Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Francesca M, Trovato"'
Autor:
Oliver D. Tavabie, Vishal C. Patel, Siamak Salehi, Marilena Stamouli, Francesca M. Trovato, Maria-Emanuela Maxan, Dhaarica Jeyanesan, Savannah Rivera, Salma Mujib, Ane Zamalloa, Eleanor Corcoran, Krishna Menon, Andreas Prachalias, Michael A. Heneghan, Kosh Agarwal, Mark J. W. McPhail, Varuna R. Aluvihare
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract As the global prevalence of chronic liver disease continues to rise, the need to determine which patients will develop end-stage liver disease and require liver transplantation is increasingly important. However, current prognostic models pe
Externí odkaz:
https://doaj.org/article/2a579e8547eb4da58013a9d7fc0825f7
Autor:
Tong Liu, Gang Wu, Cathrin L.C. Gudd, Francesca M. Trovato, Thomas Barbera, Yan Liu, Evangelos Triantafyllou, Mark J.W. McPhail, Mark R. Thursz, Wafa Khamri
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105336- (2024)
Summary: Background: Immune dysfunction contributes to a high rate of infection in patients with acute decompensation of cirrhosis. CD52 is a glycoprotein prominently expressed in lymphocytes. Immune regulation by CD52 may be involved in adaptive imm
Externí odkaz:
https://doaj.org/article/ba85926b98244f02a120cb26e57cd74a
Autor:
Francesca M. Trovato, MD, PhD, Florent Artru, MD, Rosa Miquel, MD, Tasneem Pirani, MD, Mark J.W. McPhail, MD, PhD
Publikováno v:
Critical Care Explorations, Vol 6, Iss 2, p e1048 (2024)
OBJECTIVES:. We aimed to assess the feasibility and reliability of sequential ultrasonographic and elastographic monitoring in acute liver failure (ALF). DESIGN:. Observational study. SETTING:. ALF is a rare, life-threatening disease that requires in
Externí odkaz:
https://doaj.org/article/afc568ca668345cda1a319b6e2830f5e
Autor:
Francesca M. Trovato, Salma Mujib, Ellen Jerome, Anna Cavazza, Phillip Morgan, John Smith, Maria Theresa Depante, Kevin O'Reilly, James Luxton, Tracey Mare, Salvatore Napoli, Mark JW. McPhail
Publikováno v:
Heliyon, Vol 8, Iss 6, Pp e09733- (2022)
Background: In Covid-19, profound systemic inflammatory responses are accompanied by both metabolic risk factors for severity and, separately, metabolic mechanisms have been shown to underly disease progression. It is unknown whether this reflects si
Externí odkaz:
https://doaj.org/article/ddba98825cd24d8e8b4f71123ef31c9b
Autor:
Maura A. Morrison, Florent Artru, Francesca M. Trovato, Evangelos Triantafyllou, Mark J. McPhail
Publikováno v:
Liver International.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4863ac3fe5dbf7c91b22e02922978c8
https://doi.org/10.1111/liv.15545
https://doi.org/10.1111/liv.15545
Autor:
Mark J. W. McPhail, Kosh Agarwal, Saima Ajaz, Salma F Mujib, Keshav K. Singh, Salvatore Napoli, Francesca M. Trovato
Publikováno v:
American Journal of Physiology-Cell Physiology
The COVID-19 pandemic has been the primary global health issue since its outbreak in December 2019. Patients with metabolic syndrome suffer from severe complications and a higher mortality rate due to severe acute respiratory syndrome coronavirus 2 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf847c064b321e3b77d27c50aa9660ed
https://doi.org/10.1152/ajpcell.00426.2020
https://doi.org/10.1152/ajpcell.00426.2020
Autor:
Cathrin Gudd, Sujit Mukherjee, Arjuna Singanayagam, Christopher J. Weston, Lucia A. Possamai, Fanny Lebossé, Rooshi Nathwani, Thomas A Barbera, Evangelos Triantafyllou, Sofia Azam, Charalambos G. Antoniades, Mark J. W. McPhail, Naveenta Kumar, Francesca M. Trovato, Marigona Krasniqi, Mark Thursz, Wafa Khamri, Tong Liu, C. Bernsmeier, Rocio Castro Seoane
ObjectiveIdentifying components of immuneparesis, a hallmark of chronic liver failure, is crucial for our understanding of complications in cirrhosis. Various suppressor CD4+T cells have been established as potent inhibitors of systemic immune activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10a00d06045cb18fd2d5514f5a01aa5
http://hdl.handle.net/10044/1/90704
http://hdl.handle.net/10044/1/90704
Autor:
Matthew K. Siggins, Wafa Khamri, Thomas O’Connor, Evangelos Triantafyllou, Mark Thursz, Marie-Anne Mawhin, Mark J. W. McPhail, Hannah C. Husbyn, Kevin J. Woollard, Sujit Mukherjee, Marina Botto, Cathrin Gudd, Robert D. Goldin, Christine Bernsmeier, Charalambos G. Antoniades, Lucia A. Possamai, Francesca M. Trovato, Julia Wendon, Hiromi Kudo
Publikováno v:
The Journal of Clinical Investigation
Patients with acute liver failure (ALF) have systemic innate immune suppression and increased susceptibility to infections. Programmed cell death 1 (PD-1) expression by macrophages has been associated with immune suppression during sepsis and cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57ff30014337155b03c74b6c2ac765a
https://doi.org/10.1172/jci140196
https://doi.org/10.1172/jci140196
Autor:
Wafa, Khamri, Cathrin, Gudd, Tong, Liu, Rooshi, Nathwani, Marigona, Krasniqi, Sofia, Azam, Thomas, Barbera, Francesca M, Trovato, Lucia, Possamai, Evangelos, Triantafyllou, Rocio Castro, Seoane, Fanny, Lebosse, Arjuna, Singanayagam, Naveenta, Kumar, Christine, Bernsmeier, Sujit, Mukherjee, Mark, McPhail, Chris J, Weston, Charalambos Gustav, Antoniades, Mark R, Thursz
Publikováno v:
Gut. 71(6)
Identifying components of immuneparesis, a hallmark of chronic liver failure, is crucial for our understanding of complications in cirrhosis. Various suppressor CD4Flow cytometry was used to determine the proportion and immunophenotype of CD4Patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3bd286e3b044d9dfe2758c154299378
https://pubmed.ncbi.nlm.nih.gov/34344786
https://pubmed.ncbi.nlm.nih.gov/34344786
Autor:
Nigel Heaton, Julia Wendon, Phillip E. Morgan, Salvatore Napoli, Rabiya Zia, Kate Wolfer, X. Huang, Francesca M. Trovato, Georg Auzinger, Evangelos Triantafyllou, Ian D. Wilson, Vishal C. Patel, Michael A. Heneghan, Marwa Elgosbi, Muireann Coen, Manuele Lucangeli, Hannah C. Husbyn, Mark J. W. McPhail, Rosa Miquel, Charalambos G. Antoniades
Publikováno v:
Hepatology (Baltimore, Md.)References. 74(2)
BACKGROUND & AIMS Acute-on-chronic liver failure (ACLF) is characterized by systemic inflammation, monocyte dysfunction, and susceptibility to infection. Lysophosphatidylcholines (LPCs) are immune-active lipids whose metabolic regulation and effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd812376d9cfdf5da2bf1758067507e5
https://pubmed.ncbi.nlm.nih.gov/33908067
https://pubmed.ncbi.nlm.nih.gov/33908067