Prenatal expression of d‑aspartate oxidase causes early cerebral d‑aspartate depletion and influences brain morphology and cognitive functions at adulthood

Autor: Tommaso Nuzzo, Hiroshi Homma, Arianna De Rosa, Francesco Errico, Geppino Falco, Viviana Caputo, Masumi Katane, Alessandro Usiello, Yasuaki Saitoh, Francesca Mastrostefano, Andrea M. Isidori, Maria Egle De Stefano, Anna Di Maio, Pina Marotta

Publikováno v: Amino acids (Wien, Print) 52 (2020): 597–617. doi:10.1007/s00726-020-02839-y
info:cnr-pdr/source/autori:De Rosa A.; Mastrostefano F.; Di Maio A.; Nuzzo T.; Saitoh Y.; Katane M.; Isidori A.M.; Caputo V.; Marotta P.; Falco G.; De Stefano M.E.; Homma H.; Usiello A.; Errico F./titolo:Prenatal expression of d-aspartate oxidase causes early cerebral d-aspartate depletion and influences brain morphology and cognitive functions at adulthood/doi:10.1007%2Fs00726-020-02839-y/rivista:Amino acids (Wien, Print)/anno:2020/pagina_da:597/pagina_a:617/intervallo_pagine:597–617/volume:52

The free d-amino acid, d-aspartate, is abundant in the embryonic brain but significantly decreases after birth. Besides its intracellular occurrence, d-aspartate is also present at extracellular level and acts as an endogenous agonist for NMDA and mG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6785722a37849813b6e305458a422ab4
http://hdl.handle.net/11573/1396063