Výsledky vyhledávání - "Francesca Diella"

Akademický článek

Whole patient knowledge modeling of COVID-19 symptomatology reveals common molecular mechanisms

Autor: Stephan Brock, David B. Jackson, Theodoros G. Soldatos, Klaus Hornischer, Anne Schäfer, Francesca Diella, Maximilian Y. Emmert, Simon P. Hoerstrup

Publikováno v: Frontiers in Molecular Medicine, Vol 2 (2023)

Infection with SARS-CoV-2 coronavirus causes systemic, multi-faceted COVID-19 disease. However, knowledge connecting its intricate clinical manifestations with molecular mechanisms remains fragmented. Deciphering the molecular basis of COVID-19 at th

Externí odkaz: https://doaj.org/article/f661236c5ac44f2fbe68295fac4e48dc

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Akademický článek

The COVID-19 explorer—An integrated, whole patient knowledge model of COVID-19 disease

Autor: Stephan Brock, Theodoros G. Soldatos, David B. Jackson, Francesca Diella, Klaus Hornischer, Anne Schäfer, Simon P. Hoerstrup, Maximilian Y. Emmert

Publikováno v: Frontiers in Molecular Medicine, Vol 2 (2022)

Since early 2020 the COVID-19 pandemic has paralyzed the world, resulting in more than half a billion infections and over 6 million deaths within a 28-month period. Knowledge about the disease remains largely disjointed, especially when considering t

Externí odkaz: https://doaj.org/article/0c7caf67933440e19f1e44565f1c49c5

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Akademický článek

Deciphering a global network of functionally associated post‐translational modifications

Autor: Pablo Minguez, Luca Parca, Francesca Diella, Daniel R Mende, Runjun Kumar, Manuela Helmer‐Citterich, Anne‐Claude Gavin, Vera van Noort, Peer Bork

Publikováno v: Molecular Systems Biology, Vol 8, Iss 1, Pp 1-14 (2012)

Abstract Various post‐translational modifications (PTMs) fine‐tune the functions of almost all eukaryotic proteins, and co‐regulation of different types of PTMs has been shown within and between a number of proteins. Aiming at a more global vie

Externí odkaz: https://doaj.org/article/f6ed9ad756794614ad2f4a25f923a13e

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Akademický článek

Evidence for the concerted evolution between short linear protein motifs and their flanking regions.

Autor: Claudia Chica, Francesca Diella, Toby J Gibson

Publikováno v: PLoS ONE, Vol 4, Iss 7, p e6052 (2009)

BACKGROUND: Linear motifs are short modules of protein sequences that play a crucial role in mediating and regulating many protein-protein interactions. The function of linear motifs strongly depends on the context, e.g. functional instances mainly o

Externí odkaz: https://doaj.org/article/a75f10dac93e478d836af0efdb00365b

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How to Annotate and Submit a Short Linear Motif to the Eukaryotic Linear Motif Resource

Autor: Marc, Gouw, Jesús, Alvarado-Valverde, Jelena, Čalyševa, Francesca, Diella, Manjeet, Kumar, Sushama, Michael, Kim, Van Roey, Holger, Dinkel, Toby J, Gibson

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2141

Over the past few years, it has become apparent that approximately 35% of the human proteome consists of intrinsically disordered regions. Many of these disordered regions are rich in short linear motifs (SLiMs) which mediate protein-protein interact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::36531204f473b6e39413d4c66741fbb4
https://pubmed.ncbi.nlm.nih.gov/32696353

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How to Annotate and Submit a Short Linear Motif to the Eukaryotic Linear Motif Resource

Autor: Kim Van Roey, Jesús Alvarado-Valverde, Manjeet Kumar, Marc Gouw, Francesca Diella, Sushama Michael, Jelena Čalyševa, Holger Dinkel, Toby J. Gibson

Publikováno v: Intrinsically Disordered Proteins: Methods and Protocols
Methods in Molecular Biology
Methods in Molecular Biology-Intrinsically Disordered Proteins
Intrinsically Disordered Proteins-Methods and Protocols
Methods in Molecular Biology ISBN: 9781071605233

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d095e243ef4b9689ee51a2c04e603ded
https://hdl.handle.net/21.11116/0000-0006-C2E3-E

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Public Adverse Event Data Insights into the Safety of Pembrolizumab in Melanoma Patients

Autor: Christos Sachpekidis, Theodoros G. Soldatos, Christian T. Meisel, Anja Doerks, Anne-Sophie Kratz, Francesca Diella, Anne Schaefer, David B. Jackson

Publikováno v: Schaefer, Anne; Sachpekidis, Christos; Diella, Francesca; Doerks, Anja; Kratz, Anne-Sophie; Meisel, Christian; Jackson, David B; Soldatos, Theodoros G (2020). Public Adverse Event Data Insights into the Safety of Pembrolizumab in Melanoma Patients. Cancers, 12(4) MDPI AG 10.3390/cancers12041008
Cancers
Volume 12
Issue 4
Cancers, Vol 12, Iss 1008, p 1008 (2020)

Immune checkpoint inhibition represents an important therapeutic option for advanced melanoma patients. Results from clinical studies have shown that treatment with the PD-1 inhibitors Pembrolizumab and Nivolumab provides improved response and surviv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f6f59e8032c1da54be9f192f039f13

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The eukaryotic linear motif resource: 2018 update

Publikováno v: Nucleic Acids Research (London)
Nucleic Acids Research
Nucleic acids research, 46(D1):D428-D434
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Short linear motifs (SLiMs) are protein binding modules that play major roles in almost all cellular processes. SLiMs are short, often highly degenerate, difficult to characterize and hard to detect. The eukaryotic linear motif (ELM) resource (elm.eu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe65277846e97b743cd80a6d8b55f14
https://hdl.handle.net/21.11116/0000-0004-72B8-C

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