Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase

Autor: Antoine Gedeon, Emilie Yab, Aurelia Dinut, Elodie Sadowski, Estelle Capton, Aurore Dreneau, Julienne Petit, Bruna Gioia, Catherine Piveteau, Kamel Djaout, Estelle Lecat, Anne Marie Wehenkel, Francesca Gubellini, Ariel Mechaly, Pedro M. Alzari, Benoît Deprez, Alain Baulard, Alexandra Aubry, Nicolas Willand, Stéphanie Petrella

Publikováno v: iScience, Vol 27, Iss 10, Pp 110967- (2024)

Summary: Antimicrobial resistance remains a persistent and pressing public health concern. Here, we describe the synthesis of original triazole-containing inhibitors targeting the DNA gyrase, a well-validated drug target for developing new antibiotic

Externí odkaz: https://doaj.org/article/f2ede360f26a40f4bc420e0ea048c2c6

Characterization of TelE, a T7SS LXG Effector Exhibiting a Conserved C-Terminal Glycine Zipper Motif Required for Toxicity

Autor: Wooi Keong Teh, Yichen Ding, Francesca Gubellini, Alain Filloux, Claire Poyart, Michael Givskov, Shaynoor Dramsi

Publikováno v: Microbiology Spectrum, Vol 11, Iss 4 (2023)

ABSTRACT Streptococcus gallolyticus subsp. gallolyticus (SGG) is an opportunistic bacterial pathogen strongly associated with colorectal cancer. Here, through comparative genomics analysis, we demonstrated that the genetic locus encoding the type VII

Externí odkaz: https://doaj.org/article/ecc2592d03a74047a7c1fd25df3a51e7

High resolution cryo-EM and crystallographic snapshots of the large actinobacterial 2-oxoglutarate dehydrogenase: an all-in-one fusion with unique properties

Autor: Lu Yang, Tristan Wagner, Ariel Mechaly, Alexandra Boyko, Eduardo M. Bruch, Daniela Megrian, Francesca Gubellini, Pedro M. Alzari, Marco Bellinzoni

Actinobacteria possess unique ways to regulate the oxoglutarate node located in the central position of the tricarboxylic acid cycle, a crossroad between energy conservation and nitrogen metabolism. Here, we studied the decarboxylative oxidation rout

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6db2bd2d5eecd8874789243ec849c110
https://doi.org/10.1101/2023.02.23.529587

Central role and structure of the membrane pseudokinase YukC in the antibacterial Bacillus subtilis Type VIIb Secretion System

Autor: Thierry Doan, Maïalène Chabalier, Matteo Tassinari, Pedro M. Alzari, Eric Cascales, Quentin Gaday, Rémi Fronzes, Marco Bellinzoni, Mathilde Ben-Assaya, Mariano Martinez, Francesca Gubellini

Posté dans BioRxiv le 9 mai 2020; We previously linked TSHZ3 haploinsufficiency to autism spectrum disorder (ASD) and showed that embryonic or postnatal Tshz3 deletion in mice results in behavioral traits relevant to the two core domains of ASD, nam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb27c08b0e0bfd4830bb25cc0c73d914
https://doi.org/10.1101/2020.05.09.085852

BAmSA: Visualising transmembrane regions in protein complexes using biotinylated amphipols and electron microscopy

Autor: Fabrice Giusti, Hager Souabni, Rémi Fronzes, Manuela Zoonens, Chiara Rapisarda, Jean-Luc Popot, Francesca Gubellini, Thomas Noe Perry

Publikováno v: Biochimica et Biophysica Acta:Biomembranes
Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2019, 1861 (2), pp.466-477. ⟨10.1016/j.bbamem.2018.11.004⟩
Biochimica et Biophysica Acta:Biomembranes, 2019, 1861 (2), pp.466-477. ⟨10.1016/j.bbamem.2018.11.004⟩

International audience; Membrane protein (MP) complexes play key roles in all living cells. Their structural characterisation is hampered by difficulties in purifying and crystallising them. Recent progress in electron microscopy (EM) have revolution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cec1b71efdcef4ea9b633dbf5c5cfa6
https://hal.archives-ouvertes.fr/hal-02329625