Výsledky vyhledávání - "Francesca Langone"

Akademický článek

Retargeted and Multi-cytokine-Armed Herpes Virus Is a Potent Cancer Endovaccine for Local and Systemic Anti-tumor Treatment

Autor: Maria De Lucia, Gabriella Cotugno, Veronica Bignone, Irene Garzia, Linda Nocchi, Francesca Langone, Biljana Petrovic, Emanuele Sasso, Simona Pepe, Guendalina Froechlich, Chiara Gentile, Nicola Zambrano, Gabriella Campadelli-Fiume, Alfredo Nicosia, Elisa Scarselli, Anna Morena D’Alise

Publikováno v: Molecular Therapy: Oncolytics, Vol 19, Iss , Pp 253-264 (2020)

Oncolytic viruses (OVs) are novel anti-tumor agents with the ability to selectively infect and kill tumor cells while sparing normal tissue. Beyond tumor cytolysis, OVs are capable of priming an anti-tumor immune response via lysis and cross-presenta

Externí odkaz: https://doaj.org/article/b42887904459445c8ca4a40719963797

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Akademický článek

Adenoviral vaccine targeting multiple neoantigens as strategy to eradicate large tumors combined with checkpoint blockade

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Vaccination against neo-antigens has resulted in an effective antitumor response in several models. Here, the authors show that delivery of larger sets of neo-antigens using an adenovirus-based vaccination platform, results in much better tumor prote

Externí odkaz: https://doaj.org/article/db93e80d193c417e9e00b2880fe30cbc

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Akademický článek

VENUS, a Novel Selection Approach to Improve the Accuracy of Neoantigens’ Prediction

Autor: Guido Leoni, Anna Morena D’Alise, Fabio Giovanni Tucci, Elisa Micarelli, Irene Garzia, Maria De Lucia, Francesca Langone, Linda Nocchi, Gabriella Cotugno, Rosa Bartolomeo, Giuseppina Romano, Simona Allocca, Fulvia Troise, Alfredo Nicosia, Armin Lahm, Elisa Scarselli

Publikováno v: Vaccines, Vol 9, Iss 8, p 880 (2021)

Neoantigens are tumor-specific antigens able to induce T-cell responses, generated by mutations in protein-coding regions of expressed genes. Previous studies demonstrated that only a limited subset of mutations generates neoantigens in microsatellit

Externí odkaz: https://doaj.org/article/70ac80030d6e4d77a7634edce691717b

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Akademický článek

The SH2 Domain Interaction Landscape

Autor: Michele Tinti, Lars Kiemer, Stefano Costa, Martin L. Miller, Francesca Sacco, Jesper V. Olsen, Martina Carducci, Serena Paoluzi, Francesca Langone, Christopher T. Workman, Nikolaj Blom, Kazuya Machida, Christopher M. Thompson, Mike Schutkowski, Søren Brunak, Matthias Mann, Bruce J. Mayer, Luisa Castagnoli, Gianni Cesareni

Publikováno v: Cell Reports, Vol 3, Iss 4, Pp 1293-1305 (2013)

Members of the SH2 domain family modulate signal transduction by binding to short peptides containing phosphorylated tyrosines. Each domain displays a distinct preference for the sequence context of the phosphorylated residue. We have developed a hig

Externí odkaz: https://doaj.org/article/88826bc6e1fb41f282c010ce5f6c4d64

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Akademický článek

Metformin protects skeletal muscle from cardiotoxin induced degeneration.

Autor: Francesca Langone, Stefano Cannata, Claudia Fuoco, Daniele Lettieri Barbato, Stefano Testa, Aurelio Pio Nardozza, Maria Rosa Ciriolo, Luisa Castagnoli, Cesare Gargioli, Gianni Cesareni

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e114018 (2014)

The skeletal muscle tissue has a remarkable capacity to regenerate upon injury. Recent studies have suggested that this regenerative process is improved when AMPK is activated. In the muscle of young and old mice a low calorie diet, which activates A

Externí odkaz: https://doaj.org/article/3c2bca866fca4f7b87dfafdf5f78f7a3

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Adenoviral-based vaccine promotes neoantigen-specific CD8

Publikováno v: Sci Transl Med

Upon chronic antigen exposure, CD8(+) T cells become exhausted, acquiring a dysfunctional state correlated with the inability to control infection or tumor progression. In contrast, stem-like CD8(+) T progenitors maintain the ability to promote and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a58e15fa34d23ff89b7917f31f6ccee
https://pubmed.ncbi.nlm.nih.gov/35947675

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Retargeted and Multi-cytokine-Armed Herpes Virus Is a Potent Cancer Endovaccine for Local and Systemic Anti-tumor Treatment

Autor: Gabriella Campadelli-Fiume, Gabriella Cotugno, Irene Garzia, Alfredo Nicosia, Maria De Lucia, Francesca Langone, Emanuele Sasso, Guendalina Froechlich, Chiara Gentile, Biljana Petrovic, Anna Morena D'Alise, Nicola Zambrano, Simona Pepe, Veronica Bignone, Elisa Scarselli, Linda Nocchi

Publikováno v: Molecular Therapy: Oncolytics, Vol 19, Iss, Pp 253-264 (2020)
Molecular Therapy Oncolytics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e0ff896c974912e12b86497d6ded08
http://www.sciencedirect.com/science/article/pii/S2372770520301571

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