cancer development, to sustain the high rate of proliferation of cancer cells. Converse