Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Francesca Iommelli"'
Autor:
Caterina De Rosa, Viviana De Rosa, Concetta Tuccillo, Virginia Tirino, Luisa Amato, Federica Papaccio, Davide Ciardiello, Stefania Napolitano, Giulia Martini, Fortunato Ciardiello, Floriana Morgillo, Francesca Iommelli, Carminia Maria Della Corte
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Osimertinib is a third-generation tyrosine kinase inhibitor clinically approved for first-line treatment of EGFR-mutant non-small cell lung cancer (NSCLC) patients. Although an impressive drug response is initially observed, in most of tumor
Externí odkaz:
https://doaj.org/article/7d656ea1f95540b390fad3f80f70a223
Autor:
Cristina Terlizzi, Viviana De Rosa, Francesca Iommelli, Antonio Pezone, Giovanna G. Altobelli, Maurizio Maddalena, Jelena Dimitrov, Caterina De Rosa, Carminia Maria Della Corte, Vittorio Enrico Avvedimento, Silvana Del Vecchio
Publikováno v:
Cancer & Metabolism, Vol 11, Iss 1, Pp 1-11 (2023)
Abstract Background ATM is a multifunctional serine/threonine kinase that in addition to its well-established role in DNA repair mechanisms is involved in a number of signaling pathways including regulation of oxidative stress response and metabolic
Externí odkaz:
https://doaj.org/article/e83d3991835d4c898a45587c3d859097
Autor:
Hamid Heydari Sheikhhossein, Francesca Iommelli, Natalia Di Pietro, Maria Cristina Curia, Adriano Piattelli, Rosanna Palumbo, Giovanni N. Roviello, Viviana De Rosa
Publikováno v:
Vaccines, Vol 12, Iss 5, p 519 (2024)
Cancer remains one of the main causes of death in the world due to its increasing incidence and treatment difficulties. Although significant progress has been made in this field, innovative approaches are needed to reduce tumor incidence, progression
Externí odkaz:
https://doaj.org/article/2a7525af2fbc4e9495b2bbc3753537d4
Autor:
Caterina De Rosa, Francesca Iommelli, Viviana De Rosa, Giuseppe Ercolano, Federica Sodano, Concetta Tuccillo, Luisa Amato, Virginia Tirino, Annalisa Ariano, Flora Cimmino, Gaetano di Guida, Gennaro Filosa, Alessandra di Liello, Davide Ciardiello, Erika Martinelli, Teresa Troiani, Stefania Napolitano, Giulia Martini, Fortunato Ciardiello, Federica Papaccio, Floriana Morgillo, Carminia Maria Della Corte
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 809 (2024)
Background: Lung cancer (LC), including both non-small (NSCLC) and small (SCLC) subtypes, is currently treated with a combination of chemo- and immunotherapy. However, predictive biomarkers to identify high-risk patients are needed. Here, we explore
Externí odkaz:
https://doaj.org/article/1b66bc9fe5414c49811d29401c6e567b
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 2, Iss 1, Pp 36-47 (2021)
The occurrence of phenotype switch from an epithelial to a mesenchymal cell state during the activation of the epithelial mesenchymal transition (EMT) program in cancer cells has been closely associated with the generation of invasive tumor cells tha
Externí odkaz:
https://doaj.org/article/ab3bf58d6b614ec6979258a052eafc00
Autor:
Viviana De Rosa, Francesca Iommelli, Cristina Terlizzi, Eleonora Leggiero, Rosa Camerlingo, Giovanna G. Altobelli, Rosa Fonti, Lucio Pastore, Silvana Del Vecchio
Publikováno v:
Cancers, Vol 13, Iss 16, p 4133 (2021)
Here, we tested whether co-targeting of glucose metabolism and oncogene drivers may enhance tumor response to tyrosine kinase inhibitors (TKIs) in NSCLC. To this end, pyruvate dehydrogenase kinase 1 (PDK1) was stably downregulated in oncogene-driven
Externí odkaz:
https://doaj.org/article/85e652cf7ed944f4b19db15cad4889e7
Autor:
Francesca Iommelli, Viviana De Rosa, Cristina Terlizzi, Rosa Fonti, Rosa Camerlingo, Maria Patrizia Stoppelli, C. Allison Stewart, Lauren Averett Byers, David Piwnica-Worms, Silvana Del Vecchio
Publikováno v:
Cancers, Vol 13, Iss 9, p 2022 (2021)
Notch1 plays a key role in epithelial-mesenchymal transition (EMT) and in the maintenance of cancer stem cells. In the present study we tested whether high levels of activated Notch1 in oncogene-driven NSCLC can induce a reversible shift of driver de
Externí odkaz:
https://doaj.org/article/d699f348411d4119a93d9529f216e920
Autor:
Stefania Belli, Paola Franco, Francesca Iommelli, Anna De Vincenzo, Diego Brancaccio, Marialucia Telesca, Francesco Merlino, Ettore Novellino, Marie Ranson, Silvana Del Vecchio, Paolo Grieco, Alfonso Carotenuto, Maria Patrizia Stoppelli
Publikováno v:
Cancers, Vol 12, Iss 9, p 2404 (2020)
Among peritumoral cells, cancer-associated fibroblasts (CAFs) are major facilitators of tumor progression. This study describes the effects of two urokinase-derived, novel decapeptides, denoted as Pep 1 and its cyclic derivative Pep 2. In a mouse mod
Externí odkaz:
https://doaj.org/article/3643a7e5821e4561ab6d9d1c0dc951ac
Autor:
Marcello Monti, Francesca Iommelli, Viviana De Rosa, Maria Vincenza Carriero, Roberta Miceli, Rosa Camerlingo, Giovanni Di Minno, Silvana Del Vecchio
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171362 (2017)
Neutrophil extracellular traps (NETs), originally recognized as a host defense mechanism, were reported to promote thrombosis and metastatic dissemination of cancer cells. Here we tested the role of integrins α5β1 and ανβ3 in the adhesion of can
Externí odkaz:
https://doaj.org/article/944a5bb624384373a76bf31c39b94e50
Autor:
Viviana De Rosa, Marcello Monti, Cristina Terlizzi, Rosa Fonti, Silvana Del Vecchio, Francesca Iommelli
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3134 (2019)
Since many oncogenes, including BCR-ABL, may promote the acquisition and maintenance of the glycolytic phenotype, we tested whether treatment of BCR-ABL-driven human leukemia cells with imatinib, a selective BCR-ABL inhibitor, can modulate the expres
Externí odkaz:
https://doaj.org/article/f5d676cd7dcb4fc983604549825f5f8b