Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Francesca Lodi"'
Autor:
Sarah Cappuyns, Gino Philips, Vincent Vandecaveye, Bram Boeckx, Rogier Schepers, Thomas Van Brussel, Ingrid Arijs, Aurelie Mechels, Ayse Bassez, Francesca Lodi, Joris Jaekers, Halit Topal, Baki Topal, Orian Bricard, Junbin Qian, Eric Van Cutsem, Chris Verslype, Diether Lambrechts, Jeroen Dekervel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The combination of atezolizumab plus bevacizumab (atezo/bev) has dramatically changed the treatment landscape of advanced HCC (aHCC), achieving durable responses in some patients. Using single-cell transcriptomics, we characterize the intra-
Externí odkaz:
https://doaj.org/article/db4b12030ddd4fd095ec4bcc29c92ddb
Autor:
Jelle Verhoeven, Kathryn A Jacobs, Francesca Rizzollo, Francesca Lodi, Yichao Hua, Joanna Poźniak, Adhithya Narayanan Srinivasan, Diede Houbaert, Gautam Shankar, Sanket More, Marco B Schaaf, Nikolina Dubroja Lakic, Maarten Ganne, Jochen Lamote, Johan Van Weyenbergh, Louis Boon, Oliver Bechter, Francesca Bosisio, Yasuo Uchiyama, Mathieu JM Bertrand, Jean Christophe Marine, Diether Lambrechts, Gabriele Bergers, Madhur Agrawal, Patrizia Agostinis
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp n/a-n/a (2023)
Abstract Tumor endothelial cells (TECs) actively repress inflammatory responses and maintain an immune‐excluded tumor phenotype. However, the molecular mechanisms that sustain TEC‐mediated immunosuppression remain largely elusive. Here, we show t
Externí odkaz:
https://doaj.org/article/bbcea8700d3946d0a54b3724c68d12c4
Autor:
Federica Fabro, Trisha V. Kers, Kate J. Feller, Cecile Beerens, Ioannis Ntafoulis, Ahmed Idbaih, Maite Verreault, Kate Connor, Archita Biswas, Manuela Salvucci, Jochen H. M. Prehn, Annette T. Byrne, Alice C. O’Farrell, Diether Lambrechts, Gonca Dilcan, Francesca Lodi, Ingrid Arijs, Andreas Kremer, Romain Tching Chi Yen, Miao-Ping Chien, Martine L. M. Lamfers, Sieger Leenstra
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15678 (2023)
Chemotherapy using temozolomide is the standard treatment for patients with glioblastoma. Despite treatment, prognosis is still poor largely due to the emergence of temozolomide resistance. This resistance is closely linked to the widely recognized i
Externí odkaz:
https://doaj.org/article/8271d679ac384d7fb2b4f54037633904
Autor:
Sweta Parik, Juan Fernández-García, Francesca Lodi, Karen De Vlaminck, Marleen Derweduwe, Steven De Vleeschouwer, Raf Sciot, Wietse Geens, Linqian Weng, Francesca Maria Bosisio, Gabriele Bergers, Johnny Duerinck, Frederick De Smet, Diether Lambrechts, Jo A. Van Ginderachter, Sarah-Maria Fendt
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Glioblastoma is a highly lethal grade of astrocytoma with very low median survival. Despite extensive efforts, there is still a lack of alternatives that might improve these prospects. We uncovered that the chemotherapeutic agent temozolomide impinge
Externí odkaz:
https://doaj.org/article/9b367757c6e54473af57787cad0920a8
Autor:
Archita Biswas, Manuela Salvucci, Kate Connor, Heiko Düssmann, Steven Carberry, Michael Fichtner, Ellen King, Brona Murphy, A.C O’Farrell, Jane Cryan, Alan Beausang, Josephine Heffernan, Mattia Cremona, Bryan T. Hennessy, James Clerkin, Kieron J. Sweeney, Steve MacNally, F Brett, P O’Halloran, Orna Bacon, Simon Furney, Maite Verreault, Emie Quissac, Franck Bielle, Mohammed H Ahmed, Ahmed Idbaih, Sieger Leenstra, Ioannis Ntafoulis, Federica Fabro, Martine Lamfers, Anna Golebiewska, Frank Hertel, Simone P Niclou, Romain Tching Chi Yen, Andreas Kremer, Gonca Dilcan, Francesca Lodi, Ingrid Arijs, Diether Lambrechts, Manasa Kalya P, Alexander Kel, Annette T Byrne, Jochen H.M Prehn
Publikováno v:
Journal of Neuro-Oncology.
