Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Francesca La Carpia"'
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Loss of humoral tolerance to red blood cells (RBCs) can lead to autoimmune hemolytic anemia (AIHA), a severe, and sometimes fatal disease. Patients with AIHA present with pallor, fatigue, decreased hematocrit, and splenomegaly. While secondary AIHA i
Externí odkaz:
https://doaj.org/article/f4eb8fe2dcc7496e83c3f3ff8010c4d7
Autor:
Sahar Gelfman, Quanli Wang, K. Melodi McSweeney, Zhong Ren, Francesca La Carpia, Matt Halvorsen, Kelly Schoch, Fanni Ratzon, Erin L. Heinzen, Michael J. Boland, Slavé Petrovski, David B. Goldstein
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
While non-coding synonymous and intronic variants are often not under strong selective constraint, they can be pathogenic through affecting splicing or transcription. Here, the authors develop a score that uses sequence context alterations to predict
Externí odkaz:
https://doaj.org/article/416a7ceb757b4b1cb818a138ccea63b5
Autor:
Eldad A. Hod, Gary M. Brittenham, Zachary C. Bitan, Yona Feit, Jordan I. Gaelen, Francesca La Carpia, Luke A. Sandoval, Alice T. Zhou, Mark Soffing, Akiva Mintz, Joseph Schwartz, Connie Eng, Marta Scotto, Elise Caccappolo, Christian Habeck, Yaakov Stern, Donald J. McMahon, Debra A. Kessler, Beth H. Shaz, Richard O. Francis, Steven L. Spitalnik
Publikováno v:
Blood. 140:2730-2739
Although altruistic regular blood donors are vital for the blood supply, many become iron deficient from donation-induced iron loss. The effects of blood donation–induced iron deficiency on red cell transfusion quality or donor cognition are unknow
Autor:
Chiara Moriconi, Monika Dzieciatkowska, Micaela Roy, Angelo D'Alessandro, Philippe Roingeard, June Young Lee, David R. Gibb, Maria Tredicine, Marlon A. McGill, Annie Qiu, Francesca La Carpia, Richard O. Francis, Eldad A. Hod, Tiffany Thomas, Martin Picard, Imo J. Akpan, Chance John Luckey, James C. Zimring, Steven L. Spitalnik, Krystalyn E. Hudson
Publikováno v:
British Journal of Haematology. 198:574-586
Sickle cell disease (SCD) is an inherited blood disorder characterized by sickled red blood cells (RBCs), which are more sensitive to haemolysis and can contribute to disease pathophysiology. Although treatment of SCD can include RBC transfusion, pat
Autor:
Micaela Kalani Roy, Francesca La Carpia, Francesca Cendali, Sebastian Fernando, Chiara Moriconi, Boguslaw S. Wojczyk, Lin Wang, Travis Nemkov, Eldad A. Hod, Angelo D’Alessandro
Publikováno v:
J Proteome Res
Investigating the metabolic effects of radiation is critical to understand the impact of radiotherapy, space travel, and exposure to environmental radiation. In patients undergoing hemopoietic stem cell transplantation, iron overload is a common risk
Publikováno v:
Blood. 140:2465-2466
Autor:
Rei Matsumoto, Yun Zhu, Emily M. Mace, Michael Chait, Wen-Hsuan W. Lin, Eldad A. Hod, Didier Decimo, Branka Horvat, Matthew R. Baldwin, Steven B. Wells, Stephen A. Ferrara, Stuart P. Weisberg, Julia Davis-Porada, Pranay Dogra, Donna L. Farber, Debora Stelitano, Emma Idzikowski, Flavia Dei Zotti, Cyrille Mathieu, Francesca T. Bovier, Matteo Porotto, Zachary C. Bitan, Sandeep N. Wontakal, Francesca La Carpia, Anne Moscona, Krystalyn E. Hudson, Joshua I. Gray, Thomas J. Connors, Peter A. Szabo, Joshua D. Milner, Maya Meimei Li Poon
Publikováno v:
Nature Immunology
Nature Immunology, Nature Publishing Group, 2020, pp.25-31. ⟨10.1038/s41590-020-00826-9⟩
Nature Immunology, 2020, pp.25-31. ⟨10.1038/s41590-020-00826-9⟩
Nat Immunol
Nature Immunology, Nature Publishing Group, 2020, pp.25-31. ⟨10.1038/s41590-020-00826-9⟩
Nature Immunology, 2020, pp.25-31. ⟨10.1038/s41590-020-00826-9⟩
Nat Immunol
International audience; Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age1,2. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe
Autor:
Chaitanya R. Divgi, Tiffany Thomas, Debra Kessler, Travis Nemkov, Andrew Eisenberger, Angelo D'Alessandro, Yelena Ginzburg, Joseph E. Schwartz, Beth H. Shaz, Mark Soffing, Francesca Rapido, Julie A. Reisz, Steven L. Spitalnik, Eldad A. Hod, Sarah Gehrke, Arif Sheikh, Francesca La Carpia, Richard O. Francis, James C. Zimring, Esther Coronel, Randy Yeh
Publikováno v:
J Clin Invest
BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency decreases the ability of red blood cells (RBCs) to withstand oxidative stress. Refrigerated storage of RBCs induces oxidative stress. We hypothesized that G6PD-deficient donor RBCs would
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Loss of humoral tolerance to red blood cells (RBCs) can lead to autoimmune hemolytic anemia (AIHA), a severe, and sometimes fatal disease. Patients with AIHA present with pallor, fatigue, decreased hematocrit, and splenomegaly. While secondary AIHA i
Autor:
Elizabeth A. Godbey, Sheila Bandyopadhyay, Eldad A. Hod, Kevin A Prestia, Kevin P. Francis, Andrea R Slate, Francesca La Carpia, Boguslaw S. Wojczyk
Publikováno v:
Br J Haematol
Transfusion of storage-damaged red blood cells (RBCs) increases non-transferrin-bound iron (NTBI) levels in humans. This can potentially enhance virulence of microorganisms. In this study, Pseudomonas aeruginosa replication and biofilm production in