Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Francesca Ferrante"'
Autor:
Francesco Vladimiro Segala, Francesco Di Gennaro, Lucia A. A. Giannini, Giacomo Stroffolini, Agnese Colpani, Andrea De Vito, Stefano Di Gregorio, Luisa Frallonardo, Giacomo Guido, Roberta Novara, Angela Amendolara, Ilenia Annunziata Ritacco, Francesca Ferrante, Lorenzo Masini, Ilaria Iannetti, Salvatore Mazzeo, Silvia Marello, Nicola Veronese, Federico Gobbi, Roberta Iatta, Annalisa Saracino
Publikováno v:
Frontiers in Public Health, Vol 12 (2024)
BackgroundThe eco-climatic crisis has been defined by the World Health Organization as the “single biggest health threat facing humanity,” influencing both the emergence of zoonoses and the spread of vector-borne and water-borne diseases. The aim
Externí odkaz:
https://doaj.org/article/96da400497024e1282b8b38e3bd2035c
Autor:
Francesca Ferrante, Benedetto Daniele Giaimo, Tobias Friedrich, Toshiya Sugino, Daniel Mertens, Sabrina Kugler, Bernd Martin Gahr, Steffen Just, Leiling Pan, Marek Bartkuhn, Michael Potente, Franz Oswald, Tilman Borggrefe
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-9 (2022)
Abstract Notch signaling plays a pivotal role in the development and, when dysregulated, it contributes to tumorigenesis. The amplitude and duration of the Notch response depend on the posttranslational modifications (PTMs) of the activated NOTCH rec
Externí odkaz:
https://doaj.org/article/e94caf3b118449feae916a319b8e5115
Autor:
Małgorzata Sotomska, Robert Liefke, Francesca Ferrante, Heiko Schwederski, Franz Oswald, Tilman Borggrefe
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Background Notch signaling controls cell fate decisions in many contexts during development and adult stem cell homeostasis and, when dysregulated, leads to carcinogenesis. The central transcription factor RBPJ assembles the Notch coactivato
Externí odkaz:
https://doaj.org/article/6d3e69a6d2c64db095512c7cbf7fe9f2
Autor:
Rodrigo Diéguez-Hurtado, Katsuhiro Kato, Benedetto Daniele Giaimo, Melina Nieminen-Kelhä, Hendrik Arf, Francesca Ferrante, Marek Bartkuhn, Tobias Zimmermann, M. Gabriele Bixel, Hanna M. Eilken, Susanne Adams, Tilman Borggrefe, Peter Vajkoczy, Ralf H. Adams
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Pericytes are perivascular cells essential for blood-brain barrier maintenance. Here Diéguez-Hurtado et al. show that depletion of the transcription factor RBPJ in pericytes affects their molecular identity and disturbs endothelial cell behaviour, i
Externí odkaz:
https://doaj.org/article/7f0f3111c1374c77bebde1826c430b67
Autor:
Benedetto Daniele Giaimo, Francesca Ferrante, Andreas Herchenröther, Sandra B. Hake, Tilman Borggrefe
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-22 (2019)
Abstract The histone variant H2A.Z is involved in several processes such as transcriptional control, DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in diseases such as cancer. Here, we review the recent dev
Externí odkaz:
https://doaj.org/article/ed61ab6b1cc341758a41c4005dc851bd
Autor:
Derralynn A Hughes, Francesca Ferrante
Publikováno v:
Future Rare Diseases. 3
Gaucher disease type 1 (GD1), caused by mutations in the GBA1 gene, results in β-glucocerebrosidase (GCase) deficiency. Gene therapy is under investigation as a potential treatment option for patients with GD1. The investigational gene therapy FLT20
Autor:
Tobias Friedrich, Francesca Ferrante, Léo Pioger, Andrea Nist, Thorsten Stiewe, Jean-Christophe Andrau, Marek Bartkuhn, Benedetto Daniele Giaimo, Tilman Borggrefe
Publikováno v:
Nucleic acids research. 50(14)
Signal transduction pathways often involve transcription factors that promote activation of defined target gene sets. The transcription factor RBPJ is the central player in Notch signaling and either forms an activator complex with the Notch intracel
Autor:
Daniel Hall, Benedetto Daniele Giaimo, Sung-Soo Park, Wiebke Hemmer, Tobias Friedrich, Francesca Ferrante, Marek Bartkuhn, Zhenyu Yuan, Franz Oswald, Tilman Borggrefe, Jean-François Rual, Rhett A Kovall
The highly conserved Notch pathway transmits signals between neighboring cells to elicit distinct downstream transcriptional programs. In given contexts, Notch is a major regulator of cell fate specification, proliferation, and apoptosis, such that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ec58c1687d92450ea01df56726ab4d
https://doi.org/10.1101/2022.02.09.479311
https://doi.org/10.1101/2022.02.09.479311
Autor:
Tilman Borggrefe, Marek Bartkuhn, Thorsten Stiewe, Patricia Klöble, Daniel Mertens, Francesca Ferrante, Andrea Nist, Steffen Just, Viola Close, Johanna Meier-Soelch, Benedetto Daniele Giaimo, Franz Oswald, Michael Kracht, Tobias Zimmermann
Publikováno v:
Nucleic Acids Research
Aberrant Notch signaling plays a pivotal role in T-cell acute lymphoblastic leukemia (T-ALL) and chronic lymphocytic leukemia (CLL). Amplitude and duration of the Notch response is controlled by ubiquitin-dependent proteasomal degradation of the Notc
Autor:
Cassidy Guida, Garry Lachhar, Elnaz Mahbub, Anthony Modica, Francesca Ferrante, Andrew Melek, Saloni Sachar, Jorge Maldonado, Nishok Srinivasan, Heidi Roppelt, Ahsan Khan
Publikováno v:
American Journal of Gastroenterology. 117:e1319-e1319