Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Francesca Martinato"'
Publikováno v:
PLoS ONE, Vol 3, Iss 11, p e3650 (2008)
The c-myc proto-oncogene is induced by mitogens and is a central regulator of cell growth and differentiation. The c-myc product, Myc, is a transcription factor that binds a multitude of genomic sites, estimated to be over 10-15% of all promoter regi
Externí odkaz:
https://doaj.org/article/1ce929c1bc004062b6d2a8a3c02061c2
A positive role for Myc in TGFβ-induced Snail transcription and epithelial-to-mesenchymal transition
Autor:
Giovanni Fagà, A.P. Smith, Bruno Amati, Ernesto Guccione, Francesca Martinato, Mirko Doni, Daniele Perna, Alessandro Verrecchia
Publikováno v:
Oncogene. 28:422-430
Myc and transforming growth factor-beta (TGFbeta) signaling are mutually antagonistic, that is Myc suppresses the activation of TGFbeta-induced genes, whereas TGFbeta represses c-myc transcription. Here, we report a positive role for Myc in the TGFbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3fc32d6af2f84fcfb97f764395bdb7
https://doi.org/10.1038/onc.2008.395
https://doi.org/10.1038/onc.2008.395
Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response
Autor:
Samantha Bennett, Alessandro Verrecchia, Nelofer Syed, Tim Crook, Paolo Nuciforo, John Lough, Maria Capra, Stefano Confalonieri, Massimo Squatrito, Chiara Luise, Sabine Mai, Milena Gasco, Matteo Cesaroni, Daniele Perna, Eugenio Scanziani, Bruno Amati, Chiara Gorrini, Francesco Marchesi, Domenico Sardella, Francesca Martinato, Landon Wark
Publikováno v:
Nature. 448:1063-1067
The acetyl-transferase Tip60 might influence tumorigenesis in multiple ways. First, Tip60 is a co-regulator of transcription factors that either promote or suppress tumorigenesis, such as Myc and p53. Second, Tip60 modulates DNA-damage response (DDR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d088f2354bb66b18f7813c10f70632a6
https://doi.org/10.1038/nature06055
https://doi.org/10.1038/nature06055
Autor:
Loris Bernard, Laura Tizzoni, Clara Nervi, Giuseppe Zardo, Bruno Amati, Valentina Dall' Olio, Lucilla Luzi, Francesca Martinato, Ernesto Guccione, Giacomo Finocchiaro
Publikováno v:
Nature Cell Biology. 8:764-770
Large-scale chromatin immunoprecipitation (ChIP) studies have been effective in unravelling the distribution of DNA-binding transcription factors along eukaryotic genomes, but specificity determinants remain elusive. Gene-regulatory regions display d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9635ca169b4da709a006b912bdec0c46
https://doi.org/10.1038/ncb1434
https://doi.org/10.1038/ncb1434
Autor:
Bernhard Lüscher, Ernesto Guccione, Fabio Casadio, Henning Schuchlautz, Bruno Amati, Francesca Martinato, Matteo Cesaroni, Christian Bassi
Publikováno v:
Nature. 449(7164)
Eukaryotic genomes are organized into active (euchromatic) and inactive (heterochromatic) chromatin domains. Post-translational modifications of histones (or 'marks') are key in defining these functional states, particularly in promoter regions. Mutu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fba3e1014fbaf95d3ebadeef8915246
https://pubmed.ncbi.nlm.nih.gov/17898714
https://pubmed.ncbi.nlm.nih.gov/17898714
Publikováno v:
PLoS ONE, Vol 3, Iss 11, p e3650 (2008)
PLoS ONE
PLoS ONE
The c-myc proto-oncogene is induced by mitogens and is a central regulator of cell growth and differentiation. The c-myc product, Myc, is a transcription factor that binds a multitude of genomic sites, estimated to be over 10-15% of all promoter regi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0a7c3464becdee6528a07cbf9ada4f
https://doi.org/10.1371/journal.pone.0003650
https://doi.org/10.1371/journal.pone.0003650