Výsledky vyhledávání - "Francesca Palmas"

Akademický článek

The Intranigral Infusion of Human-Alpha Synuclein Oligomers Induces a Cognitive Impairment in Rats Associated with Changes in Neuronal Firing and Neuroinflammation in the Anterior Cingulate Cortex

Autor: Maria Francesca Palmas, Michela Etzi, Augusta Pisanu, Chiara Camoglio, Claudia Sagheddu, Michele Santoni, Maria Francesca Manchinu, Mauro Pala, Giuliana Fusco, Alfonso De Simone, Luca Picci, Giovanna Mulas, Saturnino Spiga, Maria Scherma, Paola Fadda, Marco Pistis, Nicola Simola, Ezio Carboni, Anna R. Carta

Publikováno v: Cells, Vol 11, Iss 17, p 2628 (2022)

Parkinson’s disease (PD) is a complex pathology causing a plethora of non-motor symptoms besides classical motor impairments, including cognitive disturbances. Recent studies in the PD human brain have reported microgliosis in limbic and neocortica

Externí odkaz: https://doaj.org/article/3eedc67be715406cbd276027691c9ffd

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Akademický článek

Repurposing Immunomodulatory Imide Drugs (IMiDs) in Neuropsychiatric and Neurodegenerative Disorders

Autor: Yoo Jin Jung, David Tweedie, Michael T. Scerba, Dong Seok Kim, Maria Francesca Palmas, Augusta Pisanu, Anna R. Carta, Nigel H. Greig

Publikováno v: Frontiers in Neuroscience, Vol 15 (2021)

Neuroinflammation represents a common trait in the pathology and progression of the major psychiatric and neurodegenerative disorders. Neuropsychiatric disorders have emerged as a global crisis, affecting 1 in 4 people, while neurological disorders a

Externí odkaz: https://doaj.org/article/9646c29fec9d42168ac9907f0232eade

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Nanocrystals as an effective strategy to improve Pomalidomide bioavailability in rodent

Autor: Maria Cristina Cardia, Maria Francesca Palmas, Luca Casula, Augusta Pisanu, Salvatore Marceddu, Donatella Valenti, Chiara Sinico, Elena Pini, Michael T. Scerba, David Tweedie, Nigel H. Greig, Anna Rosa Carta, Francesco Lai

Publikováno v: International journal of pharmaceutics. 625

Pomalidomide (POM) is an FDA-approved immunomodulatory imide drug (IMiDs) an it is effectively used in the treatment of multiple myeloma. IMiDs are analogs of the drug thalidomide and they have been repurposed for the treatment of several diseases su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd4ed070d9fe29058311057be5c7789
https://pubmed.ncbi.nlm.nih.gov/35932932

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Modeling Parkinson’s Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers

Autor: Ignazia Mocci, Elzbieta Janda, Anna R. Carta, Saturnino Spiga, Alfonso De Simone, Anna Ena, Maria Antonietta Casu, Maria Scherma, Augusta Pisanu, Ezio Carboni, Giovanna Mulas, Maria Francesca Palmas, Giuliana Fusco, Paola Fadda, Laura Boi, Valentina Satta

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 8535, p 8535 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 22
International journal of molecular sciences
21 (2020): 1–25. doi:10.3390/ijms21228535
info:cnr-pdr/source/autori:Boi L.; Pisanu A.; Palmas M.F.; Fusco G.; Carboni E.; Casu M.A.; Satta V.; Scherma M.; Janda E.; Mocci I.; Mulas G.; Ena A.; Spiga S.; Fadda P.; De Simone A.; Carta A.R./titolo:Modeling Parkinson's disease neuropathology and symptoms by intranigral inoculation of preformed human ?-synuclein oligomers/doi:10.3390%2Fijms21228535/rivista:International journal of molecular sciences (Print)/anno:2020/pagina_da:1/pagina_a:25/intervallo_pagine:1–25/volume:21

The accumulation of aggregated &alpha
synuclein (&alpha
Syn) is a hallmark of Parkinson&rsquo
s disease (PD). Current evidence indicates that small soluble &alpha
Syn oligomers (&alpha
SynOs) are the most toxic species among

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba27676096dba207ee0feca4bcf4ed2b
https://www.mdpi.com/1422-0067/21/22/8535

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Advances in modelling alpha-synuclein-induced Parkinson's diseases in rodents: Virus-based models versus inoculation of exogenous preformed toxic species

Autor: Augusta Pisanu, Anna R. Carta, Maria Francesca Palmas, Ezio Carboni, Laura Boi, A. De Simone

Publikováno v: Journal of neuroscience methods. 338

Aggregates of alpha-synuclein (αSyn) have been described in Parkinson's disease (PD) patients, and recent evidence has suggested that the most toxic αSyn species in PD are small soluble aggregates including oligomers, prefibrils, protofibrils. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7760f788b84e45f745e4ea06795345fc
https://pubmed.ncbi.nlm.nih.gov/32173400

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