Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Francesca M Buffa"'
Autor:
Pahala Gedara Jayathilake, Pedro Victori, Clara E Pavillet, Chang Heon Lee, Dimitrios Voukantsis, Ana Miar, Anjali Arora, Adrian L Harris, Karl J Morten, Francesca M Buffa
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 3, p e1011944 (2024)
Deregulated metabolism is one of the hallmarks of cancer. It is well-known that tumour cells tend to metabolize glucose via glycolysis even when oxygen is available and mitochondrial respiration is functional. However, the lower energy efficiency of
Externí odkaz:
https://doaj.org/article/0eb01951447743aaa95598c797984cf8
Autor:
Nicholas GD Masca, Elizabeth MA Hensor, Victoria R Cornelius, Francesca M Buffa, Helen M Marriott, James M Eales, Michael P Messenger, Amy E Anderson, Chris Boot, Catey Bunce, Robert D Goldin, Jessica Harris, Rod F Hinchliffe, Hiba Junaid, Shaun Kingston, Carmen Martin-Ruiz, Christopher P Nelson, Janet Peacock, Paul T Seed, Bethany Shinkins, Karl J Staples, Jamie Toombs, Adam KA Wright, M Dawn Teare
Publikováno v:
eLife, Vol 4 (2015)
Lack of reproducibility is an ongoing problem in some areas of the biomedical sciences. Poor experimental design and a failure to engage with experienced statisticians at key stages in the design and analysis of experiments are two factors that contr
Externí odkaz:
https://doaj.org/article/a0d7e699f1c042edb9b4707dd4859347
Autor:
Charalampos P. Triantafyllidis, Alessandro Barberis, Fiona Hartley, Ana Miar Cuervo, Enio Gjerga, Philip Charlton, Linda van Bijsterveldt, Julio Saez Rodriguez, Francesca M. Buffa
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108291- (2023)
Summary: TP53, the Guardian of the Genome, is the most frequently mutated gene in human cancers and the functional characterization of its regulation is fundamental. To address this we employ two strategies: machine learning to predict the mutation s
Externí odkaz:
https://doaj.org/article/cfd2574106b94ea7810fc1afdf22fe39
Autor:
Christos E. Zois, Anne M. Hendriks, Syed Haider, Elisabete Pires, Esther Bridges, Dimitra Kalamida, Dimitrios Voukantsis, B. Christoffer Lagerholm, Rudolf S. N. Fehrmann, Wilfred F. A. den Dunnen, Andrei I. Tarasov, Otto Baba, John Morris, Francesca M. Buffa, James S. O. McCullagh, Mathilde Jalving, Adrian L. Harris
Publikováno v:
Cell Death and Disease, Vol 13, Iss 6, Pp 1-15 (2022)
Abstract Channelling of glucose via glycogen, known as the glycogen shunt, may play an important role in the metabolism of brain tumours, especially in hypoxic conditions. We aimed to dissect the role of glycogen degradation in glioblastoma (GBM) res
Externí odkaz:
https://doaj.org/article/b1ef617fb3104ffda4ec574e955e7b3f
Autor:
Shaliny Ramachandran, Tiffany S. Ma, Jon Griffin, Natalie Ng, Iosifina P. Foskolou, Ming-Shih Hwang, Pedro Victori, Wei-Chen Cheng, Francesca M. Buffa, Katarzyna B. Leszczynska, Sherif F. El-Khamisy, Natalia Gromak, Ester M. Hammond
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Hypoxia induces a change in transcriptional response in mammalian cells. Here the authors reveal a role for the RNA/DNA helicase Senataxin in protecting cells from DNA damage induced during transcription in hypoxia.
Externí odkaz:
https://doaj.org/article/53d171bea0d243d0a270df932d095042
Autor:
Ruben S. A. Goedegebuure, Esther A. Kleibeuker, Francesca M. Buffa, Kitty C. M. Castricum, Syed Haider, Iris A. Schulkens, Luuk ten Kroode, Jaap van den Berg, Maarten A. J. M. Jacobs, Anne-Marie van Berkel, Nicole C. T. van Grieken, Sarah Derks, Ben J. Slotman, Henk M. W. Verheul, Adrian L. Harris, Victor L. Thijssen
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-14 (2021)
Abstract Background Improvement of radiotherapy efficacy requires better insight in the dynamic responses that occur during irradiation. Here, we aimed to identify the molecular responses that are triggered during clinically applied fractionated irra
Externí odkaz:
https://doaj.org/article/0b5244fd5d7a4fdfa9186fcbf89b155f
Autor:
Rebecca Carter, Azadeh Cheraghchi-Bashi, Adam Westhorpe, Sheng Yu, Yasmin Shanneik, Elena Seraia, Djamila Ouaret, Yasuhiro Inoue, Catherine Koch, Jenny Wilding, Daniel Ebner, Anderson J. Ryan, Francesca M. Buffa, Ricky A. Sharma
Publikováno v:
Cancer Biology & Medicine, Vol 16, Iss 2, Pp 234-246 (2019)
Objective Patients with BRAF-mutant colorectal cancer (CRC) have a poor prognosis. Molecular status is not currently used to select which drug to use in combination with radiotherapy. Our aim was to identify drugs that radiosensitise CRC cells with k
Externí odkaz:
https://doaj.org/article/20f6deba4d8f477f8d7767514aae6c9b
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
miRNAs have emerged as regulators of diverse biological processes including cancer. Here the authors present an extended pan-cancer analysis of the miRNAs in 15 epithelial cancers; integrating methylation, transcriptomic and mutation data they reveal
Externí odkaz:
https://doaj.org/article/e52ce54346f6441bb9b0292d33a78d34
Autor:
Lingjian Yang, Darren Roberts, Mandeep Takhar, Nicholas Erho, Becky A.S. Bibby, Niluja Thiruthaneeswaran, Vinayak Bhandari, Wei-Chen Cheng, Syed Haider, Amy M.B. McCorry, Darragh McArt, Suneil Jain, Mohammed Alshalalfa, Ashley Ross, Edward Schaffer, Robert B. Den, R. Jeffrey Karnes, Eric Klein, Peter J. Hoskin, Stephen J. Freedland, Alastair D. Lamb, David E. Neal, Francesca M. Buffa, Robert G. Bristow, Paul C. Boutros, Elai Davicioni, Ananya Choudhury, Catharine M.L. West
Publikováno v:
EBioMedicine, Vol 31, Iss , Pp 182-189 (2018)
Background: Hypoxia is associated with a poor prognosis in prostate cancer. This work aimed to derive and validate a hypoxia-related mRNA signature for localized prostate cancer. Method: Hypoxia genes were identified in vitro via RNA-sequencing and c
Externí odkaz:
https://doaj.org/article/d7a28abff5b84473b106469a00a0c343
Publikováno v:
Molecular Cancer, Vol 16, Iss 1, Pp 1-19 (2017)
Abstract Background Hypoxia is a characteristic of breast tumours indicating poor prognosis. Based on the assumption that those genes which are up-regulated under hypoxia in cell-lines are expected to be predictors of poor prognosis in clinical data,
Externí odkaz:
https://doaj.org/article/607aeb687fcf4adb860c943f3cb51b92