The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions

Autor: Alon Herschhorn, Christopher Gu, Francesca Moraca, Xiaochu Ma, Mark Farrell, Amos B. Smith, Marie Pancera, Peter D. Kwong, Arne Schön, Ernesto Freire, Cameron Abrams, Scott C. Blanchard, Walther Mothes, Joseph G. Sodroski

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

Binding of viral envelope glycoproteins (Env) to the host cell CD4 receptor mediates HIV-1 entry. Here, the authors develop compounds that inhibit the CD4-induced conformational changes in Env and show that the gp120 β20-β21 element is a key regula

Externí odkaz: https://doaj.org/article/b36161e14e3f46feaa6eadd812d25c74

Publisher Correction: The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions

Autor: Alon Herschhorn, Christopher Gu, Francesca Moraca, Xiaochu Ma, Mark Farrell, Amos B. Smith, Marie Pancera, Peter D. Kwong, Arne Schön, Ernesto Freire, Cameron Abrams, Scott C. Blanchard, Walther Mothes, Joseph G. Sodroski

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)

The original version of this Article contained an error in the spelling of the author Amos B. Smith, III, which was incorrectly given as Amos B. SmithIII. This has now been corrected in both the PDF and HTML versions of the Article.

Externí odkaz: https://doaj.org/article/674c8bbdf17a40eb8d6bf661351a14be

Exploring the Activity Profile of TbrPDEB1 and hPDE4 Inhibitors Using Free Energy Perturbation

Autor: Lorena Zara, Francesca Moraca, Jacqueline E. Van Muijlwijk-Koezen, Barbara Zarzycka, Robert Abel, Iwan J. P. de Esch

Publikováno v: Zara, L, Moraca, F, van Muijlwijk-Koezen, J E, Zarzycka, B, Abel, R & de Esch, I 2022, ' Exploring the Activity Profile of TbrPDEB1 and hPDE4 Inhibitors Using Free Energy Perturbation ', ACS medicinal chemistry letters, vol. 13, no. 6, pp. 904-910 . https://doi.org/10.1021/acsmedchemlett.1c00690
ACS medicinal chemistry letters, 13(6), 904-910. American Chemical Society

Human African trypanosomiasis (HAT) is a neglected tropical disease caused by the parasite Trypanosoma brucei (T.b.). A validated target for the treatment of HAT is the parasitic T.b. cyclic nucleotide phosphodiesterase B1 (TbrPDEB1). Although nanomo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169f6e4126d9fe4e4ad61cd7da017d9e
https://research.vu.nl/en/publications/bdeb587f-43c0-41aa-b2fc-64f344fa2af7

Identification of gp120 Residue His105 as a Novel Target for HIV-1 Neutralization by Small-Molecule CD4-Mimics

Autor: Mohammadjavad Mohammadi, Junhua Chen, Joseph Sodroski, Wayne A. Hendrickson, Amos B. Smith, Shuaiyi Liang, Saumya Anang, Cameron F. Abrams, Christopher J. Fritschi, Francesca Moraca, Navid Madani

Publikováno v: ACS Med Chem Lett

[Image: see text] The design and synthesis of butyl chain derivatives at the indane ring 3-position of our lead CD4-mimetic compound BNM-III-170 that inhibits human immunodeficiency virus (HIV-1) infection are reported. Optimization efforts were guid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5772e7d82d42e6514626268a023c45
https://doi.org/10.1021/acsmedchemlett.1c00437

Macrocyclic Peptides that Selectively Inhibit the

Autor: Hao, Zhang, Hao-Chi, Hsu, Shoshanna C, Kahne, Ryoma, Hara, Wenhu, Zhan, Xiuju, Jiang, Kristin, Burns-Huang, Tierra, Ouellette, Toshihiro, Imaeda, Rei, Okamoto, Masanori, Kawasaki, Mayako, Michino, Tzu-Tshin, Wong, Akinori, Toita, Takafumi, Yukawa, Francesca, Moraca, Jeremie, Vendome, Priya, Saha, Kenjiro, Sato, Kazuyoshi, Aso, John, Ginn, Peter T, Meinke, Michael, Foley, Carl F, Nathan, K Heran, Darwin, Huilin, Li, Gang, Lin

Publikováno v: J Med Chem

Treatment of tuberculosis (TB) currently takes at least 6 months. Latent Mycobacterium tuberculosis (Mtb) are phenotypically tolerant to most anti-TB drugs. A key hypothesis is that drugs that kill non-replicating (NR) Mtb may shorten treatment when

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a9ddc822052e96f40a4907042b230377
https://pubmed.ncbi.nlm.nih.gov/33949190