Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Francesca Maestrelli"'
Autor:
Giulia Nerli, Sandra Robla, Marta Bartalesi, Cristina Luceri, Mario D'Ambrosio, Noemi Csaba, Francesca Maestrelli
Publikováno v:
Carbohydrate Polymer Technologies and Applications, Vol 6, Iss , Pp 100332- (2023)
Crossing the Blood Brain Barrier constitutes a challenge in drug administration to the brain. In this context, nose-to-brain delivery is explored as an alternative route in the treatment of central nervous system disorders, and nanotechnology constit
Externí odkaz:
https://doaj.org/article/105062d25d8544138116ec24bf3f7684
Autor:
Francesca Maestrelli, Marzia Cirri, Natascia Mennini, Silvia Fiani, Beatrice Stoppacciaro, Paola Mura
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 633 (2024)
New oral tablets of nebivolol have been developed aiming to improve, by cyclodextrin (CD) complexation, its low solubility/dissolution properties—the main reason behind its poor/variable oral bioavailability. Phase-solubility studies, performed usi
Externí odkaz:
https://doaj.org/article/e417fe18ca5b48a58231e1c77318c1e1
Autor:
Ilaria Chiarugi, Diletta Biagi, Paolo Nencioni, Francesca Maestrelli, Maurizio Valleri, Paola Angela Mura
Publikováno v:
Pharmaceutics, Vol 16, Iss 2, p 165 (2024)
Orally disintegrating granules (ODGs) are a pharmaceutical form commonly used for the administration of NSAIDs because of their easy assumption and fast dispersion. The development of ODGs is not easy for drugs like dexketoprofen trometamol (DXKT), w
Externí odkaz:
https://doaj.org/article/3fead1d6c8f44e1daf879637aaeaa637
Autor:
Giulia Nerli, Lídia M. D. Gonçalves, Marzia Cirri, António J. Almeida, Francesca Maestrelli, Natascia Mennini, Paola A. Mura
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1305 (2023)
There is a serious need of pediatric drug formulations, whose lack causes the frequent use of extemporaneous preparations obtained from adult dosage forms, with consequent safety and quality risks. Oral solutions are the best choice for pediatric pat
Externí odkaz:
https://doaj.org/article/85b3c7ca18284c59ab484ea8e044bba2
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2567 (2022)
Nanogels combine the properties of hydrogels and nanocarrier systems, resulting in very effective drug delivery systems, including for cutaneous applications. Cyclodextrins (CDs) have been utilised to enhance the nanogels’ loading ability towards p
Externí odkaz:
https://doaj.org/article/47bd99645ba643b6b4a30f32e63ad74d
Publikováno v:
Marine Drugs, Vol 20, Iss 5, p 335 (2022)
Chitosan (CS) is a linear polysaccharide obtained by the deacetylation of chitin, which, after cellulose, is the second biopolymer most abundant in nature, being the primary component of the exoskeleton of crustaceans and insects. Since joining the p
Externí odkaz:
https://doaj.org/article/5c887f89978f45aca8b4c25705d36421
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 284 (2022)
Flufenamic acid (FFA) is a non-steroidal anti-inflammatory drug characterised by a low solubility and problems of variable dissolution rate and bio-inequivalence. Different FFA batches, obtained by different suppliers, showed different powder charact
Externí odkaz:
https://doaj.org/article/ae158a51d9534d17b93364866b6420c3
Autor:
Marzia Cirri, Lavinia Maestrini, Francesca Maestrelli, Natascia Mennini, Paola Mura, Carla Ghelardini, Lorenzo Di Cesare Mannelli
Publikováno v:
Drug Delivery, Vol 25, Iss 1, Pp 1910-1921 (2018)
The hydrochlorothiazide (HCT) low solubility and permeability give rise to limited and variable bioavailability; its low stability makes it difficult to develop stable aqueous liquid formulations; its low dose makes the achievement of a homogeneous d
Externí odkaz:
https://doaj.org/article/b3cef52e65084eed9725b8d03ede50e8
Autor:
Marzia Cirri, Natascia Mennini, Giulia Nerli, Jessica Rubia, Enrico Casalone, Fabrizio Melani, Francesca Maestrelli, Paola Mura
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1923 (2021)
Cefixime (CEF) is a cephalosporin included in the WHO Model List of Essential Medicines for Children. Liquid formulations are considered the best choice for pediatric use, due to their great ease of administration and dose-adaptability. Owing to its
Externí odkaz:
https://doaj.org/article/8ff4b916504049389c223a66506e05f6
Autor:
Marzia Cirri, Francesca Maestrelli, Giulia Nerli, Natascia Mennini, Mario D’Ambrosio, Cristina Luceri, Paola Angela Mura
Publikováno v:
Pharmaceutics, Vol 13, Iss 7, p 969 (2021)
A thermosensitive, mucoadhesive in-situ gel for clonazepam (CLZ) intranasal delivery was developed, which aimed to achieve prolonged in-situ residence and controlled drug release, overcoming problems associated with its oral or parenteral administrat
Externí odkaz:
https://doaj.org/article/9d067e48e701435bb9a67ca219253f79