Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Francesca Fang Liao"'
Autor:
Mahesh Chandra Kodali, Chinnu Salim, Saifudeen Ismael, Sarah Grace Lebovitz, Geng Lin, Francesca-Fang Liao
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-8 (2024)
Abstract The mechanisms through which systemic inflammation exerts its effect on the central nervous system (CNS) are still not completely understood. Exosomes are small (30 to 100 nm) membrane-bound extracellular vesicles released by most of the mam
Externí odkaz:
https://doaj.org/article/db7753accaa44e4ab1921896e587f609
Publikováno v:
Neurobiology of Disease, Vol 181, Iss , Pp 106096- (2023)
Striatal medium spiny neurons (MSNs) and striatal dopamine (DA) innervation are profoundly important for brain function such as motor control and cognition. A widely accepted theory posits that striatal DA loss causes (or leads to) MSN dendritic atro
Externí odkaz:
https://doaj.org/article/27c63f48dede4474963f0bc2b546522e
Autor:
Saifudeen Ismael, Sanaz Nasoohi, Lexiao Li, Khurram S. Aslam, Mohammad Moshahid Khan, Azza B. El-Remessy, Michael P. McDonald, Francesca-Fang Liao, Tauheed Ishrat
Publikováno v:
Neurobiology of Disease, Vol 156, Iss , Pp 105399- (2021)
Immune system hypersensitivity is believed to contribute to mental frailty in the elderly. Solid evidence indicates NOD-like receptor pyrin domain containing-3 (NLRP3)-inflammasome activation intimately connects aging-associated chronic inflammation
Externí odkaz:
https://doaj.org/article/62fc7f302ada4afc90c2d1aa3296b352
Autor:
Jing Jing Li, Bin Wang, Mahesh Chandra Kodali, Chao Chen, Eunhee Kim, Benjamin John Patters, Lubin Lan, Santosh Kumar, Xinjun Wang, Junming Yue, Francesca-Fang Liao
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-16 (2018)
Abstract Background Neuroinflammation is implicated in the development and progression of many neurodegenerative diseases. Conditions that lead to a peripheral immune response are often associated with inflammation in the central nervous system (CNS)
Externí odkaz:
https://doaj.org/article/59e6a617371a48f884301dbaf67427e4
Autor:
Hunter Franks, Ruishan Wang, Mingqi Li, Bin Wang, Ashton Wildmann, Tyler Ortyl, Shannon O'Brien, Deborah Young, Francesca‐Fang Liao, Kazuko Sakata
Publikováno v:
Journal of Neurochemistry. 165:131-148
Heat shock factor 1 (HSF1) is a master stress-responsive transcriptional factor, protecting cells from death. However, its gene regulation in vivo in the brain in response to neuronal stimuli remains elusive. Here, we investigated its direct regulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dcbfbf3dbd3e8628a8667008eba2ec4
https://doi.org/10.1111/jnc.15707
https://doi.org/10.1111/jnc.15707
Autor:
Ling Chen, Rajendra Raghow, Xing-Lin Tan, Geng Lin, Fu-Ming Zhou, Xingyong Chen, Andy Y. Shih, Francesca-Fang Liao, Wei Zheng
Publikováno v:
The American Journal of Pathology. 191:1932-1945
Age-related cerebral small-vessel disease (CSVD) is a major cause of stroke and dementia. Despite a widespread acceptance of small-vessel arteriopathy, lacunar infarction, diffuse white matter injury, and cognitive impairment as four cardinal feature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d889b450dce7a0e36071d48b1ced0271
https://doi.org/10.1016/j.ajpath.2021.02.022
https://doi.org/10.1016/j.ajpath.2021.02.022
Publikováno v:
PLoS Genetics, Vol 13, Iss 7, p e1006849 (2017)
The unfolded protein response (UPR) in the endoplasmic reticulum (ER) and the cytoplasmic heat stress response are two major stress response systems necessary for maintaining proteostasis for cellular health. Failure of either of these systems, such
Externí odkaz:
https://doaj.org/article/33041597a9444fdd9e4625e793409cc2
Autor:
Mingqi Li, Ling Li, Sarah Asemota, David Kakhniashvili, Ramesh Narayanan, Xusheng Wang, Francesca-Fang Liao
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Targeting nuclear factor-kappa B (NF-κB) represents a highly viable strategy against chemoresistance in cancers as well as cell death. Ubiquitination, including linear ubiquitination mediated by the linear ubiquitin chain assembly complex (LUBAC), i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6134ef09fad1f8f430d8715eadd88fab
https://doi.org/10.1073/pnas.2123097119
https://doi.org/10.1073/pnas.2123097119
Publikováno v:
Molecular Psychiatry
Sepsis-associated encephalopathy (SAE) is an acutely progressing brain dysfunction induced by systemic inflammation. The mechanism of initiation of neuroinflammation during SAE, which ultimately leads to delirium and cognitive dysfunction, remains el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d8b1fb201e0f212989b0b86c87632e
https://doi.org/10.1038/s41380-020-00955-5
https://doi.org/10.1038/s41380-020-00955-5
Autor:
Heba A. Ahmed, Saifudeen Ismael, Mohd. Salman, Patrick Devlin, Michael P. McDonald, Francesca-Fang Liao, Tauheed Ishrat
Publikováno v:
Molecular neurobiology. 59(7)
Alzheimer's disease (AD), currently the single leading cause of death still on the rise, almost always coexists alongside vascular cognitive impairment (VCI). In fact, the ischemic disease affects up to 90% of AD patients, with strokes and major infa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2e3e8eb0f15b9b88a94c12fb83d861
https://pubmed.ncbi.nlm.nih.gov/35486224
https://pubmed.ncbi.nlm.nih.gov/35486224