Výsledky vyhledávání - "Francesca Migheli"

Akademický článek

Efficacy and Feasibility of the Epithelial Cell Adhesion Molecule (EpCAM) Immunomagnetic Cell Sorter for Studies of DNA Methylation in Colorectal Cancer

Autor: Alessandra Failli, Annalisa Legitimo, Francesca Migheli, Fabio Coppedè, John C. Mathers, Roberto Spisni, Paolo Miccoli, Lucia Migliore, Rita Consolini

Publikováno v: International Journal of Molecular Sciences, Vol 15, Iss 1, Pp 44-57 (2013)

The aim of this work was to assess the impact on measurements of methylation of a panel of four cancer gene promoters of purifying tumor cells from colorectal tissue samples using the epithelial cell adhesion molecule (EpCAM)-immunomagnetic cell enri

Externí odkaz: https://doaj.org/article/6f29f6a6d3d54cb987f6810fab9a64e9

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Akademický článek

Susceptibility to Aneuploidy in Young Mothers of Down Syndrome Children

Autor: Lucia Migliore, Francesca Migheli, Fabio Coppedè

Publikováno v: The Scientific World Journal, Vol 9, Pp 1052-1060 (2009)

We recently observed an increased frequency of binucleated micronucleated lymphocytes in women who had a Down syndrome (DS) child before 35 years of age and the fluorescence in situ hybridization analysis revealed that micronuclei were mainly origina

Externí odkaz: https://doaj.org/article/320f09a359c340e0bf2532b6b22a4d54

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Akademický článek

Comparison study of MS-HRM and pyrosequencing techniques for quantification of APC and CDKN2A gene methylation.

Autor: Francesca Migheli, Andrea Stoccoro, Fabio Coppedè, Wan Adnan Wan Omar, Alessandra Failli, Rita Consolini, Massimo Seccia, Roberto Spisni, Paolo Miccoli, John C Mathers, Lucia Migliore

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e52501 (2013)

There is increasing interest in the development of cost-effective techniques for the quantification of DNA methylation biomarkers. We analyzed 90 samples of surgically resected colorectal cancer tissues for APC and CDKN2A promoter methylation using m

Externí odkaz: https://doaj.org/article/5c4a81471e914b33a87f1a27b87743bb

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Gene promoter methylation in colorectal cancer and healthy adjacent mucosa specimens

Autor: Francesca Migheli, Gabriella Fontanini, Angela Lopomo, Massimo Seccia, Adele Servadio, Annalisa Legitimo, Elisa Sensi, Rita Consolini, Massimo Chiarugi, Fabio Coppedè, Giuseppe Zocco, Lucia Migliore, Alessandra Failli, Roberto Spisni

Publikováno v: Epigenetics. 9:621-633

We evaluated the promoter methylation levels of the APC, MGMT, hMLH1, RASSF1A and CDKN2A genes in 107 colorectal cancer (CRC) samples and 80 healthy adjacent tissues. We searched for correlation with both physical and pathological features, polymorph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c500e5de034aead21fa57ab4d0a97d
https://doi.org/10.4161/epi.27956

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Efficacy and Feasibility of the Epithelial Cell Adhesion Molecule (EpCAM) Immunomagnetic Cell Sorter for Studies of DNA Methylation in Colorectal Cancer

Autor: John C. Mathers, Lucia Migliore, Paolo Miccoli, Alessandra Failli, Rita Consolini, Annalisa Legitimo, Roberto Spisni, Francesca Migheli, Fabio Coppedè

Publikováno v: International Journal of Molecular Sciences, Vol 15, Iss 1, Pp 44-57 (2013)
International Journal of Molecular Sciences
Volume 15
Issue 1
Pages 44-57

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6179232215e8eec9765727e5b8e3a22f
http://www.mdpi.com/1422-0067/15/1/44

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DNMT3B Promoter Polymorphisms and Risk of Late Onset Alzheimer’s Disease

Autor: Angela Dardano, Fabio Coppedè, Fabio Monzani, Gabriele Siciliano, Francesca Migheli, Benedetta Nacmias, Annalisa Lo Gerfo, Lucia Migliore, Michelangelo Mancuso, Sandro Sorbi, Maria Teresa Zitarosa, Silvia Bagnoli

Publikováno v: Current Alzheimer Research. 9:550-554

The vast majority of Alzheimer’s disease (AD) are late-onset forms (LOAD) likely due to the contribution of genetic, environmental, and stochastic factors, superimposed on a physiologically age-related decline of neuronal functions. Increasing evid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c0726ecb5a244d7bcc38e6de0d78f4
https://doi.org/10.2174/156720512800618062

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Association of maternal polymorphisms in folate metabolizing genes with chromosome damage and risk of Down syndrome offspring

Autor: Ivana Antonucci, Giandomenico Palka, Gabriele Siciliano, Lucia Migliore, Stefania Bargagna, Liborio Stuppia, Fabio Coppedè, Francesca Migheli

Publikováno v: Neuroscience Letters. 449:15-19

We analyzed the role of six common polymorphisms in folate metabolizing genes as possible risk factors for having a child with Down syndrome (DS) in 94 Italian mothers of a DS child (MDS) and 113 matched control mothers, both aged less than 35 years

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f485da2626f61d45a2d948b5f0d0a0
https://doi.org/10.1016/j.neulet.2008.10.074

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Epigenetic perturbations in the context of the multi-hit hypothesis of carcinogenesis

Autor: Lucia Migliore, Francesca Migheli

Publikováno v: Molecular mechanisms and physiology of disease ISBN: 9781493907052

Since 1950, a large number of models tried to represent the tumorigenesis process; numerous theories have overlapped and have been changed or improved along the way. Recently the significant role of epigenetics has emerged. These dynamic modification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ed2c6e4cd7fe635feba1de2519f0bb
http://hdl.handle.net/11568/899484

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