Polyvalent Transition-State Analogues of Sialyl Substrates Strongly Inhibit Bacterial Sialidases

Autor: Amélie Saumonneau, Coralie Assailly, Benoît Roubinet, Franck Daligault, Ludovic Landemarre, Francesca François, Cyrille Grandjean, Laurent Fontaine, Sagrario Pascual, paul lottin, Eva-Maria Krammer, frederica vena, Sébastien G. Gouin, David Deniaud, Véronique Montembault, Charles Tellier, Clarisse Bridot, Dimitri Alvarez-Dorta, Julie Bouckaert

Publikováno v: Chemistry – A European Journal
Chemistry-A European Journal
Chemistry-A European Journal, 2020, ⟨10.1002/chem.202004672⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2020, ⟨10.1002/chem.202004672⟩

Bacterial sialidases (SA) are validated drug targets expressed by common human pathogens such as Streptococcus pneumoniae, Vibrio cholerae, or Clostridium perfringens. Noncovalent inhibitors of bacterial SA capable of reaching the submicromolar level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e2ed2352152fdbb4d1ae65f567bc10

Poly(norbornenyl azlactone) as a versatile platform for sequential double click postpolymerization modification

Autor: Gwénaël Forcher, Laurent Fontaine, Francesca François, Clémence Nicolas, Véronique Montembault

Publikováno v: European Polymer Journal
European Polymer Journal, Elsevier, 2020, 141, pp.110081. ⟨10.1016/j.eurpolymj.2020.110081⟩

International audience; Ring-opening metathesis polymerization (ROMP) of a heterofunctional azlactone-based monomer, namely norbornenyl azlactone (NBAzl), is reported for the first time using third generation ruthenium-based catalyst (G3′). It is d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ee0c92f39fafd771e05f53bffb112d
https://doi.org/10.1016/j.eurpolymj.2020.110081