Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Francesca Persichetti"'
Autor:
Damiano Mangoni, Alessandro Simi, Pierre Lau, Alexandros Armaos, Federico Ansaloni, Azzurra Codino, Devid Damiani, Lavinia Floreani, Valerio Di Carlo, Diego Vozzi, Francesca Persichetti, Claudio Santoro, Luca Pandolfini, Gian Gaetano Tartaglia, Remo Sanges, Stefano Gustincich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Long Interspersed Nuclear Elements-1s (L1s) are transposable elements that constitute most of the genome’s transcriptional output yet have still largely unknown functions. Here we show that L1s are required for proper mouse brain corticoge
Externí odkaz:
https://doaj.org/article/66f2f44858894eb082807efecd36e486
Autor:
Bianca Pierattini, Sabrina D’Agostino, Carlotta Bon, Omar Peruzzo, Andrej Alendar, Azzurra Codino, Gloria Ros, Francesca Persichetti, Remo Sanges, Piero Carninci, Claudio Santoro, Stefano Espinoza, Paola Valentini, Luca Pandolfini, Stefano Gustincich
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 402-414 (2023)
SINEUPs are natural and synthetic antisense long non-coding RNAs (lncRNAs) selectively enhancing target mRNAs translation by increasing their association with polysomes. This activity requires two RNA domains: an embedded inverted SINEB2 element acti
Externí odkaz:
https://doaj.org/article/439e7dc3410e4a769903132bc7c5d494
Autor:
Chiara Santulli, Carlotta Bon, Elena De Cecco, Marta Codrich, Joanna Narkiewicz, Pietro Parisse, Fabio Perissinotto, Claudio Santoro, Francesca Persichetti, Giuseppe Legname, Stefano Espinoza, Stefano Gustincich
Publikováno v:
Cell Death and Disease, Vol 13, Iss 12, Pp 1-12 (2022)
Abstract Parkinson’s disease (PD) presents the selective loss of A9 dopaminergic (DA) neurons of Substantia Nigra pars compacta (SNpc) and the presence of intracellular aggregates called Lewy bodies. α-synuclein (α-syn) species truncated at the c
Externí odkaz:
https://doaj.org/article/80bf628709704b4db31038a5f1387abc
Autor:
Casimiro Luca Gigliotti, Elena Boggio, Francesco Favero, Danny Incarnato, Claudio Santoro, Salvatore Oliviero, Josè Maria Rojo, Silvia Zucchelli, Francesca Persichetti, Gianluca Baldanzi, Umberto Dianzani, Davide Corà
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Costimulatory molecules of the CD28 family play a crucial role in the activation of immune responses in T lymphocytes, complementing and modulating signals originating from the T-cell receptor (TCR) complex. Although distinct functional roles have be
Externí odkaz:
https://doaj.org/article/55eb914dee7e467a8a6a4d3d915b6074
Autor:
Lavinia Floreani, Federico Ansaloni, Damiano Mangoni, Elena Agostoni, Remo Sanges, Francesca Persichetti, Stefano Gustincich
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2022)
Transposable elements (TEs) are mobile genetic elements that made up about half the human genome. Among them, the autonomous non-LTR retrotransposon long interspersed nuclear element-1 (L1) is the only currently active TE in mammals and covers about
Externí odkaz:
https://doaj.org/article/ed8c07c6de2d44b598cd98cb2cd9b0f1
Autor:
Assunta Maria Casale, Francesco Liguori, Federico Ansaloni, Ugo Cappucci, Sara Finaurini, Giovanni Spirito, Francesca Persichetti, Remo Sanges, Stefano Gustincich, Lucia Piacentini
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103702- (2022)
Summary: Huntington's disease (HD) is an autosomal dominant disorder with progressive motor dysfunction and cognitive decline. The disease is caused by a CAG repeat expansion in the IT15 gene, which elongates a polyglutamine stretch of the HD protein
Externí odkaz:
https://doaj.org/article/547620f22e41412798599b25391b68df
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 14, Iss C, Pp 404-410 (2016)
Mammalian cells are an indispensable tool for the production of recombinant proteins in contexts where function depends on post-translational modifications. Among them, Chinese Hamster Ovary (CHO) cells are the primary factories for the production of
Externí odkaz:
https://doaj.org/article/d70de93169fb40c885c1f0f4d3b57d23
Autor:
Shobu Namura, Lorenz Hirt, Vanessa C. Wheeler, Kim M. McGinnis, Paige Hilditch-Maguire, Michael A. Moskowitz, Marcy E. MacDonald, Francesca Persichetti
Publikováno v:
Neurobiology of Disease, Vol 11, Iss 1, Pp 147-154 (2002)
Huntington's disease, with its dominant loss of striatal neurons, is triggered by an expanded glutamine tract in huntingtin. To investigate a proposed role for increased activation of the apoptotic cascade in mutant huntingtin's trigger mechanism, we
Externí odkaz:
https://doaj.org/article/97f8d2bb0483434288d7eb34b5d0e5ce
Autor:
Francesca Persichetti, Flavia Trettel, C.Chris Huang, Cornel Fraefel, H.T.Marc Timmers, James F. Gusella, Marcy E. MacDonald
Publikováno v:
Neurobiology of Disease, Vol 6, Iss 5, Pp 364-375 (1999)
Huntington's disease (HD) is caused by an expanded glutamine tract, which confers a novel aggregation-promoting property on the 350-kDa huntingtin protein. Using specific antibodies, we have probed the structure of the polyglutamine segment in mutant
Externí odkaz:
https://doaj.org/article/e5e1ccf6041545bda6b69946adea33a3
Autor:
Francesca Persichetti, Jayalakshmi Srinidhi, Lisa Kanaley, Pei Ge, Richard H. Myers, Kenneth D'Arrigo, Glenn T. Barnes, Marcy E. MacDonald, Jean-Paul Vonsattel, James F. Gusella, Edward D. Bird
Publikováno v:
Neurobiology of Disease, Vol 1, Iss 3, Pp 159-166 (1994)
CAG repeat expansion in the Huntington's disease gene (HD) was examined in postmortem brains from 310 clinically diagnosed and 15 ‘at risk’ individuals. Presence of an expanded CAG allele (>37 units) was the cause of the disorder in almost all ca
Externí odkaz:
https://doaj.org/article/e9c2806463654e5ca90173fec7656a03