Výsledky vyhledávání - "Francesca Crasto"

Sensitive Replicate Real-Time Quantitative PCR of BCR-ABL Shows Deep Molecular Responses in Long-Term Post–Allogeneic Stem Cell Transplantation Chronic Myeloid Leukemia Patients

Autor: Filomena Daraio, Francesca Crasto, Yulia Volchek, Arnon Nagler, Ninette Amariglio, Roberta Lorenzatti, Giuseppe Saglio, Maya Koren-Michowitz, Enrico Gottardi, Avichai Shimoni

Publikováno v: Biology of Blood and Marrow Transplantation. 21:1852-1855

Real-time quantitative PCR (RT-qPCR) is commonly used for follow-up of chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors, but its current sensitivity does not allow detection of very low BCR-ABL levels. Therefore RT-qPCR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225a878eda29f70486b86d98b663c3ed
https://doi.org/10.1016/j.bbmt.2015.06.018

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Non genomic loss of function of tumor suppressors in CML: BCR-ABL promotes IκBα mediated p53 nuclear exclusion

Autor: Francesca Crasto, Enrico Gottardi, Giuseppe Saglio, Alessandro Morotti, Sabrina Crivellaro, Riccardo Taulli, Ubaldo Familiari, Rocco Piazza, Mauro Papotti, Giovanna Carrà, Sara Redaelli, Angelo Guerrasio, Cristina Panuzzo, Davide Torti, Alessandro Volpengo

Publikováno v: Oncotarget

Tumor suppressor function can be modulated by subtle variation of expression levels, proper cellular compartmentalization and post-translational modifications, such as phosphorylation, acetylation and sumoylation. The non-genomic loss of function of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::befa789e57efb9a76bde92c9fd7f3d2a
https://doi.org/10.18632/oncotarget.4611

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Clinical significance ofTFR2andEPORexpression in bone marrow cells in myelodysplastic syndromes

Autor: Augusta Di Savino Valentina Gaidano Antonietta Palmieri Francesca Crasto Alessandro Volpengo Roberta Lorenzatti Patrizia Scaravaglio Alessandro Manello Paolo Nicoli Enrico Gottardi Giuseppe Saglio Daniela Cilloni Marco De Gobbi

Publikováno v: British journal of haematology
176 (2017): 491–495.
info:cnr-pdr/source/autori:Augusta Di Savino Valentina Gaidano Antonietta Palmieri Francesca Crasto Alessandro Volpengo Roberta Lorenzatti Patrizia Scaravaglio Alessandro Manello Paolo Nicoli Enrico Gottardi Giuseppe Saglio Daniela Cilloni Marco De Gobbi/titolo:Clinical significance ofTFR2andEPORexpression in bone marrow cells in myelodysplastic syndromes/doi:/rivista:British journal of haematology (Print)/anno:2017/pagina_da:491/pagina_a:495/intervallo_pagine:491–495/volume:176

The experiments were conceived, designed and performed by Augusta Di Savino, Antonietta Palmieri, Marco De Gobbi. RNA extraction from patients' bone marrow samples was performed by Alessandro Volpengo, Francesca Crasto, Roberta Lorenzatti and Enrico

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::1860e89601c18b2a774b96c741048a0b
http://www.cnr.it/prodotto/i/368982

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Early BCR-ABL1 Reduction Is Predictive of Better Event-free Survival in Patients With Newly Diagnosed Chronic Myeloid Leukemia Treated With Any Tyrosine Kinase Inhibitor

Autor: Enrico Gottardi, Carmen Fava, Paola Berchialla, Alessandro Volpengo, Filomena Daraio, Irene Dogliotti, Francesca Crasto, Giovanna Rege-Cambrin, Bruno Di Gioacchino, Roberta Lorenzatti, Cristina Fantino, Giuseppe Saglio

Publikováno v: Clinical lymphoma, myelomaleukemia.

An early molecular response has a strong predictive value in chronic myeloid leukemia (CML). Recently, the halving time (velocity of early BCR-ABL1 transcript elimination) has been shown to represent an additional prognostic index. Our objective was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb005c13aec35328c8e83748158d149
https://pubmed.ncbi.nlm.nih.gov/27131622

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Evaluation of Cepheid Xpert® BCR-ABL Monitor Assay in Three Italian Reference Centers for Monitoring of BCR-ABL Transcript Levels in CML Patients

Autor: Roberta Lorenzatti, Maria Teresa Bochicchio, Filomena Daraio, Caterina De Benedittis, Enrico Gottardi, Emanuela Ottaviani, Francesca Crasto, Giuseppe Saglio, Barbara Izzo, Alessandro Volpengo, Claudia Venturi, Biagio De Angelis, Fabrizio Pane, Giovanni Martinelli

Publikováno v: Blood. 124:1809-1809

Effective management of tyrosine kinase inhibitor (TKI) therapy for patients with CML requires frequent patient testing to monitor patient disease status. The gold standard for this testing is a PCR measurement of the BCR-ABL/ABL transcript ratio. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a562740c76db521fa1a02b4fa28f43
https://doi.org/10.1182/blood.v124.21.1809.1809

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Consistency Of RQ-PCR Analysis Results In Peripheral Blood and Bone Marrow Samples In Chronic Myeloid Leukemia Patients: Relevance From The Practical and Logistic Point Of View

Autor: Giovanna Rege-Cambrin, Carmen Fava, Enrico Gottardi, Filomena Daraio, Emilia Giugliano, Francesca Crasto, Roberta Lorenzatti, Alessandro Volpengo, Bruno Di Gioacchino, Giuseppe Saglio

Publikováno v: Blood. 122:2592-2592

Background Consensus has been achieved that standardized molecular quantitative analysis (RQ-PCR) on peripheral blood (PB) is a suitable method for monitoring residual disease in chronic myeloid leukemia (CML). However, BM is still obtained at specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54809d80c5bcc16a23de7e66065160ec
https://doi.org/10.1182/blood.v122.21.2592.2592

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One Step Quantitative Molecular Approach for Detection of BCR/ABL Translocation and for Monitoring and Follow up of the Minimal Residual Disease in CML Patients Under Tyrosine Kines Inhibitors Treatment

Autor: Rosy Volpi, Filomena Daraio, Giuseppe Saglio, Enrico Gottardi, Giovanna Rege-Cambrin, Cristina Olivo, Matteo Renzulli, Roberta Lorenzatti, Carmen Fava, Francesca Crasto, Davide Barberis

Publikováno v: Blood. 120:4435-4435

Abstract 4435 In patients with chronic myeloid leukemia (CML) a correct and careful monitoring of the response to treatment with tyrosine kinase inhibitors (TKI) is essential in order to properly manage the disease. The use of standardised rapid and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafbd1b6ceed58258bc3c112e37f7b6c
https://doi.org/10.1182/blood.v120.21.4435.4435

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