Background Glioblastoma (GBM) is an aggressive brain cancer that typically results in death in the first 15 months after diagnosis. There have been limited advances in finding new treatments for GBM. In this study, we investigated molecular differenc
Autor:
Francesca Lodi, Michelangelo Certo, Hagar Elkafrawy, Weixing Li, Hong A. Vu, Konstantin Gilbo, Li Su, Ian L. Pegg, Tobias Weiss, Marcel Bühler, Michael Weller, Charles Yeh, Jacob E. Corn, Kwon-Sik Park, Jeong-Hun Ko, Jacques Behmoaras, Claudio Mauro, Diether Lambrechts, Adonia E. Papathanassiu
The present study explores the role of the cytosolic branched chain amino acid aminotransferase (BCAT1) in CD8+T cell activation, in general, and tumor immunity, in particular, and identifies a non-canonical function of the protein in iron homeostasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41992241eae6ac3447e68d05b16c9b4b
https://doi.org/10.1101/2023.02.25.530034
https://doi.org/10.1101/2023.02.25.530034
Autor:
Tina Laga, Pieter Busschaert, Siel Olbrecht, Liselore Loverix, Francesca Lodi, Thaïs Baert, Toon Van Gorp, Anne-Sophie Van Rompuy, Ignace Vergote, Diether Lambrechts, Els Van Nieuwenhuysen
Publikováno v:
Translational research/biomarkers.
Autor:
Francesca Lodi, Sam Vanmassenhove, Elena Donders, Pierre Van Mol, Amelie Franken, Sarah Cappuyns, Ayse Bassez, Siel Olbrecht, Liselore Loverix, Michel Bila, Hanne Vos, Joanna Pozniak, Kevin Punie, Diether Lambrechts
Publikováno v:
Cancer Research. 83:5785-5785
The tumor microenvironment (TME) shapes response to immune checkpoint blockade (ICB). Several pan-cancer single-cell RNA-sequencing (scRNA-seq) analyses have reported how TME heterogeneity profoundly differs between cancer types. These studies mainly
Autor:
Olivier De Wever, Francesca Maria Bosisio, Ana Rita Pombo Antunes, Signe Schmidt Kjølner Hansen, Frederik De Smet, Raf Sciot, Asier Antoranz, Bart Neyns, Niels Vandamme, Diether Lambrechts, Roosmarijn E. Vandenbroucke, Francesca Lodi, Johnny Duerinck, Karen De Vlaminck, Jo A. Van Ginderachter, Liesbet Martens, Luc Bouwens, Koen Van der Borght, M. Verfaillie, Conny Gysemans, Daliya Kancheva, Martin Guilliams, Yvan Saeys, Kiavash Movahedi, Isabelle Scheyltjens, Julie Messiaen, Hannah Van Hove, Steven De Vleeschouwer
Publikováno v:
Nature Neuroscience
Glioblastomas are aggressive primary brain cancers that recur as therapy-resistant tumors. Myeloid cells control glioblastoma malignancy, but their dynamics during disease progression remain poorly understood. Here, we employed single-cell RNA sequen
Autor:
Philip J. O’Halloran, Diether Lambrechts, Patrick Dicker, Monika A. Jarzabek, Francesca Lodi, Kate Connor, Jann N. Sarkaria, David W. Murray, Kieron White, Brian MacCarthy, Kieron J. Sweeney, Liam Shiels, Nhan L. Tran, Raymond M. Schiffelers, Annette T. Byrne, Marc Symons
Publikováno v:
Cancers
Cancers, Vol 12, Iss 3531, p 3531 (2020)
Volume 12
Issue 12
Cancers, Vol 12, Iss 3531, p 3531 (2020)
Volume 12
Issue 12
Glioblastoma (GBM), a highly invasive and vascular malignancy is shown to rapidly develop resistance and evolve to a more invasive phenotype following bevacizumab (Bev) therapy. Rho Guanine Nucleotide Exchange Factor proteins (RhoGEFs) are mediators